Page last updated: 2024-10-06

Ergosterol biosynthesis

Proteins (3)

ProteinSynonymsTaxonomy
3-keto-steroid reductaseEC 1.1.1.270Saccharomyces cerevisiae S288C
Methylsterol monooxygenaseEC 1.14.18.9; C-4 methylsterol oxidase; Sterol-C4-methyl oxidaseSaccharomyces cerevisiae S288C
Lanosterol 14-alpha demethylaseEC 1.14.14.154; CYPLI; Cytochrome P450 51; Cytochrome P450-14DM; Cytochrome P450-LIA1; Sterol 14-alpha demethylaseSaccharomyces cerevisiae S288C

Compounds (20)

CompoundDescription
ergosterolA steroid occurring in FUNGI. Irradiation with ULTRAVIOLET RAYS results in formation of ERGOCALCIFEROL (vitamin D2).
presqualene pyrophosphate
isopentenyl pyrophosphatesubstrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells
5-diphosphomevalonic acidRN given refers to ion(1-)
fecosterolRN given refers to (3beta,5alpha)-isomer
4,4-dimethylcholesta-8,14,24-trienola meiosis activating sterol; RN given refers to (5alpha,3beta)-isomer
3-hydroxy-3-methylglutaryl-coenzyme aRN given refers to cpd without isomeric designation
farnesyl pyrophosphatea sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation
geranyl pyrophosphateRN given refers to (E)-isomer
episterolergosterol precursor; RN given refers to (3beta,5alpha)-isomer
2,3-oxidosqualenean oxidized derivative of SQUALENE that can fold in several ways: chair-boat-chair-boat to LANOSTEROL; chair-chair-chair-boat to dammarane; or all chair to hopane and on to cycloartenol; RN given refers to (all-Z)-isomer
4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-olRN given refers to (3beta,5alpha)-isomer
32-oxolanosterolfound in mevalonate-treated cell cultures
32-hydroxylanosterolfound in mevalonate-treated cell cultures
lanosterolA triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. It is metabolized to CHOLESTEROL and CUCURBITACINS.
mevalonic acidA dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions.
phosphomevalonate
acetyl coenzyme aAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
3,3-dimethylallyl pyrophosphateisomeric with isopentenyl pyrophosphate
zymosterola 4,14-desmethyl intermediate between LANOSTEROL and CHOLESTEROL