Page last updated: 2024-12-08
barbigerone
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
barbigerone: an antioxidant; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 156793 |
| CHEMBL ID | 3311038 |
| SCHEMBL ID | 5094581 |
| MeSH ID | M0539739 |
Synonyms (18)
| Synonym |
|---|
| 4h,8h-benzo(1,2-b:3,4-b')dipyran-4-one, 8,8-dimethyl-3-(2,4,5-trimethoxyphenyl)- |
| barbigerone |
| LMPK12050076 |
| 8,8-dimethyl-3-(2,4,5-trimethoxyphenyl)pyrano[2,3-f]chromen-4-one |
| 9be3f2b4gd , |
| 75425-27-3 |
| unii-9be3f2b4gd |
| SCHEMBL5094581 |
| CHEMBL3311038 , |
| DTXSID30226352 |
| bdbm50505210 |
| ncgc00386021-01!8,8-dimethyl-3-(2,4,5-trimethoxyphenyl)pyrano[2,3-f]chromen-4-one |
| Q4859690 |
| j6l , |
| ionchocarpusone |
| 4h,8h-benzo[1,2-b:3,4-b']dipyran-4-one, 8,8-dimethyl-3-(2,4,5-trimethoxyphenyl)- |
| 8,8-dimethyl-3-(2,4,5-trimethoxyphenyl)-4h,8h-benzo(1,2-b:3,4-b')dipyran-4-one |
| AKOS040745595 |
Research Excerpts
Overview
Barbigerone is a naturally occurring isoflavone with antioxidant activity. It is mainly found in the genus Milletti, such as the edible leguminous plant Millettia ferruginea.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Barbigerone is an isoflavone mainly found in the genus Milletti, such as the edible leguminous plant Millettia ferruginea, with anticancer activity. " | ( Crystal structure of tubulin-barbigerone complex enables rational design of potent anticancer agents with isoflavone skeleton. Chen, L; Li, Y; Liu, Y; Pei, H; Wen, Y; Yan, W; Yang, J, 2023) | 2.64 |
| "Barbigerone is a naturally occurring isoflavone with antioxidant activity. " | ( Barbigerone, a natural isoflavone, induces apoptosis in murine lung-cancer cells via the mitochondrial apoptotic pathway. Cao, ZX; Chen, LJ; Jiang, PD; Li, ZG; Mao, YQ; Peng, A; Wei, YQ; Wu, X; Ye, HY; Zhao, X; Zhao, YL; Zheng, YZ, 2009) | 3.24 |
Actions
| Excerpt | Reference | Relevance |
|---|---|---|
| "Both barbigerone and 0412 inhibit cancer cell proliferation, tubulin polymerization, migration of HeLa cells and capillary-like tube formation of HUVECs, induce G2/M phase cell cycle arrest and apoptosis, and exhibit anticancer activity in an H460 xenograft model." | ( Crystal structure of tubulin-barbigerone complex enables rational design of potent anticancer agents with isoflavone skeleton. Chen, L; Li, Y; Liu, Y; Pei, H; Wen, Y; Yan, W; Yang, J, 2023) | 1.66 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (2)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Cholinesterase | Homo sapiens (human) | IC50 (µMol) | 21.7700 | 0.0000 | 1.5599 | 10.0000 | AID1524946 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 (µMol) | 121.6000 | 0.0000 | 0.9332 | 10.0000 | AID1524945 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (25)
Molecular Functions (15)
Ceullar Components (16)
Bioassays (19)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1524947 | Selectivity index, ratio of IC50 for inhibition of AChE (unknown origin) to IC50 for inhibition of BChE (unknown origin) | 2019 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 29, Issue:10 | Bioactivity-guided identification of flavonoids with cholinesterase and β-amyloid peptide aggregation inhibitory effects from the seeds of Millettia pachycarpa. |
| AID1178590 | Antimigratory activity in HUVEC assessed as migration into wound area at 1 uM after 24 hrs relative to vehicle treated control | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14 | Synthesis, structure-activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents. |
| AID1524946 | Inhibition of BChE (unknown origin) using butyrylthiocholine iodide as substrate by spectrophotometry based Ellman's method | 2019 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 29, Issue:10 | Bioactivity-guided identification of flavonoids with cholinesterase and β-amyloid peptide aggregation inhibitory effects from the seeds of Millettia pachycarpa. |
| AID1524944 | Inhibition of BChE (unknown origin) at 20 ug/mL using butyrylthiocholine iodide as substrate by spectrophotometry based Ellman's method | 2019 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 29, Issue:10 | Bioactivity-guided identification of flavonoids with cholinesterase and β-amyloid peptide aggregation inhibitory effects from the seeds of Millettia pachycarpa. |
| AID1524943 | Inhibition of AChE (unknown origin) at 20 ug/mL using acetylthiocholine iodide as substrate by spectrophotometry based Ellman's method | 2019 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 29, Issue:10 | Bioactivity-guided identification of flavonoids with cholinesterase and β-amyloid peptide aggregation inhibitory effects from the seeds of Millettia pachycarpa. |
| AID1524945 | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by spectrophotometry based Ellman's method | 2019 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 29, Issue:10 | Bioactivity-guided identification of flavonoids with cholinesterase and β-amyloid peptide aggregation inhibitory effects from the seeds of Millettia pachycarpa. |
| AID1178592 | Antiangiogenic activity against HUVEC assessed as inhibition of capillary-like tube formation at 5 uM after 8 hrs by Matrigel assay relative to control | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14 | Synthesis, structure-activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents. |
| AID1178589 | Antimigratory activity in HUVEC assessed as migration into wound area at 0.5 uM after 24 hrs relative to vehicle treated control | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14 | Synthesis, structure-activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents. |
| AID1178585 | Antiproliferative activity against mouse B16 cells after 24 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14 | Synthesis, structure-activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents. |
| AID1178591 | Antiangiogenic activity against HUVEC assessed as inhibition of capillary-like tube formation at 1 uM after 8 hrs by Matrigel assay relative to control | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14 | Synthesis, structure-activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents. |
| AID1524955 | Inhibition of amyloid beta (1 to 42) (unknown origin) self-aggregation at 80 uM incubated for 48 hrs by thioflavin-T fluorescence method | 2019 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 29, Issue:10 | Bioactivity-guided identification of flavonoids with cholinesterase and β-amyloid peptide aggregation inhibitory effects from the seeds of Millettia pachycarpa. |
| AID1178587 | Antiproliferative activity against HUVEC after 24 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14 | Synthesis, structure-activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents. |
| AID1524953 | Inhibition of amyloid beta (1 to 42) (unknown origin) self-aggregation at 20 uM incubated for 48 hrs by thioflavin-T fluorescence method | 2019 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 29, Issue:10 | Bioactivity-guided identification of flavonoids with cholinesterase and β-amyloid peptide aggregation inhibitory effects from the seeds of Millettia pachycarpa. |
| AID1178588 | Antiangiogenic activity in Flk-1-GFP transgenic zebrafish embryo after 24 hrs | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14 | Synthesis, structure-activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents. |
| AID1178584 | Antiproliferative activity against human U251 cells after 24 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14 | Synthesis, structure-activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents. |
| AID1178582 | Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14 | Synthesis, structure-activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents. |
| AID1524954 | Inhibition of amyloid beta (1 to 42) (unknown origin) self-aggregation at 40 uM incubated for 48 hrs by thioflavin-T fluorescence method | 2019 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 29, Issue:10 | Bioactivity-guided identification of flavonoids with cholinesterase and β-amyloid peptide aggregation inhibitory effects from the seeds of Millettia pachycarpa. |
| AID1178586 | Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14 | Synthesis, structure-activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents. |
| AID1178583 | Antiproliferative activity against human A375 cells after 24 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14 | Synthesis, structure-activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (10)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 8 (80.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 17.81
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (17.81) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||