pradimicin-a has been researched along with Candidiasis* in 4 studies
4 other study(ies) available for pradimicin-a and Candidiasis
| Article | Year |
|---|---|
Synthesis and antifungal activities of pradimicin A derivatives modification of the alanine moiety.
Chemical modifications of the carboxyl group in the alanine moiety of pradimicin A were performed and in vitro and in vivo antifungal activities of the derivatives were examined in comparison with those of pradimicin A. The amide derivatives showed activities comparable to pradimicin A, indicating that the free carboxyl group can be modified without impairing the antifungal activity. Topics: Alanine; Animals; Anthracyclines; Antibiotics, Antineoplastic; Antifungal Agents; Candidiasis; Mice; Microbial Sensitivity Tests; Structure-Activity Relationship | 1993 |
Synthesis and antifungal activities of alanine-exchanged analogs of pradimicin A.
A series of pradimicin analogs were designed and synthesized to investigate the effect of the amino acid side chain on the antifungal activity. The alanine-exchanged analogs (3a approximately 3q) were synthesized from 4'-N-Cbz-pradimic acid by coupling with appropriate amino acids or their equivalents followed by deblocking. All the D-alpha-amino acid derivatives except D-proline analog, 3k retained the antifungal activity. Topics: Alanine; Animals; Anthracyclines; Antibiotics, Antineoplastic; Antifungal Agents; Candidiasis; Mice; Microbial Sensitivity Tests; Structure-Activity Relationship | 1993 |
In vitro and in vivo antifungal activities of BMS-181184.
Topics: Animals; Anthracyclines; Antibiotics, Antineoplastic; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Candidiasis; Cryptococcosis; Cyclophosphamide; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Structure-Activity Relationship | 1992 |
New antifungal antibiotics pradimicins FA-1 and FA-2: D-serine analogs of pradimicins A and C.
Pradimicin FA-1 was produced via directed biosynthesis with substitution of D-serine for D-alanine in the 15-position of pradimicin A. This substitution was achieved by the addition of D-serine to the culture medium of Actinomadura hibisca P157-2. Likewise, pradimicin FA-2 was co-produced along with pradimicin FA-1 when the pradimicins A and C producing strain, A. hibisca A2493 was grown in D-serine-supplemented medium. The new pradimicin analogs share a common core structure of 5,6-dihydrobenzo[a]naphthacenequinone substituted by D-serine at C-15, but differ in the disaccharide moiety at C-5. Pradimicin FA-1 has an N-methylamino sugar and D-xylose. Pradimicin FA-2 is the des-N-methyl analog of pradimicin FA-1. The in vitro and in vivo antifungal activity of the analogs was comparable to that of pradimicin A. Topics: Amino Acids; Animals; Anthracyclines; Antibiotics, Antineoplastic; Antifungal Agents; Candidiasis; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Fermentation; Fungi; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred ICR; Molecular Structure; Nocardiaceae | 1990 |