Page last updated: 2024-12-10

chuangxinmycin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

chuangxinmycin: produced by Actinoplanes tsinanensis; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

(-)-chuangxinmycin : A thiinoindole that is 3,5-dihydro-2H-thiino[4,3,2-cd]indole which is substituted at positions 2 and 3 by carboxy and methyl groups, respectively (the 2R,3S diastereoisomer). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID3037261
CHEMBL ID320316
CHEBI ID79391
SCHEMBL ID117509
MeSH IDM0062927

Synonyms (16)

Synonym
2h-thiopyrano(4,3,2-cd)indole-2-carboxylic acid, 3,5-dihydro-3-methyl-, cis-(-)-
chuanghsinmycin
cis-(-)-3,5-dihydro-3-methyl-2h-thiopyrano(4,3,2-cd)indole-2-carboxylic acid
chuangxinmycin
CHEMBL320316
chebi:79391 ,
63339-68-4
SCHEMBL117509
(-)-(4s,5r)-chuangxinmycin
(4s,5r)-(-)-chuangxinmycin
(-)-chuangxinmycin
(2r,3s)-3-methyl-3,5-dihydro-2h-thiino[4,3,2-cd]indole-2-carboxylic acid
DTXSID00212722
Q27148429
(5s,6r)-5-methyl-7-thia-2-azatricyclo[6.3.1.04,12]dodeca-1(12),3,8,10-tetraene-6-carboxylic acid
(2r,3s)-3-methyl-3,5-dihydro-2h-thiopyrano[4,3,2-cd]indole-2-carboxylic acid

Research Excerpts

Overview

Chuangxinmycin is a sulfur-containing antibiotic with a unique thiopyrano[4,3,2-cd]indole (TPI) skeleton and selective inhibitory activity against bacterial tryptophanyl-tRNA synthetase.

ExcerptReferenceRelevance
"Chuangxinmycin is a sulfur-containing antibiotic with a unique thiopyrano[4,3,2-cd]indole (TPI) skeleton and selective inhibitory activity against bacterial tryptophanyl-tRNA synthetase."( Biosynthesis of Chuangxinmycin Featuring a Deubiquitinase-like Sulfurtransferase.
Bian, X; Cheng, F; Du, L; Geng, C; Guo, J; Lan, H; Li, S; Li, Y; Sang, M; Shen, Y; Tang, YJ; Wang, S; Xu, X; Yang, C; Yang, F; You, C; Zhang, W; Zhang, X; Zhang, Y, 2021
)
1.69
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (4)

RoleDescription
EC 6.1.1.2 (tryptophan--tRNA ligase) inhibitorAn EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor that interferes with the action of any tryptophan--tRNA ligase (EC 6.1.1.2).
antibacterial agentA substance (or active part thereof) that kills or slows the growth of bacteria.
antimicrobial agentA substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
bacterial metaboliteAny prokaryotic metabolite produced during a metabolic reaction in bacteria.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
monocarboxylic acidAn oxoacid containing a single carboxy group.
thiinoindoleAny organic heterotricyclic compound that consists of a thiopyran ring fused to an indole.
indole alkaloidAn alkaloid containing an indole skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID214798Compound was tested for inhibitory activity against tryptophanyl tRNA synthetase in Staphylococcus aureus2002Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.
AID214800Binding affinity against Tryptophanyl tRNA synthetase was determined2002Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.
AID214797Compound was tested for inhibitory activity against tryptophanyl tRNA synthetase in Ovine WRS2002Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (36.84)18.7374
1990's1 (5.26)18.2507
2000's4 (21.05)29.6817
2010's3 (15.79)24.3611
2020's4 (21.05)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.58

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.58 (24.57)
Research Supply Index3.04 (2.92)
Research Growth Index4.99 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.58)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other19 (95.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]