chonemorphine: a steroidal alkaloid; antiparasitic agent from Chonemorpha fragrans [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Chonemorpha | genus | A plant genus of the family APOCYNACEAE. It contains chonemorphine, a steroidal alkaloid.[MeSH] | Apocynaceae | The dogbane family of the order Gentianales. Members of the family have milky, often poisonous juice, smooth-margined leaves, and flowers in clusters.[MeSH] |
| Chonemorpha fragrans | species | [no description available] | Apocynaceae | The dogbane family of the order Gentianales. Members of the family have milky, often poisonous juice, smooth-margined leaves, and flowers in clusters.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 165208 |
| CHEMBL ID | 498645 |
| SCHEMBL ID | 5425288 |
| MeSH ID | M0154125 |
| Synonym |
|---|
| chonemorphine |
| bdbm50272517 |
| CHEMBL498645 , |
| 4282-07-9 |
| pregnane-3,20-diamine, n20,n20-dimethyl-, (3beta,5alpha,20s)- |
| unii-3aym0ka3qk |
| 3aym0ka3qk , |
| pregnane-3,20-diamine, n20,n20-dimethyl-, (3.beta.,5.alpha.,20s)- |
| chonemorphine [mi] |
| 1390-91-6 |
| 5.alpha.-pregnane-3.beta.,20.alpha.-diamine, n20,n20-dimethyl- |
| SCHEMBL5425288 |
| Q27256983 |
| DTXSID40962714 |
| AKOS040740318 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " At a dosage of 100 mg/kg x 4 chonemorphine led to a 100% cure of experimental hepatic infection in golden hamsters and cleared 90% of the intestinal infection in weanling Wistar rats at 200 mg/kg (x4) dosages." | ( Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models. Chatterjee, DK; Ganguli, BN; Iyer, N, 1987) | 0.87 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Cholinesterase | Homo sapiens (human) | IC50 (µMol) | 0.5000 | 0.0000 | 1.5599 | 10.0000 | AID362528 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 (µMol) | 28.0000 | 0.0000 | 0.9332 | 10.0000 | AID362527 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID362540 | Antibacterial activity against Pseudomonas pallida by agar well diffusion method | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. |
| AID362539 | Antibacterial activity against Micrococcus luteus by agar well diffusion method | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. |
| AID362532 | Antibacterial activity against Streptococcus faecalis assessed as zone of inhibition at 1.0 mg/mL by agar well diffusion method | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. |
| AID362533 | Antibacterial activity against Pseudomonas pallida assessed as zone of inhibition at 1.0 mg/mL by agar well diffusion method | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. |
| AID362538 | Antibacterial activity against Bacillus subtilis by agar well diffusion method | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. |
| AID362531 | Antibacterial activity against Micrococcus luteus assessed as zone of inhibition at 1.0 mg/mL by agar well diffusion method | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. |
| AID362527 | Inhibition of acetylcholinesterase | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. |
| AID362528 | Inhibition of butyrylcholinesterase | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. |
| AID362530 | Antibacterial activity against Bacillus subtilis assessed as zone of inhibition at 1.0 mg/mL by agar well diffusion method | 2008 | Journal of natural products, Aug, Volume: 71, Issue:8 | Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||