Assay ID | Title | Year | Journal | Article |
AID662447 | Cytotoxicity against human HuH7 cells after 24 hrs by MTS assay | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors. |
AID1191708 | Antiviral activity against HCV genotype 1a infected in human HuH7 cells by replicon based assay | 2015 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 25, Issue:5
| Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors. |
AID1191710 | Inhibition of HCV genotype 1b NS5B RNA dependent RNA polymerase assessed as reduction in triphosphate activity | 2015 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 25, Issue:5
| Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors. |
AID1463866 | Antiviral activity against HCV genotype 1b Con1 expressing NS3 protease infected in human Huh-7 cells assessed as reduction in viral RNA replication after 72 hrs by luciferase reporter gene assay | 2017 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 27, Issue:18
| The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-α-chloro-2'-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors. |
AID1463867 | Cytotoxicity against human HuH7 cells assessed as reduction in cell viability | 2017 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 27, Issue:18
| The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-α-chloro-2'-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors. |
AID1191709 | Antiviral activity against HCV genotype 1b infected in human HuH7 cells by replicon based assay | 2015 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 25, Issue:5
| Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors. |
AID662448 | Inhibition of HCV genotype 1b NS5B after 90 mins | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors. |
AID662446 | Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as cytoprotection after 24 hrs | 2012 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
| Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |