Page last updated: 2024-11-06

calconcarboxylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID77330
CHEMBL ID331220
SCHEMBL ID737568
SCHEMBL ID1229539
MeSH IDM0224634

Synonyms (56)

Synonym
2-naphthalenecarboxylic acid, 3-hydroxy-4-(2-(2-hydroxy-4-sulfo-1-naphthalenyl)diazenyl)-
unii-qy572zc8vg
nsc 97307
qy572zc8vg ,
einecs 223-117-0
2-naphthalenecarboxylic acid, 3-hydroxy-4-((2-hydroxy-4-sulfo-1-naphthalenyl)azo)-
SMP1_000051
patton and reeder's indicator
2-hydroxy-1-(2-hydroxy-4-sulfo-1-napthylazo)-3-naphthoic acid
2-naphthoic acid, 3-hydroxy-4-[(2-hydroxy-4-sulfo-1-naphthyl)azo]-
calcon 3-carboxylic acid
3737-95-9
nsc-97307
patton-reeder indicator
calconcarbonic acid
calconcarboxylic acid
nsc97307
2-naphthalenecarboxylic acid, 3-hydroxy-4-[(2-hydroxy-4-sulfo-1-naphthalenyl)azo]-
3-hydroxy-4-[(e)-(2-hydroxy-4-sulfo-1-naphthyl)azo]naphthalene-2-carboxylic acid
2,2'-dihydroxy-4'-sulpho-1,1'-azonaphthalene-3-carboxylic acid
2-hydroxy-1-(2-hydroxy-4-sulfo-1-naphthylazo)-3-naphthoic acid
CHEMBL331220 ,
bdbm50105956
3-hydroxy-4-(2-hydroxy-4-sulfo-naphthalen-1-ylazo)-naphthalene-2-carboxylic acid
cal red
calcon-carboxylic acid
H0250
FT-0612518
SCHEMBL737568
DTXSID5063156
SCHEMBL1229539
AKOS024285057
W-106543
3-hydroxy-4-(2-hydroxy-4-sulfo-1-naphthylazo)naphthalene-2-carboxylic acid
3-hydroxy-4-[(2-hydroxy-4-sulfo-1-naphthyl)diazenyl]-2-naphthoic acid #
MVQBFZXBLLMXGS-UHFFFAOYSA-N
2-naphthoic acid, 3-hydroxy-4-((2-hydroxy-4-sulfo-1-naphthyl)azo)-
3-hydroxy-4-(2-hydroxy-4-sulfo-1-naphthylazo)-2-naphthalenecarboxylic acid
2-hydroxy-1-(2-hydroxy-4-sulpho-1-naphthylazo)-3-naphthoic acid
mfcd00004078
nn, cp
calconcarbonsaure
2-naphthalenecarboxylic acid,3-hydroxy-4-[(2-hydroxy-4-sulfo-1-naphthalenyl)azo]-
Q570828
patton and reeder's reagent
3-hydroxy-4-[(2-hydroxy-4-sulfonaphthalen-1-yl)diazenyl]naphthalene-2-carboxylic acid
(e)-3-hydroxy-4-((2-hydroxy-4-sulfonaphthalen-1-yl)diazenyl)-2-naphthoic acid
3-hydroxy-4-((2-hydroxy-4-sulfonaphthalen-1-yl)diazenyl)-2-naphthoic acid
kalces; nn; nsc 97307; patton and reeder's indicator
H11925
2-naphthalenecarboxylic acid, 3-hydroxy-4-[2-(2-hydroxy-4-sulfo-1-naphthalenyl)diazenyl]-
3-hydroxy-4-[2-(2-hydroxy-4-sulfo-1-naphthalenyl)diazenyl]-2-naphthalenecarboxylic acid
kalces
calcon-3-carboxylic acid
cal-red
patton-reeders reagent (calconcarboxylic acid) indicator
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Thrombopoietin receptorHomo sapiens (human)EC50 (µMol)10.00000.03803.269010.0000AID210168
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (9)

Processvia Protein(s)Taxonomy
neutrophil homeostasisThrombopoietin receptorHomo sapiens (human)
monocyte homeostasisThrombopoietin receptorHomo sapiens (human)
positive regulation of lymphocyte proliferationThrombopoietin receptorHomo sapiens (human)
cellular response to hypoxiaThrombopoietin receptorHomo sapiens (human)
positive regulation of platelet formationThrombopoietin receptorHomo sapiens (human)
eosinophil homeostasisThrombopoietin receptorHomo sapiens (human)
basophil homeostasisThrombopoietin receptorHomo sapiens (human)
thrombopoietin-mediated signaling pathwayThrombopoietin receptorHomo sapiens (human)
immunoglobulin mediated immune responseThrombopoietin receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
protein bindingThrombopoietin receptorHomo sapiens (human)
thrombopoietin receptor activityThrombopoietin receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (6)

Processvia Protein(s)Taxonomy
Golgi apparatusThrombopoietin receptorHomo sapiens (human)
plasma membraneThrombopoietin receptorHomo sapiens (human)
cell surfaceThrombopoietin receptorHomo sapiens (human)
nuclear membraneThrombopoietin receptorHomo sapiens (human)
neuronal cell bodyThrombopoietin receptorHomo sapiens (human)
external side of plasma membraneThrombopoietin receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID210168Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells2001Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis.
AID1397965Inhibition of glycolate oxidase in C57BL/6 Agxt1-/- mouse hepatocytes using glycolate as substrate assessed as relative oxalate level at 10 uM after 24 hrs2018Journal of medicinal chemistry, 08-23, Volume: 61, Issue:16
Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1.
AID210169Thrombopoietin luciferase activity in BAF-3 cells2001Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis.
AID1397963Inhibition of mouse recombinant glycolate oxidase expressed in Escherichia coli at 25 uM using glycolate as substrate after 1 min by sulfonated DCIP dye-based assay relative to control2018Journal of medicinal chemistry, 08-23, Volume: 61, Issue:16
Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's4 (44.44)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 51.24

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index51.24 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.61 (4.65)
Search Engine Demand Index75.30 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (51.24)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (11.11%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (88.89%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]