valencene has been researched along with nerolidol* in 2 studies
2 other study(ies) available for valencene and nerolidol
| Article | Year |
|---|---|
Sesquiterpenes α-humulene and β-caryophyllene oxide enhance the efficacy of 5-fluorouracil and oxaliplatin in colon cancer cells.
The present study is designed to find out if sesquiterpenes, α-humulene (HUM), valencene (VAL), β-caryphyllene-oxide (CAO) and trans-nerolidol (NER), are able to improve the antiproliferative effect of classical cytostatic drugs, 5-fluorouracil (FU) and oxaliplatin (1,2-diaminocyclohexaneoxalato-platinum, OxPt), in colon cancer cell lines Caco-2 and SW-620. In addition, the possible mechanisms of sesquiterpene action are studied. The results show significant ability of HUM and especially of CAO to enhance the anti-proliferative effects of FU and OxPt in cancer cell lines Caco-2 and SW-620. On the other hand, VAL and NER are ineffective. The action of CAO could be partly based on its ability to disrupt the mitochondrial membrane potential and to activate initiator caspases, but other mechanisms are probably also involved. Based on these results, CAO seems to have the potential for combination therapy of colon cancers and deserves further study. Topics: Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Fluorouracil; Humans; Membrane Potential, Mitochondrial; Monocyclic Sesquiterpenes; Oxaliplatin; Polycyclic Sesquiterpenes; Sesquiterpenes | 2019 |
The Effects of Selected Sesquiterpenes from Myrica rubra Essential Oil on the Efficacy of Doxorubicin in Sensitive and Resistant Cancer Cell Lines.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Doxorubicin; Drug Resistance, Multiple; Drug Synergism; Drug Therapy, Combination; Humans; Monocyclic Sesquiterpenes; Myrica; Oils, Volatile; Polycyclic Sesquiterpenes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sesquiterpenes | 2017 |