Compounds > discorhabdin l
Page last updated: 2024-10-15

discorhabdin l

Description

discorhabdin L: cytotoxic alkaloid from the sponge Latrunculia brevis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID135451012
CHEMBL ID553245
MeSH IDM0465698

Synonyms (4)

Synonym
CHEMBL553245
1r-hydroxydiscorhabdin d
discorhabdin l
okkhnekjikrsmn-plzsghjksa-n
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
AcetylcholinesteraseElectrophorus electricus (electric eel)IC50 (µMol)25.70000.00000.94539.9400AID1507303
AcetylcholinesteraseElectrophorus electricus (electric eel)Ki15.00000.00121.25638.9000AID1507306
AcetylcholinesteraseHomo sapiens (human)IC50 (µMol)158.00000.00000.933210.0000AID1507304
CholinesteraseEquus caballus (horse)IC50 (µMol)531.00000.00002.22149.4000AID1507305
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (14)

Processvia Protein(s)Taxonomy
acetylcholine catabolic process in synaptic cleftAcetylcholinesteraseHomo sapiens (human)
regulation of receptor recyclingAcetylcholinesteraseHomo sapiens (human)
osteoblast developmentAcetylcholinesteraseHomo sapiens (human)
acetylcholine catabolic processAcetylcholinesteraseHomo sapiens (human)
cell adhesionAcetylcholinesteraseHomo sapiens (human)
nervous system developmentAcetylcholinesteraseHomo sapiens (human)
synapse assemblyAcetylcholinesteraseHomo sapiens (human)
receptor internalizationAcetylcholinesteraseHomo sapiens (human)
negative regulation of synaptic transmission, cholinergicAcetylcholinesteraseHomo sapiens (human)
amyloid precursor protein metabolic processAcetylcholinesteraseHomo sapiens (human)
positive regulation of protein secretionAcetylcholinesteraseHomo sapiens (human)
retina development in camera-type eyeAcetylcholinesteraseHomo sapiens (human)
acetylcholine receptor signaling pathwayAcetylcholinesteraseHomo sapiens (human)
positive regulation of cold-induced thermogenesisAcetylcholinesteraseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (10)

Processvia Protein(s)Taxonomy
amyloid-beta bindingAcetylcholinesteraseHomo sapiens (human)
acetylcholinesterase activityAcetylcholinesteraseHomo sapiens (human)
cholinesterase activityAcetylcholinesteraseHomo sapiens (human)
protein bindingAcetylcholinesteraseHomo sapiens (human)
collagen bindingAcetylcholinesteraseHomo sapiens (human)
hydrolase activityAcetylcholinesteraseHomo sapiens (human)
serine hydrolase activityAcetylcholinesteraseHomo sapiens (human)
acetylcholine bindingAcetylcholinesteraseHomo sapiens (human)
protein homodimerization activityAcetylcholinesteraseHomo sapiens (human)
laminin bindingAcetylcholinesteraseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (13)

Processvia Protein(s)Taxonomy
extracellular regionAcetylcholinesteraseHomo sapiens (human)
basement membraneAcetylcholinesteraseHomo sapiens (human)
extracellular spaceAcetylcholinesteraseHomo sapiens (human)
nucleusAcetylcholinesteraseHomo sapiens (human)
Golgi apparatusAcetylcholinesteraseHomo sapiens (human)
plasma membraneAcetylcholinesteraseHomo sapiens (human)
cell surfaceAcetylcholinesteraseHomo sapiens (human)
membraneAcetylcholinesteraseHomo sapiens (human)
neuromuscular junctionAcetylcholinesteraseHomo sapiens (human)
synaptic cleftAcetylcholinesteraseHomo sapiens (human)
synapseAcetylcholinesteraseHomo sapiens (human)
perinuclear region of cytoplasmAcetylcholinesteraseHomo sapiens (human)
side of membraneAcetylcholinesteraseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (21)

Assay IDTitleYearJournalArticle
AID400548Cytotoxicity against human SKOV3 cells by SRB assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis.
AID400546Cytotoxicity against human DU145 cells by SRB assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis.
AID1507306Reversible competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate measured over 5 mins by Dixon plot analysis2017European journal of medicinal chemistry, Aug-18, Volume: 136Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors.
AID1507307Reversible competitive inhibition of human AChE using acetylthiocholine iodide as substrate measured over 5 mins by Dixon plot analysis2017European journal of medicinal chemistry, Aug-18, Volume: 136Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors.
AID1507304Inhibition of human AChE using acetylthiocholine iodide as substrate measured over 5 mins by Ellman's method2017European journal of medicinal chemistry, Aug-18, Volume: 136Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors.
AID400549Cytotoxicity against human IGROV cells by SRB assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis.
AID400551Cytotoxicity against human SKBR3 cells by SRB assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis.
AID400556Cytotoxicity against human PANC1 cells by SRB assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis.
AID400550Cytotoxicity against human IGROV-ET cells by SRB assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis.
AID1507303Inhibition of electric eel AChE using acetylthiocholine iodide as substrate measured over 5 mins by Ellman's method2017European journal of medicinal chemistry, Aug-18, Volume: 136Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors.
AID1507305Reversible competitive inhibition of equine serum BChE using acetylthiocholine iodide as substrate measured over 5 mins by Ellman's method2017European journal of medicinal chemistry, Aug-18, Volume: 136Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors.
AID400559Cytotoxicity against human doxorubicin-resistant LoVo cells by SRB assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis.
AID400557Cytotoxicity against human HT-29 cells by SRB assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis.
AID400558Cytotoxicity against human LoVo cells by SRB assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis.
AID400553Cytotoxicity against human HMEC1 cells by SRB assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis.
AID404059Cytotoxicity against mouse P388 cells2005Journal of natural products, Dec, Volume: 68, Issue:12
Discorhabdin W, the first dimeric discorhabdin.
AID400547Cytotoxicity against human LNCAP cells by SRB assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis.
AID400554Cytotoxicity against human A549 cells by SRB assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis.
AID400555Cytotoxicity against human K562 cells by SRB assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis.
AID1507308Inhibition of equine serum BChE using acetylthiocholine iodide as substrate measured over 5 mins by Dixon plot analysis2017European journal of medicinal chemistry, Aug-18, Volume: 136Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors.
AID400552Cytotoxicity against human SK-MEL-28 cells by SRB assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
galantamine
Galantamine: A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.. galanthamine : A benzazepine alkaloid isolated from certain species of daffodils.		2.1510benzazepine alkaloid fundamental parent;
benzazepine alkaloid;
organic heterotetracyclic compound;
tertiary amino compound		antidote to curare poisoning;
cholinergic drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.0210
Angiogenesis, Pathologic
[description not available]		02.5520
Cancer of Prostate
[description not available]		02.5520
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.5520