Compounds > 7-goniofufurone
Page last updated: 2024-11-07

7-goniofufurone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

7-goniofufurone: from Goniothalamus giganteus; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID126236
MeSH IDM0197715
PubMed CID11096987
CHEMBL ID1171386
MeSH IDM0197715

Synonyms (10)

Synonym
7-goniofufurone
(2r,3s,3ar,6ar)-3-hydroxy-2-[hydroxy(phenyl)methyl]-3,3a,6,6a-tetrahydro-2h-furo[3,2-b]furan-5-one
ido-heptonic acid, 3,6-anhydro-2-deoxy-7-c-phenyl-, gamma-lactone, stereoisomer
3,6-anhydro-2-deoxy-7-c-phenylido-heptonic acid gamma-lactone, stereoisomer
136778-39-7
(+)-goniofufurone
CHEMBL1171386
goniofufurone
129578-06-9
DTXSID301317805
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (126)

Assay IDTitleYearJournalArticle
AID1438256Induction of apoptosis in human K562 cells assessed as active caspase3 expression level at antiproliferative IC50 after 72 hrs by western blot analysis relative to control2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1571432Cell cycle arrest in human K562 cells assessed as accumulation at sub-G1 phase at IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 1.84%)
AID1438270Induction of apoptosis in human K562 cells assessed as gated cells at early apoptotic stage at antiproliferative IC50 after 72 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry relative to control (Rvb = 0.46 to 0.67%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1491009Antiproliferative activity against human NCI/ADR-RES cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1490967Antiproliferative activity against human CCRF-CEM cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438252Induction of apoptosis in human K562 cells assessed as necrotic cells at antiproliferative IC50 after 72 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry relative to control2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1490984Antiproliferative activity against human HCT116 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1491026Antiproliferative activity against human MDA-MB-468 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1490988Antiproliferative activity against human SW620 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1490969Antiproliferative activity against human K562 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438235Antiproliferative activity against human K562 cells after 72 hrs by MTT assay2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1571437Induction of apoptosis in human K562 cells assessed as apoptotic cells at IC50 after 72 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control
AID1490975Antiproliferative activity against human HOP62 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438268Induction of apoptosis in human K562 cells assessed as gated cells at late apoptotic stage at antiproliferative IC50 after 72 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry relative to control (Rvb = 1.7 to 2.41%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1438262Cell cycle arrest in human K562 cells assessed as gated cell levels at subG1 phase at antiproliferative IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 0.44 to 0.55%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1438249Cell cycle arrest in human K562 cells assessed as accumulation at G2/M phase at antiproliferative IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 15.14 to 21.28%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1490994Antiproliferative activity against human U251 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1571433Cell cycle arrest in human K562 cells assessed as accumulation at G0/G1 phase at IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 47.51%)
AID1490996Antiproliferative activity against human MALME-3M cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1571424Cytotoxicity against human Raji cells assessed as inhibition of cell growth after 72 hrs by MTT assay
AID1491021Antiproliferative activity against human MCF7 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438269Induction of apoptosis in human K562 cells assessed as gated cells at live stage at antiproliferative IC50 after 72 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry relative to control (Rvb = 94.01 to 96.04%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1490976Antiproliferative activity against human HOP92 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1571428Cytotoxicity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
AID1571445Up regulation of cleaved PARP expression in human K562 cells at IC50 measured after 72 hrs by Western blot analysis
AID773702Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
Heteroannelated and 7-deoxygenated goniofufurone mimics with antitumour activity: design, synthesis and preliminary SAR studies.
AID1491011Antiproliferative activity against human 786-0 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1491003Antiproliferative activity against human UACC62 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1491007Antiproliferative activity against human OVCAR5 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438258Induction of apoptosis in human K562 cells assessed as cleaved PARP expression level at antiproliferative IC50 after 72 hrs by western blot analysis relative to control2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1571422Cytotoxicity against human HL60 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
AID1490971Antiproliferative activity against human RPMI8226 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1491000Antiproliferative activity against human SK-MEL-28 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1571425Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
AID490014Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay2010European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
Design, synthesis and antiproliferative activity of styryl lactones related to (+)-goniofufurone.
AID1490978Antiproliferative activity against human NCI-H23 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438255Induction of apoptosis in human K562 cells assessed as procaspase3 expression level at antiproliferative IC50 after 72 hrs by western blot analysis relative to control2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1571434Cell cycle arrest in human K562 cells assessed as accumulation at S phase at IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 26.52%)
AID1438240Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1438263Cell cycle arrest in human K562 cells assessed as total cell population at G0/G1 phase at antiproliferative IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 39.97%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1438239Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1438272Induction of apoptosis in human K562 cells assessed as total cells at late apoptotic stage at antiproliferative IC50 after 72 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry relative to control (Rvb = 1.32 to 1.42%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1490992Antiproliferative activity against human SNB19 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID490017Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay2010European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
Design, synthesis and antiproliferative activity of styryl lactones related to (+)-goniofufurone.
AID1491024Antiproliferative activity against human BT549 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438253Induction of apoptosis in human K562 cells assessed as Bcl-2 protein expression level at antiproliferative IC50 after 72 hrs by western blot analysis relative to control2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1491020Antiproliferative activity against human DU145 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1491013Antiproliferative activity against human ACHN cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID490015Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay2010European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
Design, synthesis and antiproliferative activity of styryl lactones related to (+)-goniofufurone.
AID1491004Antiproliferative activity against human IGROV1 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1490980Antiproliferative activity against human NCI-H460 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438271Induction of apoptosis in human K562 cells assessed as total cells at necrotic stage at antiproliferative IC50 after 72 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry relative to control (Rvb = 1.4 to 1.5%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1571421Cytotoxicity against human K562 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
AID773705Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
Heteroannelated and 7-deoxygenated goniofufurone mimics with antitumour activity: design, synthesis and preliminary SAR studies.
AID1490990Antiproliferative activity against human SF295 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1490999Antiproliferative activity against human SK-MEL-2 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1571441Up regulation of Bax expression in human K562 cells at IC50 measured after 72 hrs by Western blot analysis
AID1438267Induction of apoptosis in human K562 cells assessed as gated cells at necrotic stage at antiproliferative IC50 after 72 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry relative to control (Rvb = 1.8 to 1.91%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1490989Antiproliferative activity against human SF268 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1491022Antiproliferative activity against human MDA-MB-231 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438261Cell cycle arrest in human K562 cells assessed as gated cell levels at G2/M phase at antiproliferative IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 15.84 to 21.28%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1571429Cytotoxicity against human MRC5 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
AID1490973Antiproliferative activity against human A549/ATCC cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1491014Antiproliferative activity against human Caki1 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438264Cell cycle arrest in human K562 cells assessed as total cell population at S phase at antiproliferative IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 36.49%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1571435Cell cycle arrest in human K562 cells assessed as accumulation at G2/M phase at IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 24.13%)
AID1490972Antiproliferative activity against human SR cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438242Antiproliferative activity against human MRC5 cells after 72 hrs by MTT assay2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID773703Antiproliferative activity against human MRC5 cells after 72 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
Heteroannelated and 7-deoxygenated goniofufurone mimics with antitumour activity: design, synthesis and preliminary SAR studies.
AID1490974Antiproliferative activity against human EKVX cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1490981Antiproliferative activity against human NCI-H522 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1490985Antiproliferative activity against human HCT15 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438265Cell cycle arrest in human K562 cells assessed as total cell population at G2/M phase at antiproliferative IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 14.31%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1490982Antiproliferative activity against human COLO205 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID773708Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
Heteroannelated and 7-deoxygenated goniofufurone mimics with antitumour activity: design, synthesis and preliminary SAR studies.
AID1438260Cell cycle arrest in human K562 cells assessed as gated cell levels at S phase at antiproliferative IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 22.92 to 40.37%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1491012Antiproliferative activity against human A498 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1491025Antiproliferative activity against human T47D cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1571427Cytotoxicity against human HeLa cells assessed as inhibition of cell growth after 72 hrs by MTT assay
AID1491006Antiproliferative activity against human OVCAR4 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID490016Antiproliferative activity against human Raji cells after 72 hrs by MTT assay2010European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
Design, synthesis and antiproliferative activity of styryl lactones related to (+)-goniofufurone.
AID490018Antiproliferative activity against human MRC5 cells after 72 hrs by MTT assay2010European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
Design, synthesis and antiproliferative activity of styryl lactones related to (+)-goniofufurone.
AID1491002Antiproliferative activity against human UACC257 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438274Induction of apoptosis in human K562 cells assessed as total cells at early apoptotic stage at antiproliferative IC50 after 72 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry relative to control (Rvb = 0.36 to 0.37%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1438246Cell cycle arrest in human K562 cells assessed as accumulation at sub-G1 phase at antiproliferative IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 0.44 to 0.55%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1438241Antiproliferative activity against human A549 cells after 72 hrs by MTT assay2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1438259Cell cycle arrest in human K562 cells assessed as gated cell levels at G0/G1 phase at antiproliferative IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 44.22 to 55.41%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1438248Cell cycle arrest in human K562 cells assessed as accumulation at S phase at antiproliferative IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 22.92 to 40.15%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1491017Antiproliferative activity against human TK10 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438273Induction of apoptosis in human K562 cells assessed as total cells at live stage at antiproliferative IC50 after 72 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry relative to control (Rvb = 74.74%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1571438Induction of apoptosis in human K562 cells assessed as necrotic cells at IC50 after 72 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control
