mbx-1066 and indole

mbx-1066 has been researched along with indole* in 2 studies

Other Studies

2 other study(ies) available for mbx-1066 and indole

ArticleYear
Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090.
    Bioorganic & medicinal chemistry, 2013, Dec-15, Volume: 21, Issue:24

    The prevalence of drug-resistant bacteria in the clinic has propelled a concerted effort to find new classes of antibiotics that will circumvent current modes of resistance. We have previously described a set of bisamidine antibiotics that contains a core composed of two indoles and a central linker. The first compounds of the series, MBX 1066 and MBX 1090, have potent antibacterial properties against a wide range of Gram-positive and Gram-negative bacteria. We have conducted a systematic exploration of the amidine functionalities, the central linker, and substituents at the indole 3-position to determine the factors involved in potent antibacterial activity. Some of the newly synthesized compounds have even more potent and broad-spectrum activity than MBX 1066 and MBX 1090.

    Topics: Anti-Bacterial Agents; Bacteria; Dose-Response Relationship, Drug; Furans; Imidazoles; Indoles; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship

2013
Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9

    Antimicrobial susceptibilities of 233 gram-positive and 180 gram-negative strains to two novel bis-indoles were evaluated. Both compounds were potent inhibitors of gram-positive bacteria, with MIC(90) values of 0.004 to 0.5 microg/ml. One bis-indole, MBX 1162, exhibited potent activity against all gram-negative strains, with MIC(90) values of 0.12 to 4 microg/ml, even against high-level-resistant pathogens, and compared favorably to all comparator antibiotics. The bis-indole compounds show promise for the treatment of multidrug-resistant clinical pathogens.

    Topics: Anti-Bacterial Agents; Gram-Negative Aerobic Bacteria; Gram-Positive Bacteria; Indoles; Microbial Sensitivity Tests

2010
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