pradimicin-a and Disease-Models--Animal

Three N,N-dimethyl pradimicins were synthesized by reductive alkylation of pradimicins A, E and FA-2 and evaluated for antifungal activity, water solubility and acute toxicity in mice. They showed in vitro antifungal activity superior to pradimicin A. N,N-Dimethylpradimicins E and FA-2 showed great improvement in water solubility and animal tolerance. N,N-Dimethylpradimicin FA-2 was effective in 3 experimental in vivo fungal infection models.

Topics: Alkylation; Animals; Anthracyclines; Antibiotics, Antineoplastic; Antifungal Agents; Candida; Disease Models, Animal; Drug Tolerance; Fungi; Male; Mice; Mice, Inbred ICR; Molecular Structure; Mycoses; Oxidation-Reduction; Solubility