| Assay ID | Title | Year | Journal | Article |
|---|
| AID1251513 | Inhibition of recombinant Anopheles gambiae wild type AChE by Ellman assay | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
| Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase. |
| AID1079946 | Presence of at least one case with successful reintroduction. [column 'REINT' in source] | | | |
| AID1251511 | Inhibition of Anopheles gambiae AChE G119S mutant after 10 mins by Ellman assay | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
| Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase. |
| AID1079939 | Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] | | | |
| AID1079945 | Animal toxicity known. [column 'TOXIC' in source] | | | |
| AID1251509 | Inhibition of recombinant Anopheles gambiae AChE G119S mutant after 60 mins by Ellman assay | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
| Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase. |
| AID1079937 | Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] | | | |
| AID1079942 | Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source] | | | |
| AID1079934 | Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] | | | |
| AID1079944 | Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source] | | | |
| AID1079938 | Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] | | | |
| AID1079949 | Proposed mechanism(s) of liver damage. [column 'MEC' in source] | | | |
| AID1079948 | Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] | | | |
| AID1251526 | Inhibition of recombinant human AChE by Ellman assay | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
| Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase. |
| AID1079943 | Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] | | | |
| AID1251508 | Inhibition of recombinant Anopheles gambiae wild type AChE after 60 mins by Ellman assay | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
| Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase. |
| AID1079940 | Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] | | | |
| AID1251510 | Inhibition of recombinant Anopheles gambiae wild type AChE after 10 mins by Ellman assay | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
| Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase. |
| AID1079933 | Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is | | | |
| AID1251515 | Insecticidal activity against Anopheles gambiae G3 assessed as torsal contact toxicity by measuring mortality at 1000 ug/mL after 24 hrs by filter paper based method | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
| Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase. |
| AID1079936 | Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] | | | |
| AID1251506 | Inhibition of recombinant human AChE after 10 mins by Ellman assay | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
| Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase. |
| AID1079947 | Comments (NB not yet translated). [column 'COMMENTAIRES' in source] | | | |
| AID1079932 | Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] | | | |
| AID1251507 | Inhibition of recombinant human AChE after 60 mins by Ellman assay | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
| Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase. |
| AID1079941 | Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] | | | |
| AID1079931 | Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] | | | |
| AID1079935 | Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] | | | |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |