Page last updated: 2024-10-06
superpathway of ergosterol biosynthesis
Proteins (22)
| Protein | Synonyms | Taxonomy |
|---|---|---|
| C-8 sterol isomerase | EC 5.-.-.-; Delta-8--delta-7 sterol isomerase | Saccharomyces cerevisiae S288C |
| Lanosterol synthase | EC 5.4.99.7; 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC | Saccharomyces cerevisiae S288C |
| Hydroxymethylglutaryl-CoA synthase | HMG-CoA synthase; EC 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthase | Saccharomyces cerevisiae S288C |
| 3-keto-steroid reductase | EC 1.1.1.270 | Saccharomyces cerevisiae S288C |
| Squalene synthase | SQS; SS; EC 2.5.1.21; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase | Saccharomyces cerevisiae S288C |
| Squalene monooxygenase | EC 1.14.14.17; Squalene epoxidase; SE | Saccharomyces cerevisiae S288C |
| Delta(14)-sterol reductase | EC 1.3.1.70; C-14 sterol reductase; Sterol C14-reductase | Saccharomyces cerevisiae S288C |
| Methylsterol monooxygenase | EC 1.14.18.9; C-4 methylsterol oxidase; Sterol-C4-methyl oxidase | Saccharomyces cerevisiae S288C |
| Lanosterol 14-alpha demethylase | EC 1.14.14.154; CYPLI; Cytochrome P450 51; Cytochrome P450-14DM; Cytochrome P450-LIA1; Sterol 14-alpha demethylase | Saccharomyces cerevisiae S288C |
| Farnesyl pyrophosphate synthase | FPP synthase; FPS; EC 2.5.1.10; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; 2.5.1.1; Farnesyl diphosphate synthase; Geranyltranstransferase | Saccharomyces cerevisiae S288C |
| Cytochrome P450 61 | EC 1.14.19.41; C-22 sterol desaturase | Saccharomyces cerevisiae S288C |
| Mevalonate kinase | MK; MvK; EC 2.7.1.36; Ergosterol biosynthesis protein 12; Regulation of autonomous replication protein 1 | Saccharomyces cerevisiae S288C |
| Isopentenyl-diphosphate Delta-isomerase | EC 5.3.3.2; Isopentenyl pyrophosphate isomerase; IPP isomerase | Saccharomyces cerevisiae S288C |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 | HMG-CoA reductase 1; EC 1.1.1.34 | Saccharomyces cerevisiae S288C |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 | HMG-CoA reductase 2; EC 1.1.1.34 | Saccharomyces cerevisiae S288C |
| Acetyl-CoA acetyltransferase | EC 2.3.1.9; Acetoacetyl-CoA thiolase; Ergosterol biosynthesis protein 10 | Saccharomyces cerevisiae S288C |
| Delta(7)-sterol 5(6)-desaturase | EC 1.14.19.20; C-5 sterol desaturase; Ergosterol Delta(5,6) desaturase; Sterol-C5-desaturase | Saccharomyces cerevisiae S288C |
| Delta(24(24(1)))-sterol reductase | EC 1.3.1.71; C-24(28) sterol reductase; Sterol Delta(24(28))-reductase | Saccharomyces cerevisiae S288C |
| Sterol 24-C-methyltransferase | EC 2.1.1.41; Delta(24)-sterol C-methyltransferase | Saccharomyces cerevisiae S288C |
| Phosphomevalonate kinase | EC 2.7.4.2 | Saccharomyces cerevisiae S288C |
| Diphosphomevalonate decarboxylase | EC 4.1.1.33; Ergosterol biosynthesis protein 19; Mevalonate pyrophosphate decarboxylase; Mevalonate-5-diphosphate decarboxylase; MDD; MDDase | Saccharomyces cerevisiae S288C |
| Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating | EC 1.1.1.170 | Saccharomyces cerevisiae S288C |
Compounds (37)
| Compound | Description |
|---|---|
| diphosphoric acid | |
| hydronium ion | |
| Lamisil | |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| carbon monoxide | Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed) |
| Orthophosphate | |
| ergosterol | A steroid occurring in FUNGI. Irradiation with ULTRAVIOLET RAYS results in formation of ERGOCALCIFEROL (vitamin D2). |
| Ketoconazole | Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients. |
| squalene | A natural 30-carbon triterpene. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| isopentenyl pyrophosphate | substrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells |
| farnesyl pyrophosphate | a sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation |
| geranyl diphosphate | structure in first source |
| formate | |
| Cadmium | An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING. |
| buthiobate | structure |
| ethylmaleimide | A sulfhydryl reagent that is widely used in experimental biochemical studies. |
| fecosterol | RN given refers to (3beta,5alpha)-isomer |
| 4,4-dimethylcholesta-8,14,24-trienol | a meiosis activating sterol; RN given refers to (5alpha,3beta)-isomer |
| oxophenylarsine | inhibits protein-tyrosine-phosphatase |
| Mevalonate | |
| 2,3-oxidosqualene | an oxidized derivative of SQUALENE that can fold in several ways: chair-boat-chair-boat to LANOSTEROL; chair-chair-chair-boat to dammarane; or all chair to hopane and on to cycloartenol; RN given refers to (all-Z)-isomer |
| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| arsenite | salt of arsenous acid XASO(3) |
| 4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-ol | RN given refers to (3beta,5alpha)-isomer |
| lanosterol | A triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. It is metabolized to CHOLESTEROL and CUCURBITACINS. |
| s-adenosylmethionine | Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) |
| Coenzyme A | |
| acetoacetyl CoA | |
| Acetyl Coenzyme A | Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. |
| Flavin-Adenine Dinucleotide | A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972) |
| zymosterol | a 4,14-desmethyl intermediate between LANOSTEROL and CHOLESTEROL |
| 2-bromoacetyl coenzyme A |