AID1490987Antiproliferative activity against human KM12 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1490983Antiproliferative activity against human HCC2998 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1490986Antiproliferative activity against human HT-29 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1491018Antiproliferative activity against human UO31 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1491008Antiproliferative activity against human OVCAR8 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID773707Antiproliferative activity against human K562 cells after 72 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
Heteroannelated and 7-deoxygenated goniofufurone mimics with antitumour activity: design, synthesis and preliminary SAR studies.
AID1491005Antiproliferative activity against human OVCAR3 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1491015Antiproliferative activity against human RXF393 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1491019Antiproliferative activity against human PC3 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438254Induction of apoptosis in human K562 cells assessed as BAX protein expression level at antiproliferative IC50 after 72 hrs by western blot analysis relative to control2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1438247Cell cycle arrest in human K562 cells assessed as accumulation at G0/G1 phase at antiproliferative IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 44.16 to 55.41%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1490970Antiproliferative activity against human MOLT4 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1571439Up regulation of Bcl-2 expression in human K562 cells at IC50 measured after 72 hrs by Western blot analysis
AID1571423Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth after 72 hrs by MTT assay
AID773706Antiproliferative activity against human Raji cells after 72 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
Heteroannelated and 7-deoxygenated goniofufurone mimics with antitumour activity: design, synthesis and preliminary SAR studies.
AID1490997Antiproliferative activity against human M14 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438257Induction of apoptosis in human K562 cells assessed as precursor PARP expression level at antiproliferative IC50 after 72 hrs by western blot analysis relative to control2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1438237Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1491010Antiproliferative activity against human SKOV3 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438251Induction of apoptosis in human K562 cells at antiproliferative IC50 after 72 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry relative to control2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1490979Antiproliferative activity against human NCI-H322M cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1490991Antiproliferative activity against human SF539 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438266Cell cycle arrest in human K562 cells assessed as total cell population at subG1 phase at antiproliferative IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 0.5%)2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1571426Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
AID1438236Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1490993Antiproliferative activity against human SNB75 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1491023Antiproliferative activity against human Hs 578T cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1438238Antiproliferative activity against human Raji cells after 72 hrs by MTT assay2017European journal of medicinal chemistry, Mar-10, Volume: 128Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position.
AID1491001Antiproliferative activity against human SK-MEL-5 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1491016Antiproliferative activity against human SN12C cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1490995Antiproliferative activity against human LOXIMVI cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID490013Antiproliferative activity against human K562 cells after 72 hrs by MTT assay2010European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
Design, synthesis and antiproliferative activity of styryl lactones related to (+)-goniofufurone.
AID1490977Antiproliferative activity against human NCI-H226 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1490998Antiproliferative activity against human MDA-MB-435 cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
AID1490968Antiproliferative activity against human HL-60(TB) cells at 10 uM incubated for 48 hrs by sulforhodamine B assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
Total Synthesis, Configuration Assignment, and Cytotoxic Activity Evaluation of Protulactone A.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (5.88)18.2507
2000's6 (35.29)29.6817
2010's9 (52.94)24.3611
2020's1 (5.88)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Observational0 (0.00%)0.25%
Other16 (100.00%)84.16%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glycerol
Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.		2.0210alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		2.0310alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
ethaverine
ethaverine: tetraethyl homolog of papaverine; smooth muscle relaxant; RN given refers to parent cpd; structure		2.0410isoquinolines
papaverine
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.. papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.		2.0410benzylisoquinoline alkaloid;
dimethoxybenzene;
isoquinolines		antispasmodic drug;
vasodilator agent
mannitol
[no description available]		2.0310mannitolallergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent
4-butyrolactone
4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.		2.0210butan-4-olidemetabolite;
neurotoxin
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		2.0610pyrrole;
secondary amine
thiazoles
[no description available]		2.41101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
oxetane
oxetane: structure. oxetane : A saturated organic heteromonocyclic parent that is a four-membered ring comprising of three carbon atoms and an oxygen atom.		2.1310oxetanes;
saturated organic heteromonocyclic parent
silver
Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.		2.0610copper group element atom;
elemental silver		Escherichia coli metabolite
titanium
Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.		2.0810titanium group element atom
fluorides
[no description available]		2.0810halide anion;
monoatomic fluorine
azides
Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.		2.1510pseudohalide anionmitochondrial respiratory-chain inhibitor
titanium tetrafluoride
[no description available]		2.0810
xylose
xylopyranose: structure in first source		2.4420D-xylose
altholactone
altholactone: structure in first source		2.0410furopyran
muricatacin
muricatacin: structure given in first source		2.0310long-chain fatty alcohol
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.5520
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.5520