fusarin-c and bikaverin

fusarin-c has been researched along with bikaverin* in 2 studies

Other Studies

2 other study(ies) available for fusarin-c and bikaverin

Article	Year
Aeration affects acetate destination in Gibberella fujikuroi. FEMS microbiology letters, 1999, Nov-01, Volume: 180, Issue:1 Gibberellins, fatty acids and the polyketides bikaverin and fusarin C are synthesized from a common precursor, acetyl-CoA. The production of these compounds in Gibberella fujikuroi was strongly influenced by aeration, determined by the air/medium ratio in shaken batch cultures. Higher aeration resulted in increased growth and the production of bikaverin and gibberellins. Low aeration stimulated fatty acid and fusarin C production. Feeding experiments with labeled leucine or acetate resulted in different proportions of labeled palmitic acid and bikaverin, indicating that these compounds are synthesized from independent acetate pools. Topics: Acetates; Air; Fatty Acids; Gibberella; Gibberellins; Hydrogen-Ion Concentration; Leucine; Polyenes; Xanthenes; Xanthones	1999
Effects of selected secondary metabolites of Fusarium moniliforme on unscheduled synthesis of DNA by rat primary hepatocytes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1992, Volume: 30, Issue:3 The Fusarium moniliforme mycotoxins--fusarin C, fumonisin B1, moniliformin and bikaverin--were evaluated for genotoxicity by their ability to induce unscheduled DNA synthesis (UDS) in primary rat hepatocytes. Isolated hepatocytes were exposed to several concentrations of moniliformin (5.0-500 microM), bikaverin (1.0-500 microM), fumonisin B1 (0.5-250 microM), or fusarin C (1.0-100 microM). Aflatoxin B1, a known inducer of UDS, was included as a positive control. UDS was determined by autoradiography of cells after their exposure to [3H]thymidine. The highest doses of fusarin C and bikaverin caused cell death, but no cytotoxicity was observed in cells exposed to moniliformin or fumonisin B1. Fumonisin B1, moniliformin and bikaverin were not genotoxic in the UDS assay. The results of the UDS assay with fusarin C were inconclusive since a marginal effect on UDS was obtained. Topics: Animals; Antineoplastic Agents; Culture Techniques; Cyclobutanes; DNA; Fumonisins; Fusarium; Liver; Male; Mutagens; Mycotoxins; Polyenes; Rats; Rats, Inbred Strains; Xanthenes; Xanthones	1992

Article

Year

Aeration affects acetate destination in Gibberella fujikuroi.

FEMS microbiology letters, 1999, Nov-01, Volume: 180, Issue:1

Gibberellins, fatty acids and the polyketides bikaverin and fusarin C are synthesized from a common precursor, acetyl-CoA. The production of these compounds in Gibberella fujikuroi was strongly influenced by aeration, determined by the air/medium ratio in shaken batch cultures. Higher aeration resulted in increased growth and the production of bikaverin and gibberellins. Low aeration stimulated fatty acid and fusarin C production. Feeding experiments with labeled leucine or acetate resulted in different proportions of labeled palmitic acid and bikaverin, indicating that these compounds are synthesized from independent acetate pools.

Topics: Acetates; Air; Fatty Acids; Gibberella; Gibberellins; Hydrogen-Ion Concentration; Leucine; Polyenes; Xanthenes; Xanthones

1999

Effects of selected secondary metabolites of Fusarium moniliforme on unscheduled synthesis of DNA by rat primary hepatocytes.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1992, Volume: 30, Issue:3

The Fusarium moniliforme mycotoxins--fusarin C, fumonisin B1, moniliformin and bikaverin--were evaluated for genotoxicity by their ability to induce unscheduled DNA synthesis (UDS) in primary rat hepatocytes. Isolated hepatocytes were exposed to several concentrations of moniliformin (5.0-500 microM), bikaverin (1.0-500 microM), fumonisin B1 (0.5-250 microM), or fusarin C (1.0-100 microM). Aflatoxin B1, a known inducer of UDS, was included as a positive control. UDS was determined by autoradiography of cells after their exposure to [3H]thymidine. The highest doses of fusarin C and bikaverin caused cell death, but no cytotoxicity was observed in cells exposed to moniliformin or fumonisin B1. Fumonisin B1, moniliformin and bikaverin were not genotoxic in the UDS assay. The results of the UDS assay with fusarin C were inconclusive since a marginal effect on UDS was obtained.

Topics: Animals; Antineoplastic Agents; Culture Techniques; Cyclobutanes; DNA; Fumonisins; Fusarium; Liver; Male; Mutagens; Mycotoxins; Polyenes; Rats; Rats, Inbred Strains; Xanthenes; Xanthones

1992