mitonafide has been researched along with Colonic-Neoplasms* in 2 studies
2 other study(ies) available for mitonafide and Colonic-Neoplasms
| Article | Year |
|---|---|
Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs.
A series of potential DNA-binding antitumor agents, 2-[omega-(alkylamino)alkyl]-6-{[omega-(alkylamino)alkyl]amino}-1H-benzo[de]isoquinolin-1,3(2H)-diones and 1,7-bis{6-[(omega-(dimethylamino)alkyl)amino]-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl}-4-methyl-4-azaheptanes, have been prepared as mitonafide derivatives. Their DNA-binding ability and cytotoxic activity have been evaluated. Some of the target compounds have shown high DNA affinity as well as relevant cytotoxic properties. Topics: Antineoplastic Agents; Aza Compounds; Colonic Neoplasms; DNA; Drug Design; HT29 Cells; Humans; Inhibitory Concentration 50; Intercalating Agents; Isoquinolines; Naphthalimides; Structure-Activity Relationship; Tumor Cells, Cultured | 2008 |
A new synthetic agent with potent but selective cytotoxic activity against cancer.
The synthesis of novel unsymmetrical bifunctional antitumor agents was accomplished by linking an imidazoacridone moiety to another polycyclic heteroaromatic moiety via linkers of various length and rigidity. These compounds bind to cellular DNA, but it is hypothesized that biological effects become manifested when the drug-DNA complexes interact with critical DNA binding proteins that are involved in repair and transcription. The most promising compound of the series, 4ad (WMC79), consists of an imidazoacridone linked to a 3-nitronaphthalimide moiety via a 1,4-dipropanopiperazine linker. It was found to be potently, but selectively, cytotoxic against colon cancers (GI(50) = 0.5 nM, LC(50) = 32 nM) and leukemias (GI(50) = 3.5 nM, LC(50) = 33 nM). Compound 4ad, which appears to be a candidate for further development as an anticancer drug, kills sensitive cells by induction of apoptosis. It also showed significant in vivo activity against HCT-116 colon cancer xenografts in nude mice. Other compounds in the series also exhibited antitumor properties, but they were significantly lower than that of 4ad. Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Small Cell; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; DNA Fragmentation; DNA, Neoplasm; Female; HL-60 Cells; Humans; Lung Neoplasms | 2005 |