pradimicin a profile

pradimicin A: from actinomycete strain No. P157-2; has inhibitory effect against HIV in vitro; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

pradimicin A : A member of the class of pradimicins that is isolated from the cultured broth of Actinomadura hibisca No. P157-2 (ATCC 53557). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	5479145
CHEMBL ID	1673205
CHEBI ID	8349
SCHEMBL ID	499208
MeSH ID	M0162064

Synonym
(2r)-2-[[(5s,6s)-1,6,9,14-tetrahydroxy-5-[(2s,3r,4s,5s,6r)-3-hydroxy-6-methyl-5-(methylamino)-4-[(2s,3r,4s,5r)-3,4,5-trihydroxytetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-11-methoxy-3-methyl-8,13-dioxo-5,6-dihydrobenzo[a]tetracene-2-carbonyl]amino]p
prm-a
d-alanine, n-[[(5s,6s)-5-[[4,6-dideoxy-4-(methylamino)-3-o-.beta.-d-xylopyranosyl-.beta.-d-galactopyranosyl]oxy]-5,6,8,13-tetrahydro-1,6,9,14-tetrahydroxy-11-methoxy-3-methyl-8,13-dioxobenzo[a]naphthacen-2-yl]carbonyl]-
pradimicin a & glycogen
bmy 28567
pradimicin a & pectin
pradimicin a
117704-65-1
(2r)-2-[[(5s,6s)-1,6,9,14-tetrahydroxy-5-[(2s,3r,4s,5s,6r)-3-hydroxy-6-methyl-5-(methylamino)-4-[(2s,3r,4s,5r)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-11-methoxy-3-methyl-8,13-dioxo-5,6-dihydrobenzo[a]tetracene-2-carbonyl]amino]propanoic acid
CHEMBL1673205
pradimicin-a
chebi:8349 ,
SCHEMBL499208
(2r)-2-({[(5s,6s)-1,6,9,14-tetrahydroxy-5-{[(2s,3r,4s,5s,6r)-3-hydroxy-6-methyl-5-(methylamino)-4-{[(2s,3r,4s,5r)-3,4,5-trihydroxytetrahydro-2h-pyran-2-yl]oxy}tetrahydro-2h-pyran-2-yl]oxy}-11-methoxy-3-methyl-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracen
Q27108053
(r)-2-((5s,6s)-1,6,9,14-tetrahydroxy-5-(((2s,3r,4s,5s,6r)-3-hydroxy-6-methyl-5-(methylamino)-4-(((2s,3r,4s,5r)-3,4,5-trihydroxytetrahydro-2h-pyran-2-yl)oxy)tetrahydro-2h-pyran-2-yl)oxy)-11-methoxy-3-methyl-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracene-2
CS-0169773
HY-132191
DTXSID201043968
GLXC-25326

Class	Description
disaccharide derivative	A carbohydrate derivative that is formally obtained from a disaccharide.
polyphenol	Members of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group.
aromatic ether	Any ether in which the oxygen is attached to at least one aryl substituent.
secondary alcohol	A secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it.
pradimicin	A class of antifungal bacterial metabolites whose structure is characterised by an aglycone of dihydrobenzonaphthacequinone with substitutions by a D-amino acid and a hexose sugar moiety.
L-alanine derivative	A proteinogenic amino acid derivative resulting from reaction of L-alanine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-alanine by a heteroatom.
p-quinones	A quinone in which the two oxo groups of the quinone are located para to each other on the 6-membered quinonoid ring.
carboxylic acid	A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (157)

Assay ID	Title	Year	Journal	Article
AID572308	Cytotoxicity against human HeLa cells after 3 to 4 days	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572304	Ratio of EC90 to EC50 for X4 tropic HIV-2 BV-5061 W infected in human PBMC	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1264925	Cytotoxicity against human CEM cells assessed as cell count after 3 days	2015	European journal of medicinal chemistry, Dec-01, Volume: 106	Tryptophan dendrimers that inhibit HIV replication, prevent virus entry and bind to the HIV envelope glycoproteins gp120 and gp41.
AID572316	Antiviral activity against HIV-1 3B infected in human HUT78 cells assessed as prevention of syncytium formation between persistently HIV-1 3B-infected HUT-78 cells and uninfected SupT1 cells after 3 to 4 days by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575892	Immunostimulatory activity against human PBMC assessed as PDGF production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572346	Immunostimulatory activity against human PBMC assessed as IL-13 production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575927	Immunostimulatory activity against human PBMC assessed as suppression of IL-2 production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572326	Binding affinity to HIV-1 3B gp120 assessed as dissociation rate constant after 6 mins by SPR analysis in presence of 10 mM CaCl2	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575910	Immunostimulatory activity against human PBMC assessed as GM-CSF production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID571633	Cytotoxicity against human MT4 cells after 7 days by trypan blue staining	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572319	Antiviral activity against X4 tropic HIV-1 3B infected in human Raji cells expressing DC-SIGN gene assessed as prevention of syncytium formation between persistently HIV-1 3B-infected Raji cells and uninfected human C8166 cells after 36 to 42 hrs by micro	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575932	Immunostimulatory activity against human PBMC assessed as suppression of IL-13 production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575919	Immunostimulatory activity against human PBMC assessed as suppression of IL-2 production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572306	Cytotoxicity against human C8166 cells after 3 to 4 days	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572351	Immunostimulatory activity against human PBMC assessed as GM-CSF production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1528484	Selectivity index, ratio of CC50 for human MT4 cells to EC50 for HIV-2 ROD infected in human MT4 cells	2020	Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1	Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors.
AID572336	Antiviral activity against HIV-1 3B harboring wild type gp120 infected in human CEM cells assessed as inhibition of virus-induced cytopathicity after 3 to 4 days by microscopic analysis	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID571629	Antiviral activity against SIV mac251 infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity after 7 days by trypan blue staining	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575930	Immunostimulatory activity against human PBMC assessed as suppression of IL-4 production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID643647	Binding affinity to [13C6]-methyl alpha-D-mannopyranoside by 2-DDARR in presence of Ca2+ relative to TMS	2012	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2	Solid-state NMR analysis of calcium and d-mannose binding of BMY-28864, a water-soluble analogue of pradimicin A.
AID571627	Antiviral activity against HIV-1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity after 7 days by trypan blue staining	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID612570	Antiviral activity against HIV2 ROD infected in human CEM cells assessed as inhibition of virus-induced cytopathicity after 4 days	2011	Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15	Targeting HIV entry through interaction with envelope glycoprotein 120 (gp120): synthesis and antiviral evaluation of 1,3,5-triazines with aromatic amino acids.
AID575894	Immunostimulatory activity against human PBMC assessed as TNF-alpha production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575912	Immunostimulatory activity against human PBMC assessed as MCP-1 production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID571637	Antiviral activity against X4 tropic HIV-1 clade D isolate UG270 infected in human PBMC assessed as inhibition of viral replication after 3 days by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575921	Immunostimulatory activity against human PBMC assessed as suppression of IL-9 production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572310	Cytotoxicity against human Caco2 cells after 3 to 4 days	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575943	Aqueous solubility of the compound at physiological pH	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1237057	Binding affinity to D-Glucose assessed as molar ratio of sugar to compound in aggregate at pH 4.5 by co-precipitation method in presence of Ca2+	2015	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15	Pradimicin A, a D-mannose-binding antibiotic, binds pyranosides of L-fucose and L-galactose in a calcium-sensitive manner.
AID572325	Binding affinity to HIV-1 3B gp120 assessed as association rate constant after 6 mins by SPR analysis in presence of 10 mM CaCl2	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID571631	Antiviral activity against HIV-1 3B cells infected in human PBMC cells assessed as inhibition of virus-induced cytopathicity after 3 to 4 days by microscopic analysis	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572321	Antiviral activity against SIV mac251 infected in human Raji cells expressing DC-SIGN gene assessed as inhibition of virus capture by Raji cells after 60 mins by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572295	Ratio of EC90 to EC50 for R5 tropic HIV-1 clade B isolate US2 infected in human PBMC	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1237079	Binding affinity to Alpha-D-Mannose-OMe assessed as molar ratio of sugar to compound in aggregate at pH 4.5 by co-precipitation method in presence of Ca2+	2015	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15	Pradimicin A, a D-mannose-binding antibiotic, binds pyranosides of L-fucose and L-galactose in a calcium-sensitive manner.
