| Protein | Synonyms | Taxonomy |
|---|
| C-8 sterol isomerase | EC 5.-.-.-; Delta-8--delta-7 sterol isomerase | Saccharomyces cerevisiae S288C |
| Lanosterol synthase | EC 5.4.99.7; 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC | Saccharomyces cerevisiae S288C |
| Hydroxymethylglutaryl-CoA synthase | HMG-CoA synthase; EC 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthase | Saccharomyces cerevisiae S288C |
| 3-keto-steroid reductase | EC 1.1.1.270 | Saccharomyces cerevisiae S288C |
| Squalene synthase | SQS; SS; EC 2.5.1.21; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase | Saccharomyces cerevisiae S288C |
| Squalene monooxygenase | EC 1.14.14.17; Squalene epoxidase; SE | Saccharomyces cerevisiae S288C |
| Delta(14)-sterol reductase | EC 1.3.1.70; C-14 sterol reductase; Sterol C14-reductase | Saccharomyces cerevisiae S288C |
| Methylsterol monooxygenase | EC 1.14.18.9; C-4 methylsterol oxidase; Sterol-C4-methyl oxidase | Saccharomyces cerevisiae S288C |
| Lanosterol 14-alpha demethylase | EC 1.14.14.154; CYPLI; Cytochrome P450 51; Cytochrome P450-14DM; Cytochrome P450-LIA1; Sterol 14-alpha demethylase | Saccharomyces cerevisiae S288C |
| Farnesyl pyrophosphate synthase | FPP synthase; FPS; EC 2.5.1.10; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; 2.5.1.1; Farnesyl diphosphate synthase; Geranyltranstransferase | Saccharomyces cerevisiae S288C |
| Cytochrome P450 61 | EC 1.14.19.41; C-22 sterol desaturase | Saccharomyces cerevisiae S288C |
| Mevalonate kinase | MK; MvK; EC 2.7.1.36; Ergosterol biosynthesis protein 12; Regulation of autonomous replication protein 1 | Saccharomyces cerevisiae S288C |
| Isopentenyl-diphosphate Delta-isomerase | EC 5.3.3.2; Isopentenyl pyrophosphate isomerase; IPP isomerase | Saccharomyces cerevisiae S288C |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 | HMG-CoA reductase 1; EC 1.1.1.34 | Saccharomyces cerevisiae S288C |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 | HMG-CoA reductase 2; EC 1.1.1.34 | Saccharomyces cerevisiae S288C |
| Acetyl-CoA acetyltransferase | EC 2.3.1.9; Acetoacetyl-CoA thiolase; Ergosterol biosynthesis protein 10 | Saccharomyces cerevisiae S288C |
| Delta(7)-sterol 5(6)-desaturase | EC 1.14.19.20; C-5 sterol desaturase; Ergosterol Delta(5,6) desaturase; Sterol-C5-desaturase | Saccharomyces cerevisiae S288C |
| Delta(24(24(1)))-sterol reductase | EC 1.3.1.71; C-24(28) sterol reductase; Sterol Delta(24(28))-reductase | Saccharomyces cerevisiae S288C |
| Sterol 24-C-methyltransferase | EC 2.1.1.41; Delta(24)-sterol C-methyltransferase | Saccharomyces cerevisiae S288C |
| Phosphomevalonate kinase | EC 2.7.4.2 | Saccharomyces cerevisiae S288C |
| Diphosphomevalonate decarboxylase | EC 4.1.1.33; Ergosterol biosynthesis protein 19; Mevalonate pyrophosphate decarboxylase; Mevalonate-5-diphosphate decarboxylase; MDD; MDDase | Saccharomyces cerevisiae S288C |
| Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating | EC 1.1.1.170 | Saccharomyces cerevisiae S288C |
| Compound | Description |
|---|
| hydronium ion | |
| Orthophosphate | |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| Adenosine Triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| Cholesterol | The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| Coenzyme A | |
| isopentenyl pyrophosphate | substrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells |
| 5-diphosphomevalonic acid | RN given refers to ion(1-) |
| desmosterol | An intermediate in the synthesis of cholesterol. |
| fecosterol | RN given refers to (3beta,5alpha)-isomer |
| 24-dehydroprovitamin D3 | |
| 4,4-dimethylcholesta-8,14,24-trienol | a meiosis activating sterol; RN given refers to (5alpha,3beta)-isomer |
| farnesyl pyrophosphate | a sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation |
| geranyl pyrophosphate | RN given refers to (E)-isomer |
| Mevalonic Acid | A dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions. |
| lanosterol | A triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. It is metabolized to CHOLESTEROL and CUCURBITACINS. |
| s-adenosylmethionine | Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) |
| phosphomevalonate | |
| acetyl coenzyme a | Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. |
| creolin | from refined coal tar oils |
| pyrophosphate | |
| 3,3-dimethylallyl pyrophosphate | isomeric with isopentenyl pyrophosphate |
| zymosterol | a 4,14-desmethyl intermediate between LANOSTEROL and CHOLESTEROL |