Page last updated: 2024-10-06

superpathway of ergosterol biosynthesis

Proteins (22)

ProteinSynonymsTaxonomy
C-8 sterol isomeraseEC 5.-.-.-; Delta-8--delta-7 sterol isomeraseSaccharomyces cerevisiae S288C
Lanosterol synthaseEC 5.4.99.7; 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSCSaccharomyces cerevisiae S288C
Hydroxymethylglutaryl-CoA synthaseHMG-CoA synthase; EC 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthaseSaccharomyces cerevisiae S288C
3-keto-steroid reductaseEC 1.1.1.270Saccharomyces cerevisiae S288C
Squalene synthaseSQS; SS; EC 2.5.1.21; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferaseSaccharomyces cerevisiae S288C
Squalene monooxygenaseEC 1.14.14.17; Squalene epoxidase; SESaccharomyces cerevisiae S288C
Delta(14)-sterol reductaseEC 1.3.1.70; C-14 sterol reductase; Sterol C14-reductaseSaccharomyces cerevisiae S288C
Methylsterol monooxygenaseEC 1.14.18.9; C-4 methylsterol oxidase; Sterol-C4-methyl oxidaseSaccharomyces cerevisiae S288C
Lanosterol 14-alpha demethylaseEC 1.14.14.154; CYPLI; Cytochrome P450 51; Cytochrome P450-14DM; Cytochrome P450-LIA1; Sterol 14-alpha demethylaseSaccharomyces cerevisiae S288C
Farnesyl pyrophosphate synthaseFPP synthase; FPS; EC 2.5.1.10; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; 2.5.1.1; Farnesyl diphosphate synthase; GeranyltranstransferaseSaccharomyces cerevisiae S288C
Cytochrome P450 61EC 1.14.19.41; C-22 sterol desaturaseSaccharomyces cerevisiae S288C
Mevalonate kinaseMK; MvK; EC 2.7.1.36; Ergosterol biosynthesis protein 12; Regulation of autonomous replication protein 1Saccharomyces cerevisiae S288C
Isopentenyl-diphosphate Delta-isomeraseEC 5.3.3.2; Isopentenyl pyrophosphate isomerase; IPP isomeraseSaccharomyces cerevisiae S288C
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1HMG-CoA reductase 1; EC 1.1.1.34Saccharomyces cerevisiae S288C
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2HMG-CoA reductase 2; EC 1.1.1.34Saccharomyces cerevisiae S288C
Acetyl-CoA acetyltransferaseEC 2.3.1.9; Acetoacetyl-CoA thiolase; Ergosterol biosynthesis protein 10Saccharomyces cerevisiae S288C
Delta(7)-sterol 5(6)-desaturaseEC 1.14.19.20; C-5 sterol desaturase; Ergosterol Delta(5,6) desaturase; Sterol-C5-desaturaseSaccharomyces cerevisiae S288C
Delta(24(24(1)))-sterol reductaseEC 1.3.1.71; C-24(28) sterol reductase; Sterol Delta(24(28))-reductaseSaccharomyces cerevisiae S288C
Sterol 24-C-methyltransferaseEC 2.1.1.41; Delta(24)-sterol C-methyltransferaseSaccharomyces cerevisiae S288C
Phosphomevalonate kinaseEC 2.7.4.2Saccharomyces cerevisiae S288C
Diphosphomevalonate decarboxylaseEC 4.1.1.33; Ergosterol biosynthesis protein 19; Mevalonate pyrophosphate decarboxylase; Mevalonate-5-diphosphate decarboxylase; MDD; MDDaseSaccharomyces cerevisiae S288C
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylatingEC 1.1.1.170Saccharomyces cerevisiae S288C

Compounds (37)

CompoundDescription
diphosphoric acid
hydronium ion
Lamisil
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
carbon monoxideCarbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
Orthophosphate
ergosterolA steroid occurring in FUNGI. Irradiation with ULTRAVIOLET RAYS results in formation of ERGOCALCIFEROL (vitamin D2).
KetoconazoleBroad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.
squaleneA natural 30-carbon triterpene.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
isopentenyl pyrophosphatesubstrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells
farnesyl pyrophosphatea sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation
geranyl diphosphatestructure in first source
formate
CadmiumAn element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.
buthiobatestructure
ethylmaleimideA sulfhydryl reagent that is widely used in experimental biochemical studies.
fecosterolRN given refers to (3beta,5alpha)-isomer
4,4-dimethylcholesta-8,14,24-trienola meiosis activating sterol; RN given refers to (5alpha,3beta)-isomer
oxophenylarsineinhibits protein-tyrosine-phosphatase
Mevalonate
2,3-oxidosqualenean oxidized derivative of SQUALENE that can fold in several ways: chair-boat-chair-boat to LANOSTEROL; chair-chair-chair-boat to dammarane; or all chair to hopane and on to cycloartenol; RN given refers to (all-Z)-isomer
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
arsenitesalt of arsenous acid XASO(3)
4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-olRN given refers to (3beta,5alpha)-isomer
lanosterolA triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. It is metabolized to CHOLESTEROL and CUCURBITACINS.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Coenzyme A
acetoacetyl CoA
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
zymosterola 4,14-desmethyl intermediate between LANOSTEROL and CHOLESTEROL
2-bromoacetyl coenzyme A