AID1883317	Cytotoxicity against human MT4 cells assessed as cell viability measured after 5 days by MTS assay	2022	European journal of medicinal chemistry, Jul-05, Volume: 237	Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors.
AID572318	Antiviral activity against R5 tropic HIV-1 Bal infected in human Raji cells expressing DC-SIGN gene assessed as inhibition of virus capture by Raji cells after 60 mins by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575900	Immunostimulatory activity against human PBMC assessed as IL-6 production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575916	Immunostimulatory activity against human PBMC assessed as RANTES production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1197622	Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID571628	Antiviral activity against HIV-2 ROD infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity after 7 days by trypan blue staining	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575914	Immunostimulatory activity against human PBMC assessed as MIP-1beta production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572296	Ratio of EC90 to EC50 for R5 tropic HIV-1 clade C isolate ETH2220 infected in human PBMC	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572292	Antiviral activity against X4 tropic HIV-2 BV-5061 W infected in human PBMC assessed as inhibition of viral replication after 3 days by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1812643	Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 5 days by MTS/PES assay
AID572294	Ratio of EC90 to EC50 for R5 tropic HIV-1 clade A isolate UG273 infected in human PBMC	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572293	Cytotoxicity against human PBMC after 7 days by trypan blue staining	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1812641	Anti-HIV activity against HIV-1 NL4.3 infected in human MT4 cells assessed as reduction in virus-indued cytopathic effect preincubated with cells for 30 mins followed by viral infection and measured after 5 days by MTS assay
AID575935	Immunostimulatory activity against human PBMC assessed as suppression of G-CSF production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1883322	Selectivity index, ratio of CC50 for human MT4 cells to EC50 for antiviral activity against HIV-1 NL4.3	2022	European journal of medicinal chemistry, Jul-05, Volume: 237	Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors.
AID1197621	Antiviral activity against HIV2 ROD infected in human CEM cells assessed as reduction in virus-induced cytopathicity after 4 to 5 days by microscopy based syncytium cell formation assay	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID575902	Immunostimulatory activity against human PBMC assessed as IL-9 production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575897	Immunostimulatory activity against human PBMC assessed as IL-1ra production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575898	Immunostimulatory activity against human PBMC assessed as IL-2 production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572354	Immunostimulatory activity against human PBMC assessed as MIP-1alpha production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572343	Immunostimulatory activity against human PBMC assessed as IL-9 production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575926	Immunostimulatory activity against human PBMC assessed as suppression of PDGF production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1264924	Antiviral activity against HIV2 ROD infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis	2015	European journal of medicinal chemistry, Dec-01, Volume: 106	Tryptophan dendrimers that inhibit HIV replication, prevent virus entry and bind to the HIV envelope glycoproteins gp120 and gp41.
AID572342	Immunostimulatory activity against human PBMC assessed as IL-8 production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1883319	Antiviral activity against HIV2 ROD infected in human MT4 cells assessed as protection against virus induced cytopatheic effect measured after 5 days by MTS assay	2022	European journal of medicinal chemistry, Jul-05, Volume: 237	Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors.
AID572317	Antiviral activity against X4 tropic HIV-1 3B infected in human Raji cells expressing DC-SIGN gene assessed as inhibition of virus capture by Raji cells after 60 mins by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575922	Immunostimulatory activity against human PBMC assessed as suppression of IL-13 production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572348	Immunostimulatory activity against human PBMC assessed as eotoxin production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572311	Cytotoxicity against human U87 cells after 3 to 4 days	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572288	Antiviral activity against R5 tropic HIV-1 clade G isolate BCF-DIOUM infected in human PBMC assessed as inhibition of viral replication after 3 days by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID571632	Cytotoxicity against human CEM cells after 7 days by trypan blue staining	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1717662	Antifungal activity against Candida albicans A9540 infected in iv dosed ICR mouse assessed as protection against fungus-induced lethal infection dosed once immediately following fungal challenge and measured on day 20 post infection	2020	Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21	Recent Progress in the Discovery of Antifungal Agents Targeting the Cell Wall.
AID575918	Immunostimulatory activity against human PBMC assessed as VEGF production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575915	Immunostimulatory activity against human PBMC assessed as PDGF production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572330	Binding affinity to HIV-1 HXB2 gp41 after 6 mins by SPR analysis in presence of 10 mM CaCl2	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575936	Immunostimulatory activity against human PBMC assessed as suppression of PDGF production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575903	Immunostimulatory activity against human PBMC assessed as IL-10 production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1270885	Antiviral activity against HIV1 3B infected in human CD4+ T-lymphocyte CEM cells assessed as inhibition of virus-induced cytopathicity after 4 to 5 days by microscopic analysis	2015	European journal of medicinal chemistry, Dec-01, Volume: 106	Anti-HIV-1 activity of a tripodal receptor that recognizes mannose oligomers.
AID575901	Immunostimulatory activity against human PBMC assessed as IL-8 production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID571634	Antiviral activity against R5 tropic HIV-1 clade A isolate UG273 infected in human PBMC assessed as inhibition of viral replication after 3 days by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID571625	Antiviral activity against HIV-1 3B infected in human CEM cells assessed as inhibition of virus-induced cytopathicity after 3 to 4 days by microscopic analysis	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID571630	Antiviral activity against HIV-1 3B infected in human C8166 cells assessed as inhibition of virus-induced cytopathicity after 3 to 4 days by microscopic analysis	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572355	Immunostimulatory activity against human PBMC assessed as MIP-1beta production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572345	Immunostimulatory activity against human PBMC assessed as IL-12 production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572299	Ratio of EC90 to EC50 for R5 tropic HIV-1 clade F isolate BZ163 infected in human PBMC	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1528482	Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 5 days by MTS/PES assay	2020	Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1	Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors.
AID1528481	Antiviral activity against HIV-2 ROD infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect preincubated for 30 mins followed by viral infection and measured after 5 days by MTS assay	2020	Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1	Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors.
AID572289	Antiviral activity against X4 tropic HIV-1 group O isolate BCF06 infected in human PBMC assessed as inhibition of viral replication after 3 days by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1528483	Selectivity index, ratio of CC50 for human MT4 cells to EC50 for HIV1 NL4.3 infected in human MT4 cells	2020	Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1	Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors.
AID572314	Cytotoxicity against human PBMC cells at 50 uM after 7 days	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575904	Immunostimulatory activity against human PBMC assessed as IL-12 production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572302	Ratio of EC90 to EC50 for X4 tropic HIV-1 3B infected in human PBMC	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575931	Immunostimulatory activity against human PBMC assessed as suppression of IL-9 production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575917	Immunostimulatory activity against human PBMC assessed as TNF-alpha production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572298	Ratio of EC90 to EC50 for R5 tropic HIV-1 clade A/E isolate ID12 infected in human PBMC	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572322	Antiviral activity against SIV mac251 infected in human Raji cells expressing DC-SIGN gene assessed as prevention of syncytium formation between persistently HIV-1 3B-infected Raji cells and uninfected human C8166 cells after 60 mins by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575929	Immunostimulatory activity against human PBMC assessed as suppression of RANTES production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572291	Antiviral activity against X4 tropic HIV-1 Bal infected in human PBMC assessed as inhibition of viral replication after 3 days by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575907	Immunostimulatory activity against human PBMC assessed as eotoxin production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572300	Ratio of EC90 to EC50 for R5 tropic HIV-1 clade G isolate BCF-DIOUM infected in human PBMC	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572307	Cytotoxicity against human Molt4 cells after 3 to 4 days	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575928	Immunostimulatory activity against human PBMC assessed as suppression of IL1-beta production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572334	Antiviral activity against compound pretreated HIV-1 3B isolate 42 harboring gp120 mutant infected in human CEM cells assessed as inhibition of virus-induced cytopathicity after 3 to 4 days by microscopic analysis	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572353	Immunostimulatory activity against human PBMC assessed as MCP-1 production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575942	Aqueous solubility of the compound	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID571626	Antiviral activity against HIV-2 ROD infected in human CEM cells assessed as inhibition of virus-induced cytopathicity after 3 to 4 days by microscopic analysis	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572324	Binding affinity to HIV-1 HXB2 gp41 after 6 mins by SPR analysis	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID643644	Solubility of the compound in phosphate buffered saline at pH 7.4	2012	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2	Solid-state NMR analysis of calcium and d-mannose binding of BMY-28864, a water-soluble analogue of pradimicin A.
AID612571	Antiviral activity against HIV1 3B infected in human CEM cells assessed as inhibition of virus-induced cytopathicity after 4 days	2011	Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15	Targeting HIV entry through interaction with envelope glycoprotein 120 (gp120): synthesis and antiviral evaluation of 1,3,5-triazines with aromatic amino acids.
