Page last updated: 2024-10-06
Fluvastatin Action Pathway
Proteins (21)
| Protein | Synonyms | Taxonomy |
|---|---|---|
| Delta(24)-sterol reductase | EC 1.3.1.72; 24-dehydrocholesterol reductase; 3-beta-hydroxysterol Delta-24-reductase; Diminuto/dwarf1 homolog; Seladin-1 | Homo sapiens (human) |
| Squalene monooxygenase | EC 1.14.14.17; Squalene epoxidase; SE | Homo sapiens (human) |
| Delta(14)-sterol reductase TM7SF2 | Delta-14-SR; EC 1.3.1.70; 3-beta-hydroxysterol Delta (14)-reductase; Another new gene 1 protein; C-14 sterol reductase; C14SR; Putative sterol reductase SR-1; Sterol C14-reductase; Transmembrane 7 superfamily member 2 | Homo sapiens (human) |
| Geranylgeranyl pyrophosphate synthase | GGPP synthase; GGPPSase; EC 2.5.1.-; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; 2.5.1.1; Farnesyl diphosphate synthase; Farnesyltranstransferase; 2.5.1.29; Geranylgeranyl diphosphate synthase; Geranyltranstransferase; 2.5.1.10 | Homo sapiens (human) |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMG-CoA reductase; EC 1.1.1.34 | Homo sapiens (human) |
| Farnesyl pyrophosphate synthase | FPP synthase; FPS; EC 2.5.1.10; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; 2.5.1.1; Farnesyl diphosphate synthase; Geranyltranstransferase | Homo sapiens (human) |
| Sterol O-acyltransferase 1 | EC 2.3.1.26; Acyl-coenzyme A:cholesterol acyltransferase 1; ACAT-1; Cholesterol acyltransferase 1 | Homo sapiens (human) |
| Lysosomal acid lipase/cholesteryl ester hydrolase | Acid cholesteryl ester hydrolase; LAL; EC 3.1.1.13; Cholesteryl esterase; Lipase A; Sterol esterase | Homo sapiens (human) |
| Lanosterol 14-alpha demethylase | LDM; EC 1.14.14.154; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylase | Homo sapiens (human) |
| Squalene synthase | SQS; SS; EC 2.5.1.21; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase 1 | Homo sapiens (human) |
| Lanosterol synthase | EC 5.4.99.7; 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC; hOSC | Homo sapiens (human) |
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | EC 5.3.3.5; Cholestenol Delta-isomerase; Delta(8)-Delta(7) sterol isomerase; D8-D7 sterol isomerase; Emopamil-binding protein | Homo sapiens (human) |
| Diphosphomevalonate decarboxylase | EC 4.1.1.33; Mevalonate (diphospho)decarboxylase; MDDase; Mevalonate pyrophosphate decarboxylase | Homo sapiens (human) |
| 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 | 17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; 3-keto-steroid reductase; 1.1.1.270; Dihydrotestosterone oxidoreductase; 1.1.1.210; Estradiol 17-beta-dehydrogenase 7; 1.1.1.62; Short chain dehydrogenase/reductase family 37C member 1 | Homo sapiens (human) |
| Lathosterol oxidase | EC 1.14.19.20; C-5 sterol desaturase; Delta(7)-sterol 5-desaturase; Delta(7)-sterol C5(6)-desaturase; Lathosterol 5-desaturase; Sterol-C5-desaturase | Homo sapiens (human) |
| Isopentenyl-diphosphate Delta-isomerase 1 | EC 5.3.3.2; Isopentenyl pyrophosphate isomerase 1; IPP isomerase 1; IPPI1 | Homo sapiens (human) |
| Acetyl-CoA acetyltransferase, cytosolic | EC 2.3.1.9; Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase | Homo sapiens (human) |
| Mevalonate kinase | MK; EC 2.7.1.36 | Homo sapiens (human) |
| Phosphomevalonate kinase | PMKase; hPMK; EC 2.7.4.2 | Homo sapiens (human) |
| Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating | EC 1.1.1.170; Protein H105e3 | Homo sapiens (human) |
| Methylsterol monooxygenase 1 | EC 1.14.18.9; C-4 methylsterol oxidase; Sterol-C4-methyl oxidase | Homo sapiens (human) |
Compounds (31)
| Compound | Description |
|---|---|
| Orthophosphate | |
| Fluvastatin | An indole-heptanoic acid derivative that inhibits HMG COA REDUCTASE and is used to treat HYPERCHOLESTEROLEMIA. In contrast to other statins, it does not appear to interact with other drugs that inhibit CYP3A4. |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| cholecalciferol | Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24. |
| Adenosine Triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| Cholesterol | The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| palmitic acid | A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids. |
| Coenzyme A | |
| zymostenol | RN given refers to (3beta,5alpha)-isomer; RN for cpd without isomeric designation not available 9/88 |
| isopentenyl pyrophosphate | substrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells |
| 5-diphosphomevalonic acid | RN given refers to ion(1-) |
| 7-dehydrocholesterol | RN given refers to (3beta)-isomer; structure; main provitamin in skin that is converted by sunlight to cholecalciferol (vitamin D3) |
| desmosterol | An intermediate in the synthesis of cholesterol. |
| 24-dehydroprovitamin D3 | |
| 24,25-dihydrolanosterol | |
| 4,4-dimethylcholesta-8,14,24-trienol | a meiosis activating sterol; RN given refers to (5alpha,3beta)-isomer |
| farnesyl pyrophosphate | a sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation |
| geranyl pyrophosphate | RN given refers to (E)-isomer |
| Mevalonic Acid | A dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions. |
| lathosterol | RN given refers to (3beta,5alpha)-isomer |
| cholesta-5,8-dien-3 beta-ol | found in tissue of rats given AY 9944 |
| lanosterol | A triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. It is metabolized to CHOLESTEROL and CUCURBITACINS. |
| phosphomevalonate | |
| acetyl coenzyme a | Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. |
| creolin | from refined coal tar oils |
| pyrophosphate | |
| 3,3-dimethylallyl pyrophosphate | isomeric with isopentenyl pyrophosphate |
| zymosterol | a 4,14-desmethyl intermediate between LANOSTEROL and CHOLESTEROL |