hupC protein, Bacteria: from structural operon of Rhizobium leguminosarum bv. viciae; MW 27.9 kDa; has hydrogenase activity; amino acid sequence given in first source [MeSH]
| ID Source | ID |
|---|---|
| PubMed CID | 10198698 |
| CHEMBL ID | 2409142 |
| SCHEMBL ID | 17278937 |
| MeSH ID | M0202031 |
| Synonym |
|---|
| protein (rhizobium leguminosarum viceae clone palw8 gene hupc) |
| hydrogenase b-type cytochrome subunit hupc protein, bacteria |
| protein (rhizobium leguminosarum viceae clone palw8 gene hupc reduced) |
| 147416-32-8 |
| hupc protein, bacteria |
| CHEMBL2409142 |
| SCHEMBL17278937 |
| hupc protein |
| (5r,9r,11r)-5-amino-7-methyl-11-vinyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1h)-one |
| (1r,9r,13r)-1-amino-13-ethenyl-11-methyl-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one |
| HY-122957 |
| CS-0090709 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) |
|---|---|---|---|---|
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 0.4890 | AID763025 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID763022 | Mixed-type competitive inhibition of rat cortical AChE by Lineweaver-Burke plot analysis | 2013 | Journal of natural products, Aug-23, Volume: 76, Issue:8 ISSN: 1520-6025 | Casuarinines A-J, lycodine-type alkaloids from Lycopodiastrum casuarinoides. |
| AID763025 | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate after 8 mins by Ellman's spectrophotometric method | 2013 | Journal of natural products, Aug-23, Volume: 76, Issue:8 ISSN: 1520-6025 | Casuarinines A-J, lycodine-type alkaloids from Lycopodiastrum casuarinoides. |
| AID763024 | Reversible inhibition of rat cortical AChE up to 8 mins | 2013 | Journal of natural products, Aug-23, Volume: 76, Issue:8 ISSN: 1520-6025 | Casuarinines A-J, lycodine-type alkaloids from Lycopodiastrum casuarinoides. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| acetylcysteine | acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid | antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary | 2013 | 2013 | 11.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| hydrogen | elemental hydrogen; elemental molecule; gas molecular entity | antioxidant; electron donor; food packaging gas; fuel; human metabolite | 1997 | 1997 | 27.0 | high | 0 | 0 | 2 | 0 | 0 | 0 | |
| oxazoles | 1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene | 2018 | 2018 | 6.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 | ||
| cytochrome c-t | 2018 | 2018 | 6.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 | |||
| vulnibactin | 2018 | 2018 | 6.0 | high | 0 | 0 | 0 | 0 | 1 | 0 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Neuroblastoma | 0 | 2013 | 2013 | 11.0 | high | 0 | 0 | 0 | 0 | 1 | 0 |