Equinus Contracture

Synonym
Equinus Deformity
Talipes Equinus
Equinus Contracture
Talipes Equinovalgus

Excerpt	Reference
"As equinus deformity is suspected to be one of the main factors evoking primary GR, the purpose of this study was to determine whether lengthening the calf muscles to decrease equinus would decrease coexisting GR in children with bilateral spastic CP."	( Braatz, F; Dreher, T; Heitzmann, D; Klotz, MC; Krautwurst, B; Wolf, SI, 2013)
"Equinus deformity is one of the most common gait deformities in children with cerebral palsy."	( Delp, SL; Hicks, JL; Kidziński, Ł; McGlaughlin, AS; Rajagopal, A; Schwartz, MH, 2020)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	3 (8.82)	23.3326
1990's	3 (8.82)	12.5806
2000's	16 (47.06)	18.1394
2010's	10 (29.41)	28.8240
2020's	2 (5.88)	9.53

Drug	Relationship Strength	Studies	Trials
nickel	low	1	0
phenol	low	1	0
baclofen	medium	2	1
clonidine	medium	2	1
lidocaine	low	1	0
procaine	low	1	0
tizanidine	medium	2	1
prednisone	low	1	0
mannitol	low	1	0
durapatite	low	1	0
titanium	low	1	0
calcium sulfate	low	1	0
trolamine salicylate	low	1	0
keratan sulfate	low	1	0
vendex	medium	1	1

Protein Targets (213)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
thioredoxin reductase	3	0	0	3
phosphopantetheinyl transferase	2	0	0	2
ATAD5 protein, partial	2	0	0	2
NFKB1 protein, partial	1	0	0	1
GLI family zinc finger 3	3	0	0	3
AR protein	7	0	0	7
regulator of G-protein signaling 4	3	0	0	3
67.9K protein	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	4	0	0	4
activating transcription factor 6	3	0	0	3
Bloom syndrome protein isoform 1	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
histone acetyltransferase KAT2A isoform 1	2	0	0	2
lamin isoform A-delta10	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
ATP-binding cassette sub-family C member 3	0	3	0	3
Multidrug resistance-associated protein 4	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Bile salt export pump	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	1	3
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	1	3
GABA theta subunit	2	0	0	2
Canalicular multispecific organic anion transporter 1	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
ATP-dependent phosphofructokinase	2	0	0	2
Chain A, Ferritin light chain	1	0	0	1
Chain A, Cruzipain	1	0	0	1
acetylcholinesterase	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
cytochrome P450 2D6	3	0	0	3
Beta-1 adrenergic receptor	0	0	1	1
arylsulfatase A	2	0	0	2
Alpha-1B adrenergic receptor	0	0	2	2
cytochrome P450 2D6 isoform 1	2	0	0	2
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
muscarinic acetylcholine receptor M1	3	0	0	3
Membrane primary amine oxidase	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2A adrenergic receptor	0	2	2	4
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	2	1	3
Alpha-1A adrenergic receptor	0	0	2	2
Alpha-2C adrenergic receptor	0	2	2	4
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	2	1	3
D(1B) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
5-hydroxytryptamine receptor 1B	0	2	0	2
Adenosine receptor A2b	0	0	1	1
Adenosine receptor A2a	0	1	1	2
Alpha-2B adrenergic receptor	0	0	0	1
D(4) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
Alpha-1A adrenergic receptor	0	1	1	2
Histamine H2 receptor	1	0	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Spike glycoprotein	2	0	0	2
D(2) dopamine receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Nischarin	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, Beta-lactamase	1	0	0	1
RAR-related orphan receptor gamma	4	0	0	4
GLS protein	1	0	0	1
TDP1 protein	2	0	0	2
Microtubule-associated protein tau	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
IDH1	1	0	0	1
chromobox protein homolog 1	2	0	0	2
mitogen-activated protein kinase 1	1	0	0	1
flap endonuclease 1	1	0	0	1
geminin	2	0	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
USP1 protein, partial	1	0	0	1
estrogen receptor 2 (ER beta)	2	0	0	2
glucocorticoid receptor [Homo sapiens]	3	0	0	3
retinoid X nuclear receptor alpha	3	0	0	3
estrogen-related nuclear receptor alpha	2	0	0	2
estrogen nuclear receptor alpha	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	4	0	0	4
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Cellular tumor antigen p53	2	0	0	2
TAR DNA-binding protein 43	1	0	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
retinoic acid nuclear receptor alpha variant 1	3	0	0	3
peroxisome proliferator-activated receptor delta	1	0	0	1
peroxisome proliferator activated receptor gamma	1	0	0	1
alpha-galactosidase	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
thyroid hormone receptor beta isoform 2	2	0	0	2
Polyphenol oxidase 2	0	0	0	1
Carbonic anhydrase 12	0	1	0	1
Endolysin	0	0	1	1
Carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Carbonic anhydrase 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Cannabinoid receptor 1	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 6	0	2	0	2
Adenosine receptor A1	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 9	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
pregnane X receptor	1	0	0	1
thioredoxin glutathione reductase	1	0	0	1
progesterone receptor	1	0	0	1
pregnane X nuclear receptor	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Nuclear receptor ROR-gamma	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
EWS/FLI fusion protein	1	0	0	1
peripheral myelin protein 22	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Research

Studies (34)

Protein Targets (213)

Equinus Contracture

Synonyms(4)

Research Excerpts

Overview

Research

Studies (34)

Drugs Studied (16)

Protein Targets (213)