fusarin-c and Breast-Neoplasms

Fusarin C is a mycotoxin produced by several Fusarium species and has been associated with esophageal cancer due to its carcinogenic effects. Here, we report that fusarin C stimulates growth of the breast cancer cell line MCF-7. This suggests that fusarin C can act as an estrogenic agonist and should be classified as a mycoestrogen. MCF-7 cells were stimulated in the range between 0.1 and 20μM and inhibited when the concentration exceeded 50μM. The toxicity of fusarin C is comparable to other mycoestrogens such as zearalenone, but the chemical structure of fusarin C is very different from other known estrogen agonists. Furthermore, the toxicity of fusarin C was tested in five additional human cell lines Caco 2, U266, PC3, MDA-MB-231 and MCF-10a which were all inhibited when the concentration of fusarin C exceeded 10μM. To the best of our knowledge this is the first report on the mycoestrogenic properties of fusarin C.

Topics: Breast Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Fusarium; Humans; Inhibitory Concentration 50; Molecular Structure; Polyenes; Recombinant Proteins