Cockett Syndrome

A compression of ILIAC VEIN that results in a decreased flow in the vein and in the left LOWER EXTREMITY due to a vascular malformation. It may result in left leg EDEMA, pain, iliofemoral DEEP VENOUS THROMBOSIS and POSTTHROMBOTIC SYNDROME. Compression of the left common ILIAC VEIN by the right common ILIAC ARTERY against the underlying fifth LUMBAR VERTEBRA is the typical underlying malformation.

Synonym
Iliac Vein Compression Syndrome
May-Thurner Syndrome
Cockett Syndrome
Iliocaval Compression Syndrome

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	26 (81.25)	28.8240
2020's	6 (18.75)	9.53

Drug	Relationship Strength	Studies
dalteparin	low	2
aspirin	low	1
iodixanol	low	1
iohexol	low	1
propranolol	low	1
sulfur hexafluoride	low	1
gadolinium	low	1
nitinol	low	5
bilirubin	low	1
rivaroxaban	low	3
gadofosveset trisodium	low	1
warfarin	low	4
phenprocoumon	low	1

Protein Targets (198)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	1	0	0	1
thioredoxin reductase	2	0	0	2
GLS protein	1	0	0	1
AR protein	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
thyroid stimulating hormone receptor	1	0	0	1
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
EWS/FLI fusion protein	2	0	0	2
glucocorticoid receptor [Homo sapiens]	2	0	0	2
retinoic acid nuclear receptor alpha variant 1	2	0	0	2
estrogen-related nuclear receptor alpha	2	0	0	2
estrogen nuclear receptor alpha	2	0	0	2
cytochrome P450 2D6	1	0	0	1
glucocerebrosidase	1	0	0	1
peroxisome proliferator-activated receptor delta	1	0	0	1
Rac1 protein	0	0	1	1
IDH1	1	0	0	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	2	0	0	2
Bloom syndrome protein isoform 1	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
DNA polymerase kappa isoform 1	2	0	0	2
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	1	0	0	1
Prostaglandin-H2 D-isomerase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Bile salt export pump	0	5	0	5
Epidermal growth factor receptor	0	1	0	1
Carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	0	1	0	1
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, Cruzipain	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
USP1 protein, partial	1	0	0	1
Microtubule-associated protein tau	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
lamin isoform A-delta10	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
RAR-related orphan receptor gamma	2	0	0	2
Cellular tumor antigen p53	2	0	0	2
ATAD5 protein, partial	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	1	0	0	1
geminin	1	0	0	1
Spike glycoprotein	2	0	0	2
Gag-Pol polyprotein	0	1	0	1
Cytochrome P450 2D6	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
Protease	0	3	0	3
TDP1 protein	1	0	0	1
Beta-1 adrenergic receptor	0	1	1	3
arylsulfatase A	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Solute carrier family 22 member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Bile salt export pump	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Albumin	0	0	2	2
Cytochrome P450 1A2	0	1	0	1
Beta-2 adrenergic receptor	0	2	1	3
Muscarinic acetylcholine receptor M2	0	1	1	2
ATP-dependent translocase ABCB1	0	2	0	2
Beta-1 adrenergic receptor	0	2	1	3
Cytochrome P450 3A4	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2A adrenergic receptor	0	1	2	4
Adenosine receptor A3	0	1	1	2
Beta-2 adrenergic receptor	0	2	0	3
Cytochrome P450 2C8	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	1	2
Cytochrome P450 2C9	0	2	0	2
Beta-3 adrenergic receptor	0	2	1	3
D(2) dopamine receptor	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
Alpha-2B adrenergic receptor	0	0	1	2
Beta-1 adrenergic receptor	0	2	1	4
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Alpha-2C adrenergic receptor	0	1	2	4
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	1	4
Alpha-2B adrenergic receptor	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Muscarinic acetylcholine receptor M3	0	1	1	2
D(1A) dopamine receptor	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Alpha-2C adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Alpha-1D adrenergic receptor	0	1	1	2
Alpha-1D adrenergic receptor	0	0	1	2
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 2A	0	2	1	3
5-hydroxytryptamine receptor 2C	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Adenosine receptor A2a	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Type-1 angiotensin II receptor	0	1	1	2
Sodium-dependent serotonin transporter	0	2	0	2
Cholecystokinin receptor type A	0	1	1	2
Cytochrome P450 2C19	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	2
Mu-type opioid receptor	0	1	1	2
Vasopressin V1a receptor	0	1	1	2
Delta-type opioid receptor	0	1	1	2
Kappa-type opioid receptor	0	1	1	2
5-hydroxytryptamine receptor 2B	0	2	1	3
Alpha-1A adrenergic receptor	0	1	1	2
5-hydroxytryptamine receptor 6	0	2	1	3
5-hydroxytryptamine receptor 7	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
GABA theta subunit	0	1	1	2
Ataxin-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	1	2
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Chain A, Activated Factor Xa Heavy Chain	0	1	0	1
Prothrombin	0	1	0	1
Coagulation factor X	0	2	0	2
Coagulation factor XII	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Chain A, Beta-lactamase	1	0	0	1
PPM1D protein	1	0	0	1
GLI family zinc finger 3	1	0	0	1
progesterone receptor	1	0	0	1
pregnane X nuclear receptor	1	0	0	1
peroxisome proliferator activated receptor gamma	1	0	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
thyroid hormone receptor beta isoform 2	1	0	0	1
Interferon beta	1	0	0	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research

Studies (32)

Protein Targets (198)

Cockett Syndrome

Synonyms(4)

Research

Studies (32)

Drugs Studied (15)

Protein Targets (198)