AID572340	Immunostimulatory activity against human PBMC assessed as IL-4 production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572329	Binding affinity to HIV-1 3B gp120 after 6 mins by SPR analysis in presence of 10 mM CaCl2	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572337	Immunostimulatory activity against human PBMC assessed as IL1-beta production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID571638	Antiviral activity against R5 tropic HIV-1 clade A/E isolate ID12 infected in human PBMC assessed as inhibition of viral replication after 3 days by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572303	Ratio of EC90 to EC50 for X4 tropic HIV-1 Bal infected in human PBMC	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1270887	Cytotoxicity against human CD4+ T-lymphocyte CEM cells	2015	European journal of medicinal chemistry, Dec-01, Volume: 106	Anti-HIV-1 activity of a tripodal receptor that recognizes mannose oligomers.
AID575940	Antiviral activity against HIV-1 3B infected in human HUT78 cells assessed as prevention of syncytium formation between persistently HIV-1 3B-infected HUT-78 cells and uninfected SupT1 cells compound preexposed to high temperature after 3 to 4 days by ELI	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572297	Ratio of EC90 to EC50 for X4 tropic HIV-1 clade D isolate UG270 infected in human PBMC	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575908	Immunostimulatory activity against human PBMC assessed as FGF production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572323	Binding affinity to HIV-1 3B gp120 after 6 mins by SPR analysis	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572328	Binding affinity to HIV-1 HXB2 gp41 assessed as dissociation rate constant after 6 mins by SPR analysis in presence of 10 mM CaCl2	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572350	Immunostimulatory activity against human PBMC assessed as G-CSF production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575905	Immunostimulatory activity against human PBMC assessed as IL-13 production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572352	Immunostimulatory activity against human PBMC assessed as IP-10 production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575909	Immunostimulatory activity against human PBMC assessed as G-CSF production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575899	Immunostimulatory activity against human PBMC assessed as IL-4 production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572320	Antiviral activity against compound pretreated X4 tropic HIV-1 3B infected in human Raji cells expressing DC-SIGN gene assessed as prevention of syncytium formation between persistently HIV-1 3B-infected Raji cells and uninfected human C8166 cells after 4	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575906	Immunostimulatory activity against human PBMC assessed as IL-15 production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1883318	Antiviral activity against HIV1 NL4-3 infected in human MT4 cells assessed as protection against virus induced cytopatheic effect measured after 5 days by MTS assay	2022	European journal of medicinal chemistry, Jul-05, Volume: 237	Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors.
AID572305	Cytotoxicity against mouse L1210 cells after 3 to 4 days	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1812642	Anti-HIV activity against HIV-2 ROD infected in human MT4 cells assessed as reduction in virus-indued cytopathic effect preincubated with cells for 30 mins followed by viral infection and measured after 5 days by MTS assay
AID575925	Immunostimulatory activity against human PBMC assessed as suppression of G-CSF production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575893	Immunostimulatory activity against human PBMC assessed as RANTES production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575924	Immunostimulatory activity against human PBMC assessed as suppression of eotoxin production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572339	Immunostimulatory activity against human PBMC assessed as IL-2 production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572315	Antiviral activity against SIV mac251 infected in human HUT78 cells assessed as prevention of syncytium formation between persistently SIV mac251-infected HUT-78 cells and uninfected CEM cells after 3 to 4 days by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575920	Immunostimulatory activity against human PBMC assessed as suppression of IL-4 production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575923	Immunostimulatory activity against human PBMC assessed as suppression of IL-15 production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572344	Immunostimulatory activity against human PBMC assessed as IL-10 production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575911	Immunostimulatory activity against human PBMC assessed as IP-10 production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1264923	Antiviral activity against HIV1 3B infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis	2015	European journal of medicinal chemistry, Dec-01, Volume: 106	Tryptophan dendrimers that inhibit HIV replication, prevent virus entry and bind to the HIV envelope glycoproteins gp120 and gp41.
AID612547	Cytotoxicity against human CEM cells after 4 days by by Coulter counter analysis	2011	Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15	Targeting HIV entry through interaction with envelope glycoprotein 120 (gp120): synthesis and antiviral evaluation of 1,3,5-triazines with aromatic amino acids.
AID575913	Immunostimulatory activity against human PBMC assessed as MIP-1alpha production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572341	Immunostimulatory activity against human PBMC assessed as IL-6 production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1197620	Antiviral activity against HIV1 3B infected in human CEM cells assessed as reduction in virus-induced cytopathicity after 4 to 5 days by microscopy based syncytium cell formation assay	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID572309	Cytotoxicity against human thymidine kinase-negative OST cells after 3 to 4 days	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572349	Immunostimulatory activity against human PBMC assessed as FGF production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572347	Immunostimulatory activity against human PBMC assessed as IL-15 production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID1528480	Antiviral activity against HIV1 NL4.3 infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect preincubated for 30 mins followed by viral infection and measured after 5 days by MTS assay	2020	Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1	Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors.
AID575895	Immunostimulatory activity against human PBMC assessed as VEGF production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572301	Ratio of EC90 to EC50 for X4 tropic HIV-1 group O isolate BCF06 infected in human PBMC	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572327	Binding affinity to HIV-1 HXB2 gp41 assessed as association rate constant after 6 mins by SPR analysis in presence of 10 mM CaCl2	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575933	Immunostimulatory activity against human PBMC assessed as suppression of IL-15 production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575939	Antiviral activity against HIV-1 3B infected in human HUT78 cells assessed as prevention of syncytium formation between persistently HIV-1 3B-infected HUT-78 cells and uninfected SupT1 cells compound preexposed at pH 4 after 3 to 4 days by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572290	Antiviral activity against X4 tropic HIV-1 3B infected in human PBMC assessed as inhibition of viral replication after 3 days by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572338	Immunostimulatory activity against human PBMC assessed as IL-1ra production at 21 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID572312	Cytotoxicity against human PBMC cells after 3 to 4 days	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575941	Binding affinity to HIV-1 3B gp120 after 6 mins by SPR analysis at pH 4	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575896	Immunostimulatory activity against human PBMC assessed as IL1-beta production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID571635	Antiviral activity against R5 tropic HIV-1 clade B isolate US2 infected in human PBMC assessed as inhibition of viral replication after 3 days by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID571636	Antiviral activity against R5 tropic HIV-1 clade C isolate ETH2220 infected in human PBMC assessed as inhibition of viral replication after 3 days by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID643646	Binding affinity to methyl alpha-D-mannopyranoside at -135 ppm by Solid-state CP/MAS 113Cd NMR spectroscopy	2012	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2	Solid-state NMR analysis of calcium and d-mannose binding of BMY-28864, a water-soluble analogue of pradimicin A.
AID572287	Antiviral activity against R5 tropic HIV-1 clade F isolate BZ163 infected in human PBMC assessed as inhibition of viral replication after 3 days by ELISA	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
AID575934	Immunostimulatory activity against human PBMC assessed as suppression of eotoxin production at 22 uM after 72 hrs	2010	Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4	Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (4.84)	18.7374
1990's	25 (40.32)	18.2507
2000's	11 (17.74)	29.6817
2010's	17 (27.42)	24.3611
2020's	6 (9.68)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	4 (6.45%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	58 (93.55%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
adenine [no description available]	3.08	1	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
gallic acid gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.	2.11	1	trihydroxybenzoic acid	antineoplastic agent; antioxidant; apoptosis inducer; astringent; cyclooxygenase 2 inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; geroprotector; human xenobiotic metabolite; plant metabolite
dapi DAPI: RN given refers to parent cpd.	2.01	1	indoles	fluorochrome
streptonigrin [no description available]	3.08	1	pyridines; quinolone	antimicrobial agent; antineoplastic agent
alanine Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.	2.38	2	alanine zwitterion; alanine; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid	EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; fundamental metabolite
galactose galactopyranose : The pyranose form of galactose.	7.11	1	D-galactose; galactopyranose	Escherichia coli metabolite; mouse metabolite
thiazoles [no description available]	2.03	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
ethyl gallate ethyl gallate: used with osmium in procedure for mapping neuronal pathways. ethyl gallate : A gallate ester obtained by the formal condensation of gallic acid with ethanol.	2.11	1	gallate ester	plant metabolite
n-butyl gallate [no description available]	2.11	1
lauryl gallate [no description available]	2.11	1	gallate ester
glycyrrhizic acid glycyrrhizinic acid : A triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.	1.98	1	enone; glucosiduronic acid; pentacyclic triterpenoid; tricarboxylic acid; triterpenoid saponin	EC 3.4.21.5 (thrombin) inhibitor; plant metabolite
fucose Fucose: A six-member ring deoxysugar with the chemical formula C6H12O5. It lacks a hydroxyl group on the carbon at position 6 of the molecule.. L-fucopyranose : The pyranose form of L-fucose.. fucose : Any deoxygalactose that is deoxygenated at the 6-position.	7.11	1	fucopyranose; L-fucose	Escherichia coli metabolite; mouse metabolite
mannose mannopyranose : The pyranose form of mannose.	5.54	12	D-aldohexose; D-mannose; mannopyranose	metabolite
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	2	1	dihydrogen
galactose aldohexose : A hexose with a (potential) aldehyde group at one end.	1.98	1
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	1.98	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
