hupC protein, Bacteria: from structural operon of Rhizobium leguminosarum bv. viciae; MW 27.9 kDa; has hydrogenase activity; amino acid sequence given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 10198698 |
CHEMBL ID | 2409142 |
SCHEMBL ID | 17278937 |
MeSH ID | M0202031 |
Synonym |
---|
protein (rhizobium leguminosarum viceae clone palw8 gene hupc) |
hydrogenase b-type cytochrome subunit hupc protein, bacteria |
protein (rhizobium leguminosarum viceae clone palw8 gene hupc reduced) |
147416-32-8 |
hupc protein, bacteria |
CHEMBL2409142 |
SCHEMBL17278937 |
hupc protein |
(5r,9r,11r)-5-amino-7-methyl-11-vinyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1h)-one |
(1r,9r,13r)-1-amino-13-ethenyl-11-methyl-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one |
HY-122957 |
CS-0090709 |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Acetylcholinesterase | Homo sapiens (human) | IC50 (µMol) | 0.4890 | 0.0000 | 0.9332 | 10.0000 | AID763025 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Process | via Protein(s) | Taxonomy |
---|---|---|
amyloid-beta binding | Acetylcholinesterase | Homo sapiens (human) |
acetylcholinesterase activity | Acetylcholinesterase | Homo sapiens (human) |
cholinesterase activity | Acetylcholinesterase | Homo sapiens (human) |
protein binding | Acetylcholinesterase | Homo sapiens (human) |
collagen binding | Acetylcholinesterase | Homo sapiens (human) |
hydrolase activity | Acetylcholinesterase | Homo sapiens (human) |
serine hydrolase activity | Acetylcholinesterase | Homo sapiens (human) |
acetylcholine binding | Acetylcholinesterase | Homo sapiens (human) |
protein homodimerization activity | Acetylcholinesterase | Homo sapiens (human) |
laminin binding | Acetylcholinesterase | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Process | via Protein(s) | Taxonomy |
---|---|---|
extracellular region | Acetylcholinesterase | Homo sapiens (human) |
basement membrane | Acetylcholinesterase | Homo sapiens (human) |
extracellular space | Acetylcholinesterase | Homo sapiens (human) |
nucleus | Acetylcholinesterase | Homo sapiens (human) |
Golgi apparatus | Acetylcholinesterase | Homo sapiens (human) |
plasma membrane | Acetylcholinesterase | Homo sapiens (human) |
cell surface | Acetylcholinesterase | Homo sapiens (human) |
membrane | Acetylcholinesterase | Homo sapiens (human) |
neuromuscular junction | Acetylcholinesterase | Homo sapiens (human) |
synaptic cleft | Acetylcholinesterase | Homo sapiens (human) |
synapse | Acetylcholinesterase | Homo sapiens (human) |
perinuclear region of cytoplasm | Acetylcholinesterase | Homo sapiens (human) |
side of membrane | Acetylcholinesterase | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID763022 | Mixed-type competitive inhibition of rat cortical AChE by Lineweaver-Burke plot analysis | 2013 | Journal of natural products, Aug-23, Volume: 76, Issue:8 | Casuarinines A-J, lycodine-type alkaloids from Lycopodiastrum casuarinoides. |
AID763025 | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate after 8 mins by Ellman's spectrophotometric method | 2013 | Journal of natural products, Aug-23, Volume: 76, Issue:8 | Casuarinines A-J, lycodine-type alkaloids from Lycopodiastrum casuarinoides. |
AID763024 | Reversible inhibition of rat cortical AChE up to 8 mins | 2013 | Journal of natural products, Aug-23, Volume: 76, Issue:8 | Casuarinines A-J, lycodine-type alkaloids from Lycopodiastrum casuarinoides. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 4 (57.14) | 18.2507 |
2000's | 1 (14.29) | 29.6817 |
2010's | 2 (28.57) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.55) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 7 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |