6-methoxydihydrosanguinarine: from Corydalis tashiroi (Fumariaceae); structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Flora | Rank | Flora Definition | Family | Family Definition |
---|---|---|---|---|
Corydalis | genus | A plant genus of the family FUMARIACEAE (classified by some in PAPAVERACEAE) that contains isoquinoline alkaloids.[MeSH] | Papaveraceae | The poppy plant family of the order Papaverales, subclass Magnoliidae, class Magnoliopsida. These have bisexual, regular, cup-shaped flowers with one superior pistil and many stamens; 2 or 3 conspicuous, separate sepals and a number of separate petals. The fruit is a capsule. Leaves are usually deeply cut or divided into leaflets.[MeSH] |
ID Source | ID |
---|---|
PubMed CID | 14847270 |
CHEMBL ID | 4171637 |
MeSH ID | M0403369 |
Synonym |
---|
bdbm50286635 |
chembl4171637 , |
72401-54-8 |
6-methoxydihydrosanguinarine |
AKOS030524962 |
[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine, 13,14-dihydro-14-methoxy-13-methyl- |
(-)-14-methoxy-13-methyl-13,14-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridine |
6-methoxydihydrosanguinarine72401-54-8 |
MS-25777 |
23-methoxy-24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-1(13),2,4(8),9,11,14(22),15,17(21)-octaene |
CS-0022888 |
HY-N3000 |
PD166537 |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Acetylcholinesterase | Homo sapiens (human) | IC50 (µMol) | 96.8000 | 0.0000 | 0.9332 | 10.0000 | AID1350115 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Process | via Protein(s) | Taxonomy |
---|---|---|
amyloid-beta binding | Acetylcholinesterase | Homo sapiens (human) |
acetylcholinesterase activity | Acetylcholinesterase | Homo sapiens (human) |
cholinesterase activity | Acetylcholinesterase | Homo sapiens (human) |
protein binding | Acetylcholinesterase | Homo sapiens (human) |
collagen binding | Acetylcholinesterase | Homo sapiens (human) |
hydrolase activity | Acetylcholinesterase | Homo sapiens (human) |
serine hydrolase activity | Acetylcholinesterase | Homo sapiens (human) |
acetylcholine binding | Acetylcholinesterase | Homo sapiens (human) |
protein homodimerization activity | Acetylcholinesterase | Homo sapiens (human) |
laminin binding | Acetylcholinesterase | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Process | via Protein(s) | Taxonomy |
---|---|---|
extracellular region | Acetylcholinesterase | Homo sapiens (human) |
basement membrane | Acetylcholinesterase | Homo sapiens (human) |
extracellular space | Acetylcholinesterase | Homo sapiens (human) |
nucleus | Acetylcholinesterase | Homo sapiens (human) |
Golgi apparatus | Acetylcholinesterase | Homo sapiens (human) |
plasma membrane | Acetylcholinesterase | Homo sapiens (human) |
cell surface | Acetylcholinesterase | Homo sapiens (human) |
membrane | Acetylcholinesterase | Homo sapiens (human) |
neuromuscular junction | Acetylcholinesterase | Homo sapiens (human) |
synaptic cleft | Acetylcholinesterase | Homo sapiens (human) |
synapse | Acetylcholinesterase | Homo sapiens (human) |
perinuclear region of cytoplasm | Acetylcholinesterase | Homo sapiens (human) |
side of membrane | Acetylcholinesterase | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID1694962 | Antiproliferative activity against human H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | 2020 | RSC medicinal chemistry, Feb-01, Volume: 11, Issue:2 | The synthesis and biological evaluation of sanguinarine derivatives as anti-non-small cell lung cancer agents. |
AID1694961 | Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | 2020 | RSC medicinal chemistry, Feb-01, Volume: 11, Issue:2 | The synthesis and biological evaluation of sanguinarine derivatives as anti-non-small cell lung cancer agents. |
AID1350115 | Inhibition of human erythrocyte AChE using S-acetylthiocholine iodide as substrate pretreated for 20 mins followed by substrate addition measured after 30 mins by Ellman's method | 2018 | Journal of natural products, 02-23, Volume: 81, Issue:2 | Mucroniferanines A-G, Isoquinoline Alkaloids from Corydalis mucronifera. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 3 (30.00) | 29.6817 |
2010's | 4 (40.00) | 24.3611 |
2020's | 3 (30.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.23) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 10 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |