Pathways > Cholesterol Biosynthesis and Metabolism
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Cholesterol Biosynthesis and Metabolism

Proteins (22)

ProteinSynonymsTaxonomy
C-8 sterol isomeraseEC 5.-.-.-; Delta-8--delta-7 sterol isomeraseSaccharomyces cerevisiae S288C
Lanosterol synthaseEC 5.4.99.7; 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSCSaccharomyces cerevisiae S288C
Hydroxymethylglutaryl-CoA synthaseHMG-CoA synthase; EC 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthaseSaccharomyces cerevisiae S288C
3-keto-steroid reductaseEC 1.1.1.270Saccharomyces cerevisiae S288C
Squalene synthaseSQS; SS; EC 2.5.1.21; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferaseSaccharomyces cerevisiae S288C
Squalene monooxygenaseEC 1.14.14.17; Squalene epoxidase; SESaccharomyces cerevisiae S288C
Delta(14)-sterol reductaseEC 1.3.1.70; C-14 sterol reductase; Sterol C14-reductaseSaccharomyces cerevisiae S288C
Methylsterol monooxygenaseEC 1.14.18.9; C-4 methylsterol oxidase; Sterol-C4-methyl oxidaseSaccharomyces cerevisiae S288C
Lanosterol 14-alpha demethylaseEC 1.14.14.154; CYPLI; Cytochrome P450 51; Cytochrome P450-14DM; Cytochrome P450-LIA1; Sterol 14-alpha demethylaseSaccharomyces cerevisiae S288C
Farnesyl pyrophosphate synthaseFPP synthase; FPS; EC 2.5.1.10; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; 2.5.1.1; Farnesyl diphosphate synthase; GeranyltranstransferaseSaccharomyces cerevisiae S288C
Cytochrome P450 61EC 1.14.19.41; C-22 sterol desaturaseSaccharomyces cerevisiae S288C
Mevalonate kinaseMK; MvK; EC 2.7.1.36; Ergosterol biosynthesis protein 12; Regulation of autonomous replication protein 1Saccharomyces cerevisiae S288C
Isopentenyl-diphosphate Delta-isomeraseEC 5.3.3.2; Isopentenyl pyrophosphate isomerase; IPP isomeraseSaccharomyces cerevisiae S288C
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1HMG-CoA reductase 1; EC 1.1.1.34Saccharomyces cerevisiae S288C
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2HMG-CoA reductase 2; EC 1.1.1.34Saccharomyces cerevisiae S288C
Acetyl-CoA acetyltransferaseEC 2.3.1.9; Acetoacetyl-CoA thiolase; Ergosterol biosynthesis protein 10Saccharomyces cerevisiae S288C
Delta(7)-sterol 5(6)-desaturaseEC 1.14.19.20; C-5 sterol desaturase; Ergosterol Delta(5,6) desaturase; Sterol-C5-desaturaseSaccharomyces cerevisiae S288C
Delta(24(24(1)))-sterol reductaseEC 1.3.1.71; C-24(28) sterol reductase; Sterol Delta(24(28))-reductaseSaccharomyces cerevisiae S288C
Sterol 24-C-methyltransferaseEC 2.1.1.41; Delta(24)-sterol C-methyltransferaseSaccharomyces cerevisiae S288C
Phosphomevalonate kinaseEC 2.7.4.2Saccharomyces cerevisiae S288C
Diphosphomevalonate decarboxylaseEC 4.1.1.33; Ergosterol biosynthesis protein 19; Mevalonate pyrophosphate decarboxylase; Mevalonate-5-diphosphate decarboxylase; MDD; MDDaseSaccharomyces cerevisiae S288C
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylatingEC 1.1.1.170Saccharomyces cerevisiae S288C

Compounds (26)

CompoundDescription
hydronium ion
Orthophosphate
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
CholesterolThe principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Coenzyme A
isopentenyl pyrophosphatesubstrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells
5-diphosphomevalonic acidRN given refers to ion(1-)
desmosterolAn intermediate in the synthesis of cholesterol.
fecosterolRN given refers to (3beta,5alpha)-isomer
24-dehydroprovitamin D3
4,4-dimethylcholesta-8,14,24-trienola meiosis activating sterol; RN given refers to (5alpha,3beta)-isomer
farnesyl pyrophosphatea sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation
geranyl pyrophosphateRN given refers to (E)-isomer
Mevalonic AcidA dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions.
lanosterolA triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. It is metabolized to CHOLESTEROL and CUCURBITACINS.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
phosphomevalonate
acetyl coenzyme aAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
creolinfrom refined coal tar oils
pyrophosphate
3,3-dimethylallyl pyrophosphateisomeric with isopentenyl pyrophosphate
zymosterola 4,14-desmethyl intermediate between LANOSTEROL and CHOLESTEROL
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