geiparvarin and Colonic-Neoplasms

geiparvarin has been researched along with Colonic-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for geiparvarin and Colonic-Neoplasms

Article	Year
Some geiparvarin bioisosteres and homologues: synthesis and biological evaluation against human colon carcinoma cells (LoVo). Anti-cancer drug design, 1997, Volume: 12, Issue:2 Some geiparvarin bioisosteres and homologues are described. The compounds were tested on LoVo cells (human colon carcinoma cell line). The EC50 values of the synthesized compounds ranged from 35.04 microM (compound 3) to 11.88 microM (compound 4), while the EC50 value of geiparvarin 1 was 13.30 microM. Topics: Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Coumarins; Drug Screening Assays, Antitumor; Humans; Isomerism; Structure-Activity Relationship; Tumor Cells, Cultured	1997
Synthesis, cytotoxicity and SAR of simple geiparvarin analogues. Anti-cancer drug design, 1997, Volume: 12, Issue:6 Some simple geiparvarin analogues, in which the coumarin moiety has been replaced with an X-substituted benzene ring, are described. The compounds were tested on LoVo cells (human colon carcinoma cell line) and some of them show a cytotoxicity comparable with that of the prototype. A QSAR analysis was also attempted, but it did not provide satisfactory results, mainly because of the limited range of variation of the biological activity. Topics: Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Coumarins; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Structure-Activity Relationship; Tumor Cells, Cultured	1997

Article

Year

Some geiparvarin bioisosteres and homologues: synthesis and biological evaluation against human colon carcinoma cells (LoVo).

Anti-cancer drug design, 1997, Volume: 12, Issue:2

Some geiparvarin bioisosteres and homologues are described. The compounds were tested on LoVo cells (human colon carcinoma cell line). The EC50 values of the synthesized compounds ranged from 35.04 microM (compound 3) to 11.88 microM (compound 4), while the EC50 value of geiparvarin 1 was 13.30 microM.

Topics: Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Coumarins; Drug Screening Assays, Antitumor; Humans; Isomerism; Structure-Activity Relationship; Tumor Cells, Cultured

1997

Synthesis, cytotoxicity and SAR of simple geiparvarin analogues.

Anti-cancer drug design, 1997, Volume: 12, Issue:6

Some simple geiparvarin analogues, in which the coumarin moiety has been replaced with an X-substituted benzene ring, are described. The compounds were tested on LoVo cells (human colon carcinoma cell line) and some of them show a cytotoxicity comparable with that of the prototype. A QSAR analysis was also attempted, but it did not provide satisfactory results, mainly because of the limited range of variation of the biological activity.

Topics: Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Coumarins; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Structure-Activity Relationship; Tumor Cells, Cultured

1997