zidovudine Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.	2.43	2	azide; pyrimidine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor
octyl gallate [no description available]	2.11	1	gallate ester	food antioxidant; hypoglycemic agent; plant metabolite
thiazolyl blue thiazolyl blue: RN & II refers to bromide. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide : The bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.	2.03	1	organic bromide salt	colorimetric reagent; dye
pirodavir pirodavir: antipicornavirus agent; structure given in first source	2.72	2
oxetanocin a oxetanocin: from Bacillus megaterium NK84-0218; structure given in first source. oxetanocin A : A nucleoside analogue found in Bacillus megaterium in which an adenine moiety is attached to position 2 of a of an oxetane ring which is substituted at positions 3 and 4 by hydroxymethyl groups.	3.08	1	diol; nucleoside analogue; oxetanes; primary alcohol	anti-HIV agent; antibacterial agent; bacterial metabolite
pradimicin fa 2 pradimicin FA 2: structure given in first source; des-N-methyl analog of pradimicin FA-1; isolated from Actinomadura hibisca	2.38	2
anidulafungin Anidulafungin: Echinocandin antifungal agent that is used in the treatment of CANDIDEMIA and CANDIDIASIS.. anidulafungin : A semisynthetic echinocandin anti-fungal drug. It is active against Aspergillus and Candida species and is used for the treatment of invasive candidiasis.	3.35	1	antibiotic antifungal drug; azamacrocycle; echinocandin; heterodetic cyclic peptide; semisynthetic derivative
nikkomycin nikkomycin Z : A uridine-based nucleoside-peptide antibiotic which inhibits fungal chitin biosynthesis by inhibiting chitin synthase.	3.35	1	nikkomycin	antifungal agent
tenofovir tenofovir (anhydrous) : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.	2.52	2	nucleoside analogue; phosphonic acids	antiviral drug; drug metabolite; HIV-1 reverse transcriptase inhibitor
micafungin Micafungin: A cyclic lipo-hexapeptide echinocandin antifungal agent that is used for the treatment and prevention of CANDIDIASIS.. micafungin : A cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall. It is used as the sodium salt for the treatment of invasive candidiasis, and of aspergillosis in patients who are intolerant of other therapy.	3.35	1	antibiotic antifungal drug; echinocandin	antiinfective agent
pentyl gallate pentyl gallate: food and pharmaceutical antioxidant with ability of electron-donating; structure in first source	2.11	1
glycosides [no description available]	3.55	2
cancidas [no description available]	3.35	1
telaprevir [no description available]	2.11	1	cyclopentapyrrole; cyclopropanes; oligopeptide; pyrazines	antiviral drug; hepatitis C protease inhibitor; peptidomimetic
n,n-dimethylpradimicin fa-2 N,N-dimethylpradimicin FA-2: pradimicin A derivative; structure given in first source	5.31	10
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	3.54	2	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
benanomicin b benanomicin B: from Actinomycete sp. MH193-16F4; structure given in first source. pradimicin C : A member of the class of pradimicins that is isolated from the cultured broth of Actinomadura hibisca No. P157-2 (ATCC 53557).	3.24	6	aromatic ether; disaccharide derivative; L-alanine derivative; polyketide; polyphenol; pradimicin; secondary alcohol
benanomicin a benanomicin A: from Actinomycete sp. MH193-16F4; structure given in first source	3.52	2
pradimicin b pradimicin B: from actinomycete strain No. P157-2; structure given in first source. pradimicin B : A member of the class of prodimicins that is isolated from the cultured broth of Actinomadura hibisca No. P157-2 (ATCC 53557).	3.1	5	aromatic ether; L-alanine derivative; monosaccharide derivative; polyketide; polyphenol; pradimicin; secondary alcohol
monorden monorden: inhibits HSP90 Heat-Shock Proteins, DNA topoisomerase VI and human Topoisomerase II	3.35	1	cyclic ketone; enone; epoxide; macrolide antibiotic; monochlorobenzenes; phenols	antifungal agent; metabolite; tyrosine kinase inhibitor
n(3)-(4-methoxyfumaroyl)-2,3-diaminopropionic acid N(3)-(4-methoxyfumaroyl)-2,3-diaminopropionic acid: inhibits glucosamine synthetase in E coli; structure given in first source; RN given refers to (S-(E)-isomer). N(3)-(4-methoxyfumaroyl)-2,3-diaminopropionic acid : A monocarboxylic acid amide obtained by the formal condensation of the terminal amino group of 3-amino-L-alanine with the carboxy group of (2E)-4-methoxy-4-oxobut-2-enoic acid.	3.35	1	enoate ester; methyl ester; monocarboxylic acid amide	metabolite
3'-hydroxybenanomicin a 3'-hydroxybenanomicin A: structure given in first source; derived from PRM FA-2	3.53	2
yw 3548 YW 3548: inhibits glycosylphosphatidylinositol synthesis; structure in first source. YW3548 : A terpene lactone that is obtained from Codinea simplex and acts as an inhibitor of glycerophosphoinositol biosynthesis.	3.35	1	olefinic compound; terpene lactone; tertiary alcohol	fungal metabolite; glycerophosphoinositol synthesis inhibitor
pradimicin s pradimicin S: structure given in first source; isolated from Actinomadura spinosa; the 3'-O-(3''-O-sulfo-beta-D-glucopyranosyl) analog of pradimicin A	2.73	3
3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine APX001A: has antifungal activity; structure in first source	3.35	1
mannans [no description available]	2.67	3
enfumafungin enfumafungin: from endophytic Hormonema species; structure in first source. enfumafungin : A triterpene glycoside and hemiacetal isolated from a fermentation of Hormonema sp. and which specifically inhibits glucan synthesis in fungal cells.	3.35	1	lactol; monosaccharide derivative; triterpenoid saponin	antifungal agent
glycolipids [no description available]	7.04	1
dolutegravir [no description available]	2.11	1	difluorobenzene; monocarboxylic acid amide; organic heterotricyclic compound; secondary carboxamide	HIV-1 integrase inhibitor
didanosine Didanosine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.. didanosine : A purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen. An antiviral drug, it is used as a medication to treat HIV/AIDS.	1.98	1	purine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor; geroprotector; HIV-1 reverse transcriptase inhibitor

