| Protein | Synonyms | Taxonomy |
|---|
| Squalene monooxygenase | EC 1.14.14.17; Squalene epoxidase; SE | Homo sapiens (human) |
| Squalene synthase | SQS; SS; EC 2.5.1.21; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase 1 | Homo sapiens (human) |
| Lanosterol synthase | EC 5.4.99.7; 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC; hOSC | Homo sapiens (human) |
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | EC 5.3.3.5; Cholestenol Delta-isomerase; Delta(8)-Delta(7) sterol isomerase; D8-D7 sterol isomerase; Emopamil-binding protein | Homo sapiens (human) |
| 7-dehydrocholesterol reductase | 7-DHC reductase; EC 1.3.1.21; Delta7-sterol reductase; Sterol Delta(7)-reductase; Sterol reductase SR-2 | Homo sapiens (human) |
| 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 | 17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; 3-keto-steroid reductase; 1.1.1.270; Dihydrotestosterone oxidoreductase; 1.1.1.210; Estradiol 17-beta-dehydrogenase 7; 1.1.1.62; Short chain dehydrogenase/reductase family 37C member 1 | Homo sapiens (human) |
| Lathosterol oxidase | EC 1.14.19.20; C-5 sterol desaturase; Delta(7)-sterol 5-desaturase; Delta(7)-sterol C5(6)-desaturase; Lathosterol 5-desaturase; Sterol-C5-desaturase | Homo sapiens (human) |
| Delta(14)-sterol reductase LBR | Delta-14-SR; EC 1.3.1.70; 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; C14SR; Integral nuclear envelope inner membrane protein; LMN2R; Lamin-B receptor; Sterol C14-reductase | Homo sapiens (human) |
| Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating | EC 1.1.1.170; Protein H105e3 | Homo sapiens (human) |
| Compound | Description |
|---|
| diphosphoric acid | |
| hydronium ion | |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| Cholesterol | The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. |
| squalene | A natural 30-carbon triterpene. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| Selenite | |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| farnesyl pyrophosphate | a sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation |
| formate | |
| 7-dehydrocholesterol | RN given refers to (3beta)-isomer; structure; main provitamin in skin that is converted by sunlight to cholecalciferol (vitamin D3) |
| 4,4-dimethylcholesta-8,14,24-trienol | a meiosis activating sterol; RN given refers to (5alpha,3beta)-isomer |
| 2,3-oxidosqualene | an oxidized derivative of SQUALENE that can fold in several ways: chair-boat-chair-boat to LANOSTEROL; chair-chair-chair-boat to dammarane; or all chair to hopane and on to cycloartenol; RN given refers to (all-Z)-isomer |
| cholesta-7,24-dien-3-ol | minor metabolite of in vitro incubation of mevalonic acid with yeast; structure; RN given refers to (3beta,5alpha)-isomer; RN for cpd without isomeric designation not avail 10/89 |
| lathosterol | RN given refers to (3beta,5alpha)-isomer |
| tellurate | |
| 4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-ol | RN given refers to (3beta,5alpha)-isomer |
| 32-oxolanosterol | found in mevalonate-treated cell cultures |
| 32-hydroxylanosterol | found in mevalonate-treated cell cultures |
| lanosterol | A triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. It is metabolized to CHOLESTEROL and CUCURBITACINS. |
| Ro 48-8071 | a cholesterol synthesis inhibitor; structure in first source |
| Flavin-Adenine Dinucleotide | A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972) |
| zymosterol | a 4,14-desmethyl intermediate between LANOSTEROL and CHOLESTEROL |
| BM 15766 | 7-dehydrocholesterol reductase antagonist |