Page last updated: 2024-10-15

succinoglycan

Description

succinoglycan: extracellular heteropolysaccharides from Rhizobium meliloti; polymer of octasacharide subunits, one pyruvate, one acetyl & one succinyl group per subunit [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID154586087
MeSH IDM0159180

Synonyms (4)

Synonym
succinoglycan
pyruvylglucosyl-succinylglucosyl-(glucosyl)3-acetylglucosyl-glucosyl-galactose
4,6-pyruvoyl-beta-d-glc-(1->3)-6-o-succinoyl-beta-d-glc-(1->3)-beta-d-glc-(1->6)-beta-d-glc-(1->6)-beta-d-glc-(1->4)-6-o-acetyl-beta-d-glc-(1->4)-beta-d-glc-(1->3)-alpha-d-galactose
4,6-pyruvoyl-beta-d-glucosyl-(1->3)-6-o-succinoyl-beta-d-glucosyl-(1->3)-beta-d-glucosyl-(1->6)-beta-d-glucosyl-(1->6)-beta-d-glucosyl-(1->4)-6-o-acetyl-beta-d-glucosyl-(1->4)-beta-d-glucosyl-(1->3)-alpha-d-galactose

Research Excerpts

Overview

Succinoglycan is an extracellular polysaccharide produced by most Agrobacterium strains. It is a high-molecular-weight polymer composed of repeating octasaccharide subunits.

ExcerptReference
"Succinoglycan is an industrially important exopolysaccharide biosynthesized by bacteria. "( Characterization and rheological properties analysis of the succinoglycan produced by a high-yield mutant of Rhizobium radiobacter ATCC 19358.
Chang, Z; Gao, H; Huang, D; Huang, J; Huang, L; Jia, C; Jiang, D; Jin, M; Niu, Y; Tian, J; Xie, F; Yang, L; Yang, X; Zhang, W; Zou, C, 2021
)
"Succinoglycan is an extracellular polysaccharide produced by most Agrobacterium strains."( Anti-tumor activity and immunogenicity of a succinoglycan riclin.
Ding, Z; Ge, W; Liu, J; Sun, X; Wang, L; Xu, X; Yang, Y; Zhang, J; Zhao, Y, 2021
)
"Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide subunits."( Family of glycosyl transferases needed for the synthesis of succinoglycan by Rhizobium meliloti.
Glucksmann, MA; Reuber, TL; Walker, GC, 1993
)
"Succinoglycan is a polymer of octasaccharide subunits composed of one galactose residue, seven glucose residues, and acetyl, succinyl, and pyruvyl modifications, which is synthesized on an isoprenoid lipid carrier."( Genes needed for the modification, polymerization, export, and processing of succinoglycan by Rhizobium meliloti: a model for succinoglycan biosynthesis.
Glucksmann, MA; Reuber, TL; Walker, GC, 1993
)

Bioavailability

ExcerptReference
" Upon cytotoxicity test with a human cell line, the succinoglycan dimers displayed little effect up to 1000 μM, suggesting their potential usage to improve solubility and bioavailability of poorly soluble therapeutic agents."( Solubilization of haloperidol by acyclic succinoglycan oligosaccharides.
Cho, E; Choi, JM; Choi, Y; Jung, S; Kim, H; Lee, IS, 2012
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (125)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (3.20)18.7374
1990's39 (31.20)18.2507
2000's36 (28.80)29.6817
2010's32 (25.60)24.3611
2020's14 (11.20)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews5 (3.91%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other123 (96.09%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]