Page last updated: 2024-12-06

glycosine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

glycosine: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	63123
CHEMBL ID	448122
CHEBI ID	2803
SCHEMBL ID	1150473
MeSH ID	M0062230

Synonyms (34)

Synonym
glycosin
nsc127745
nsc-127745
arborin
4(1h)-quinazolinone, 1-methyl-2-(phenylmethyl)-
4(1h)-quinazolinone, 2-benzyl-1-methyl-
mls002919960 ,
6873-15-0
glycosine
arborine
smr001797559
2-benzyl-1-methylquinazolin-4-one
chebi:2803 ,
CHEMBL448122
unii-d5juh3hnwf
nsc 127745
1-methyl-2-(phenylmethyl)-4(1h)-quinazolinone
d5juh3hnwf ,
glycosine [mi]
2-benzyl-1-methylquinazol-4-one
2-benzyl-1-methylquinazolin-4(1h)-one
SCHEMBL1150473
DTXSID10218856
AKOS024258266
2-benzyl-1-methyl-1,4-dihydroquinazolin-4-one
2-benzyl-1-methyl-4(1h)-quinazolinone
4(1h)-quinazolinone, 2-benzyl-1-methyl- (8ci)
4(1h)-quinazolinone, 1-methyl-2-(phenylmethyl)- (9ci)
1-methyl-2-(phenylmethyl)quinazolin-4-one
Q27105821
CS-0101513
HY-N7004
MS-23544
A866991

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
quinazolines	Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (17)

Assay ID	Title	Year	Journal	Article
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID333232	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 16 nM after 48 hrs relative to control	2004	Journal of natural products, Sep, Volume: 67, Issue:9	Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
AID333235	Cytotoxicity against human Raji cells at 3.2 nM after 48 hrs by trypan blue staining method	2004	Journal of natural products, Sep, Volume: 67, Issue:9	Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
AID333230	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 32 nM after 48 hrs relative to control	2004	Journal of natural products, Sep, Volume: 67, Issue:9	Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
AID333234	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 3.2 nM after 48 hrs relative to control	2004	Journal of natural products, Sep, Volume: 67, Issue:9	Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
AID333231	Cytotoxicity against human Raji cells at 32 nM after 48 hrs by trypan blue staining method	2004	Journal of natural products, Sep, Volume: 67, Issue:9	Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
AID333236	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 0.32 nM after 48 hrs relative to control	2004	Journal of natural products, Sep, Volume: 67, Issue:9	Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
AID333237	Cytotoxicity against human Raji cells at 0.32 nM after 48 hrs by trypan blue staining method	2004	Journal of natural products, Sep, Volume: 67, Issue:9	Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
AID333233	Cytotoxicity against human Raji cells at 16 nM after 48 hrs by trypan blue staining method	2004	Journal of natural products, Sep, Volume: 67, Issue:9	Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (27.27)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (36.36)	29.6817
2010's	3 (27.27)	24.3611
2020's	1 (9.09)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 47.58

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	47.58 (24.57)
Research Supply Index	2.48 (2.92)
Research Growth Index	4.02 (4.65)
Search Engine Demand Index	72.10 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (47.58)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
gallic acid gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.	2.05	1	trihydroxybenzoic acid	antineoplastic agent; antioxidant; apoptosis inducer; astringent; cyclooxygenase 2 inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; geroprotector; human xenobiotic metabolite; plant metabolite
skimmianine skimmianine: furanoquinoline alkaloid from Teclea (RUTACEAE)	2.25	1	alkaloid antibiotic; organic heterotricyclic compound; organonitrogen heterocyclic compound; oxacycle
quinazolines Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.	2.43	2	azaarene; mancude organic heterobicyclic parent; ortho-fused heteroarene; quinazolines
gamma-fagarine gamma-fagarine: active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae); structure given in first source	2.02	1	organic heterotricyclic compound; organonitrogen heterocyclic compound; oxacycle
deoxycholic acid Deoxycholic Acid: A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.. deoxycholic acid : A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.	2.02	1	bile acid; C24-steroid; dihydroxy-5beta-cholanic acid	human blood serum metabolite
beta carotene beta Carotene: A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC).. provitamin A : A provitamin that can be converted into vitamin A by enzymes from animal tissues.	2.02	1	carotenoid beta-end derivative; cyclic carotene	antioxidant; biological pigment; cofactor; ferroptosis inhibitor; human metabolite; mouse metabolite; plant metabolite; provitamin A
arborinine arborinine: structure	2.02	1	acridines
beta-escin [no description available]	2.05	1

Condition	Indicated	Relationship Strength	Studies	Trials
Innate Inflammatory Response [description not available]	0	2.05	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	0	2.05	1	0

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