botrydial: is produced in plant tissues infected by Botrytis cinerea; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
botrydial : A cytotoxic fungal metabolite isolated from plant tissues infected by phytopathogen Botrytis cinerea. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 185781 |
| CHEMBL ID | 476877 |
| CHEBI ID | 3159 |
| SCHEMBL ID | 7708121 |
| MeSH ID | M0395797 |
| Synonym |
|---|
| CHEBI:3159 , |
| (1s,3ar,4s,6r,7s,7as)-1,7-diformyl-7a-hydroxy-1,3,3,6-tetramethyloctahydro-1h-inden-4-yl acetate |
| 54986-75-3 |
| botrydial |
| C09622 |
| LMPR0103640001 |
| CHEMBL476877 |
| unii-2vqe1z1g8q |
| ((1s,3ar,4s,6r,7s,7ar)-1,7-diformyl-7a-hydroxy-1,3,3,6-tetramethyl-2,3a,4,5,6,7-hexahydroinden-4-yl) acetate |
| 2vqe1z1g8q , |
| SCHEMBL7708121 |
| (1s,3ar,4s,6r,7s,7as)-4-(acetyloxy)octahydro-7a-hydroxy-1,3,3,6-tetramethyl-1h-indene-1,7-dicarboxaldehyde |
| botrydial [mi] |
| 1h-indene-1,7-dicarboxaldehyde, 4-(acetyloxy)octahydro-7a-hydroxy-1,3,3,6-tetramethyl-, (1s,3ar,4s,6r,7s,7as)- |
| Q4948811 |
| DTXSID20970337 |
Botrydial is a phytotoxic sesquiterpene generated by the necrotrophic fungus Botrytis cinerea. Botrydial induces diverse plant defense responses, such as the production of reactive oxygen species (ROS)
| Excerpt | Reference | Relevance |
|---|---|---|
| "Botrydial is a phytotoxic sesquiterpene generated by the necrotrophic fungus Botrytis cinerea that induces diverse plant defense responses, such as the production of reactive oxygen species (ROS)." | ( The sesquiterpene botrydial from Botrytis cinerea induces phosphatidic acid production in tomato cell suspensions. Collado, IG; D'Ambrosio, JM; Di Palma, AA; Gonorazky, G; Lamattina, L; Laxalt, AM; Moraga, J; Sueldo, DJ, 2018) | 1.54 |
| "Botrydial (BOT) is a non-host specific phytotoxin produced by the polyphagous phytopathogenic fungus Botrytis cinerea. " | ( The botrydial biosynthetic gene cluster of Botrytis cinerea displays a bipartite genomic structure and is positively regulated by the putative Zn(II) Amselem, J; Collado, IG; Dalmais, B; Luyten, I; Moraga, J; Morgant, G; Porquier, A; Pradier, JM; Simon, A; Viaud, M, 2016) | 2.44 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Upon botrydial treatments, SlPLC2-silenced-cell suspensions produce PA levels similar to wild-type cells." | ( The sesquiterpene botrydial from Botrytis cinerea induces phosphatidic acid production in tomato cell suspensions. Collado, IG; D'Ambrosio, JM; Di Palma, AA; Gonorazky, G; Lamattina, L; Laxalt, AM; Moraga, J; Sueldo, DJ, 2018) | 1.27 |
| Role | Description |
|---|---|
| mycotoxin | Poisonous substance produced by fungi. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| dialdehyde | Any aldehyde with two aldehyde groups. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID336743 | Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay | 2003 | Journal of natural products, Mar, Volume: 66, Issue:3 | Chemical transformations on botryane skeleton. Effect on the cytotoxic activity. |
| AID336742 | Cytotoxicity against human U87MG cells after 24 hrs by MTT assay | 2003 | Journal of natural products, Mar, Volume: 66, Issue:3 | Chemical transformations on botryane skeleton. Effect on the cytotoxic activity. |
| AID336739 | Cytotoxicity against HUVEC after 24 hrs by MTT assay | 2003 | Journal of natural products, Mar, Volume: 66, Issue:3 | Chemical transformations on botryane skeleton. Effect on the cytotoxic activity. |
| AID336740 | Cytotoxicity against human HT1080 cells after 24 hrs by MTT assay | 2003 | Journal of natural products, Mar, Volume: 66, Issue:3 | Chemical transformations on botryane skeleton. Effect on the cytotoxic activity. |
| AID336741 | Cytotoxicity against human Hs 578T cells after 24 hrs by MTT assay | 2003 | Journal of natural products, Mar, Volume: 66, Issue:3 | Chemical transformations on botryane skeleton. Effect on the cytotoxic activity. |
| AID336738 | Cytotoxicity against human IMR90 cells after 24 hrs by MTT assay | 2003 | Journal of natural products, Mar, Volume: 66, Issue:3 | Chemical transformations on botryane skeleton. Effect on the cytotoxic activity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 10 (58.82) | 24.3611 |
| 2020's | 3 (17.65) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (26.72) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 17 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||