Page last updated: 2024-10-06

Cholesterol biosynthesis

Proteins (22)

ProteinSynonymsTaxonomy
Delta(24)-sterol reductaseEC 1.3.1.72; 24-dehydrocholesterol reductase; 3-beta-hydroxysterol Delta-24-reductase; Diminuto/dwarf1 homolog; Seladin-1Homo sapiens (human)
Squalene monooxygenaseEC 1.14.14.17; Squalene epoxidase; SEHomo sapiens (human)
Delta(14)-sterol reductase TM7SF2Delta-14-SR; EC 1.3.1.70; 3-beta-hydroxysterol Delta (14)-reductase; Another new gene 1 protein; C-14 sterol reductase; C14SR; Putative sterol reductase SR-1; Sterol C14-reductase; Transmembrane 7 superfamily member 2Homo sapiens (human)
Geranylgeranyl pyrophosphate synthaseGGPP synthase; GGPPSase; EC 2.5.1.-; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; 2.5.1.1; Farnesyl diphosphate synthase; Farnesyltranstransferase; 2.5.1.29; Geranylgeranyl diphosphate synthase; Geranyltranstransferase; 2.5.1.10Homo sapiens (human)
Farnesyl pyrophosphate synthaseFPP synthase; FPS; EC 2.5.1.10; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; 2.5.1.1; Farnesyl diphosphate synthase; GeranyltranstransferaseHomo sapiens (human)
Lanosterol 14-alpha demethylaseLDM; EC 1.14.14.154; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylaseHomo sapiens (human)
Squalene synthaseSQS; SS; EC 2.5.1.21; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase 1Homo sapiens (human)
Lanosterol synthaseEC 5.4.99.7; 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC; hOSCHomo sapiens (human)
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseEC 5.3.3.5; Cholestenol Delta-isomerase; Delta(8)-Delta(7) sterol isomerase; D8-D7 sterol isomerase; Emopamil-binding proteinHomo sapiens (human)
7-dehydrocholesterol reductase7-DHC reductase; EC 1.3.1.21; Delta7-sterol reductase; Sterol Delta(7)-reductase; Sterol reductase SR-2Homo sapiens (human)
Diphosphomevalonate decarboxylaseEC 4.1.1.33; Mevalonate (diphospho)decarboxylase; MDDase; Mevalonate pyrophosphate decarboxylaseHomo sapiens (human)
Hydroxymethylglutaryl-CoA synthase, cytoplasmicHMG-CoA synthase; EC 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthaseHomo sapiens (human)
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 717-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; 3-keto-steroid reductase; 1.1.1.270; Dihydrotestosterone oxidoreductase; 1.1.1.210; Estradiol 17-beta-dehydrogenase 7; 1.1.1.62; Short chain dehydrogenase/reductase family 37C member 1Homo sapiens (human)
Lathosterol oxidaseEC 1.14.19.20; C-5 sterol desaturase; Delta(7)-sterol 5-desaturase; Delta(7)-sterol C5(6)-desaturase; Lathosterol 5-desaturase; Sterol-C5-desaturaseHomo sapiens (human)
Delta(14)-sterol reductase LBRDelta-14-SR; EC 1.3.1.70; 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; C14SR; Integral nuclear envelope inner membrane protein; LMN2R; Lamin-B receptor; Sterol C14-reductaseHomo sapiens (human)
Acetyl-CoA acetyltransferase, cytosolicEC 2.3.1.9; Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolaseHomo sapiens (human)
Mevalonate kinaseMK; EC 2.7.1.36Homo sapiens (human)
Phosphomevalonate kinasePMKase; hPMK; EC 2.7.4.2Homo sapiens (human)
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylatingEC 1.1.1.170; Protein H105e3Homo sapiens (human)
Methylsterol monooxygenase 1EC 1.14.18.9; C-4 methylsterol oxidase; Sterol-C4-methyl oxidaseHomo sapiens (human)
Phospholipid phosphatase 6EC 3.1.3.-; Phosphatidic acid phosphatase type 2 domain-containing protein 2; PPAP2 domain-containing protein 2; Presqualene diphosphate phosphataseHomo sapiens (human)
Protein ARV1hARV1Homo sapiens (human)

Compounds (40)

CompoundDescription
hydronium ion
NADH
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Orthophosphate
CholesterolThe principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
squaleneA natural 30-carbon triterpene.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
presqualene monophosphatestructure in first source
zymostenolRN given refers to (3beta,5alpha)-isomer; RN for cpd without isomeric designation not available 9/88
isopentenyl pyrophosphatesubstrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
formate
5-diphosphomevalonic acidRN given refers to ion(1-)
7-dehydrocholesterolRN given refers to (3beta)-isomer; structure; main provitamin in skin that is converted by sunlight to cholecalciferol (vitamin D3)
desmosterolAn intermediate in the synthesis of cholesterol.
24-dehydroprovitamin D3
24,25-dihydrolanosterol
4,4-dimethylcholesta-8,14,24-trienola meiosis activating sterol; RN given refers to (5alpha,3beta)-isomer
farnesyl pyrophosphatea sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation
geranyl pyrophosphateRN given refers to (E)-isomer
presqualene pyrophosphate
Mevalonate
2,3-oxidosqualenean oxidized derivative of SQUALENE that can fold in several ways: chair-boat-chair-boat to LANOSTEROL; chair-chair-chair-boat to dammarane; or all chair to hopane and on to cycloartenol; RN given refers to (all-Z)-isomer
cholesta-7,24-dien-3-olminor metabolite of in vitro incubation of mevalonic acid with yeast; structure; RN given refers to (3beta,5alpha)-isomer; RN for cpd without isomeric designation not avail 10/89
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
lathosterolRN given refers to (3beta,5alpha)-isomer
4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-olRN given refers to (3beta,5alpha)-isomer
lanosterolA triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. It is metabolized to CHOLESTEROL and CUCURBITACINS.
Coenzyme A
acetoacetyl CoA
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
creolinfrom refined coal tar oils
3,3-dimethylallyl pyrophosphateisomeric with isopentenyl pyrophosphate
zymosterola 4,14-desmethyl intermediate between LANOSTEROL and CHOLESTEROL