pradimicin-a and Enterovirus-Infections

pradimicin-a has been researched along with Enterovirus-Infections* in 1 studies

Other Studies

1 other study(ies) available for pradimicin-a and Enterovirus-Infections

ArticleYear
Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors.
    European journal of medicinal chemistry, 2022, Jul-05, Volume: 237

    We have recently described a novel family of compounds of reduced size and dual anti-HIV and anti-EV71 activity that encompasses tripodal and tetrapodal derivatives. The tripodal prototype, AL-470, has a nitro group at the focal point of the central scaffold and three attached tryptophan residues, each of which bearing an isophthaloyl moiety at the C2 position of the indole ring. A nitro to amino substitution has allowed us now to introduce a chemically addressable functionality to perform further structural modifications consisting of both direct and linker-mediated attachment of several aromatic groups, including the fluorescent dye Alexa Fluor 647 and the antibody-recruiting 2,4-dinitrophenyl motif. Some of the derivatives turned out to be more potent and selective than AL-470 against HIV-1, HIV-2 and EV-A71. The fluorescent probe demonstrated a specific tropism for intestines and lungs, two important niches for the human microbiome in health and disease.

    Topics: Dendrimers; Enterovirus A, Human; Enterovirus Infections; HIV Fusion Inhibitors; HIV-1; HIV-2; Humans; Virus Internalization

2022