Page last updated: 2024-10-06

Cholesterol biosynthesis pathway in hepatocytes

Proteins (5)

ProteinSynonymsTaxonomy
Oxysterols receptor LXR-betaLiver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptorHomo sapiens (human)
Lanosterol 14-alpha demethylaseLDM; EC 1.14.14.154; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylaseHomo sapiens (human)
Cytochrome P450 7A124-hydroxycholesterol 7-alpha-hydroxylase; 1.14.14.26; CYPVII; Cholesterol 7-alpha-hydroxylase; Cholesterol 7-alpha-monooxygenase; 1.14.14.23Homo sapiens (human)
Sterol regulatory element-binding protein 1SREBP-1; Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription factor 1Homo sapiens (human)
Hydroxymethylglutaryl-CoA synthase, cytoplasmicHMG-CoA synthase; EC 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthaseHomo sapiens (human)

Compounds (30)

CompoundDescription
CholesterolThe principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
squaleneA natural 30-carbon triterpene.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
presqualene monophosphatestructure in first source
zymostenolRN given refers to (3beta,5alpha)-isomer; RN for cpd without isomeric designation not available 9/88
isopentenyl pyrophosphatesubstrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells
24-hydroxycholesterol
4,4-dimethylcholesta-8,14-dien-3-olRN refers to (3beta,5alpha)-isomer; a meiosis-activating sterol
24,25-epoxycholesterolRn given refers to (3alpha,5beta)-isomer; structure given in first source
4-hydroxycholesterol
7-dehydrocholesterolRN given refers to (3beta)-isomer; structure; main provitamin in skin that is converted by sunlight to cholecalciferol (vitamin D3)
desmosterolAn intermediate in the synthesis of cholesterol.
24-dehydroprovitamin D3
24,25-dihydrolanosterol
4,4-dimethylcholesta-8,14,24-trienola meiosis activating sterol; RN given refers to (5alpha,3beta)-isomer
geranyl pyrophosphateRN given refers to (E)-isomer
Mevalonic AcidA dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions.
presqualene pyrophosphate
2,3-oxidosqualenean oxidized derivative of SQUALENE that can fold in several ways: chair-boat-chair-boat to LANOSTEROL; chair-chair-chair-boat to dammarane; or all chair to hopane and on to cycloartenol; RN given refers to (all-Z)-isomer
lathosterolRN given refers to (3beta,5alpha)-isomer
cholest-5-en-3 beta,7 alpha-diolsubstrate for hydroxysteroid dehydrogenase; RN given refers to (3beta,7alpha)-isomer
4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-olRN given refers to (3beta,5alpha)-isomer
lanosterolA triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. It is metabolized to CHOLESTEROL and CUCURBITACINS.
acetyl coenzyme aAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
25-hydroxycholesterol
7-ketocholesterolinhibits uptake of cholesterol in rabbit aorta
cholest-4-en-3-one
acetoacetyl coa
zymosterola 4,14-desmethyl intermediate between LANOSTEROL and CHOLESTEROL
cholest-5-ene-3 beta,26-diolisolated from human brain