Condition	Relationship Strength	Studies
HIV Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.	4.89	8
Fungal Diseases [description not available]	3.61	3
Mycoses Diseases caused by FUNGI.	3.61	3
Enterovirus Infections Diseases caused by ENTEROVIRUS.	2.41	1
HIV Coinfection [description not available]	3.35	2
HIV Infections Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).	3.35	2
Infections, RNA Virus [description not available]	2.03	1
Candida Infection [description not available]	2.89	4
Candidiasis Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)	2.89	4
P carinii Pneumonia [description not available]	1.99	1
Cerebral Cryptococcosis [description not available]	1.99	1
AIDS-Related Opportunistic Infections Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.	1.99	1
Pneumonia, Pneumocystis A pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by DYSPNEA, tachypnea, and HYPOXEMIA. Pneumocystis pneumonia is a frequently seen opportunistic infection in AIDS. It is caused by the fungus PNEUMOCYSTIS JIROVECII. The disease is also found in other MAMMALS where it is caused by related species of Pneumocystis.	1.99	1
Meningitis, Cryptococcal Meningeal inflammation produced by CRYPTOCOCCUS NEOFORMANS, an encapsulated yeast that tends to infect individuals with ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunocompromised states. The organism enters the body through the respiratory tract, but symptomatic infections are usually limited to the lungs and nervous system. The organism may also produce parenchymal brain lesions (torulomas). Clinically, the course is subacute and may feature HEADACHE; NAUSEA; PHOTOPHOBIA; focal neurologic deficits; SEIZURES; cranial neuropathies; and HYDROCEPHALUS. (From Adams et al., Principles of Neurology, 6th ed, pp721-2)	1.99	1
Aspergillus Infection [description not available]	1.98	1
C gattii Infection [description not available]	1.98	1
Aspergillosis Infections with fungi of the genus ASPERGILLUS.	1.98	1
Cryptococcosis Fungal infection caused by genus CRYPTOCOCCUS.	1.98	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	1.97	1
Dermatomycoses Superficial infections of the skin or its appendages by any of various fungi.	1.97	1
Fungal Lung Diseases [description not available]	1.97	1
Vaginitis Inflammation of the vagina characterized by pain and a purulent discharge.	1.97	1

pradimicin a

Description

Cross-References

Synonyms (20)

Drug Classes (8)

Bioassays (157)

Research

Studies (62)

Study Types

pradimicin a

Description

Cross-References

Synonyms (20)

Drug Classes (8)

Bioassays (157)

Research

Studies (62)

Study Types

Related Drugs (46)

Related Conditions (22)