Page last updated: 2024-10-06

superpathway of nicotinate degradation

Proteins (12)

ProteinSynonymsTaxonomy
Nicotinate dehydrogenase medium molybdopterin subunitNDH; EC 1.17.1.5; Nicotinic acid hydroxylase medium molybdopterin subunit; NAHEubacterium barkeri
Nicotinate dehydrogenase large molybdopterin subunitNDH; EC 1.17.1.5; Nicotinic acid hydroxylase large molybdopterin subunit; NAHEubacterium barkeri
Nicotinate dehydrogenase small FeS subunitNDH; EC 1.17.1.5; Nicotinic acid hydroxylase small FeS subunit; NAHEubacterium barkeri
Nicotinate dehydrogenase FAD-subunitNDH; EC 1.17.1.5; Nicotinic acid hydroxylase FAD-subunit; NAHEubacterium barkeri
2,3-dimethylmalate dehydratase small subunitEC 4.2.1.85Eubacterium barkeri
2,3-dimethylmalate dehydratase large subunitEC 4.2.1.85Eubacterium barkeri
3-methylitaconate isomeraseEC 5.3.3.6; (R)-3-methylitaconate isomerase; 3-methylitaconate delta-isomeraseEubacterium barkeri
2-methyleneglutarate mutaseEC 5.4.99.4; Alpha-methyleneglutarate mutaseEubacterium barkeri
2,3-dimethylmalate lyaseEC 4.1.3.32Eubacterium barkeri
EnamidaseEC 3.5.2.18Eubacterium barkeri
2-(hydroxymethyl)glutarate dehydrogenaseEC 1.1.1.291Eubacterium barkeri
6-hydroxynicotinate reductaseEC 1.3.7.1Eubacterium barkeri

Compounds (38)

CompoundDescription
hydronium ion
Succinate
MolybdenumA metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.
NADH
Ammonium
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
serum p-componentclose relation to C reactive protein; may be ovosomucoid
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Glutathione DisulfideA GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.
fumaratesCompounds based on fumaric acid.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
Nico-400
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
iodoacetamideAn alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate.
cobamamide
propionic anhydride
cyanatesOrganic salts of cyanic acid containing the -OCN radical.
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
1,10-phenanthrolineRN given refers to parent cpd; inhibits Zn-dependent metalloproteinases
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
formate
ethylmaleimideA sulfhydryl reagent that is widely used in experimental biochemical studies.
Edetic AcidA chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.
maleate
itaconate
4-ChloromercuribenzenesulfonateA cytotoxic sulfhydryl reagent that inhibits several subcellular metabolic systems and is used as a tool in cellular physiology.
glutaconic acidRN given refers to parent cpd without isomeric designation; structure
2,5-dihydroxypyridine
2,2'-dipyridylA reagent used for the determination of iron.
1,4,5,6-tetrahydro-6-oxonicotinate
alpha-methylene glutarate
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
QuinacrineAn acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.