| AID294000 | Selectivity ratio for rat adrenergic alpha-1A receptor over rat adrenergic Alpha-1D receptor | 2007 | Bioorganic & medicinal chemistry, Mar-15, Volume: 15, Issue:6
| Synthesis and alpha(1)-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin. |
| AID294002 | Displacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cells | 2007 | Bioorganic & medicinal chemistry, Mar-15, Volume: 15, Issue:6
| Synthesis and alpha(1)-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin. |
| AID36464 | Compound was tested for binding affinity against cloned Alpha-1A adrenergic receptor from bovine brain using radioligand ([3H]prazosin) binding assay | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist. |
| AID294006 | Selectivity ratio of pKi for human adrenergic alpha-1a receptor to pKi for human adrenergic alpha1d receptor | 2007 | Bioorganic & medicinal chemistry, Mar-15, Volume: 15, Issue:6
| Synthesis and alpha(1)-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin. |
| AID63792 | Antagonistic affinity against rat striatum Dopamine receptor D2 | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11
| Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist. |
| AID35467 | Binding affinity was tested on cloned rat Alpha-1D adrenergic receptor | 1997 | Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9
| Pharmacological options in the treatment of benign prostatic hyperplasia. |
| AID36006 | Binding affinity against native Alpha-1 adrenergic receptor from rat cerebral cortex using radioligand [3H]-prazosin binding assay | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist. |
| AID293998 | Selectivity ratio for rat adrenergic alpha-1A receptor over rat adrenergic Alpha-1B receptor | 2007 | Bioorganic & medicinal chemistry, Mar-15, Volume: 15, Issue:6
| Synthesis and alpha(1)-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin. |
| AID422825 | Displacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity. |
| AID35502 | Antagonistic affinity against native rat cortex Alpha-2 adrenergic receptor | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11
| Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist. |
| AID1497042 | Antagonist activity at alpha1B adrenergic receptor in Wistar rat spleen assessed as inhibition of phenylephrine-induced contraction incubated for 30 mins in presence of beta-adrenoceptor blocker propranolol hydrochloride | | | |
| AID422827 | Antagonist activity at rat alpha1A adrenoceptor assessed as inhibition if norepinephrine-induced contraction of vas deference | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity. |
| AID3920 | Antagonistic affinity against cloned human 5-hydroxytryptamine 1A receptor | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11
| Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist. |
| AID37186 | Binding affinity was tested on cloned hamster Alpha-1B adrenergic receptor | 1997 | Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9
| Pharmacological options in the treatment of benign prostatic hyperplasia. |
| AID293999 | Selectivity ratio for rat adrenergic Alpha-1D receptor over rat adrenergic Alpha-1B receptor | 2007 | Bioorganic & medicinal chemistry, Mar-15, Volume: 15, Issue:6
| Synthesis and alpha(1)-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin. |
| AID422829 | Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity. |
| AID1497059 | Binding affinity to human alpha1B adrenergic receptor | | | |
| AID1497044 | Selectivity ratio of compound effect for antagonism of alpha1B adrenergic receptor in Wistar rat spleen to compound effect for antagonism of alpha1A adrenergic receptor in Wistar rat prostatic rat vas deferens | | | |
| AID1497051 | Selectivity ratio of compound effect for displacement of [3H]prazosin from human alpha1B adrenergic receptor expressed in CHO cell membranes to compound effect for displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell m | | | |
| AID294003 | Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells | 2007 | Bioorganic & medicinal chemistry, Mar-15, Volume: 15, Issue:6
| Synthesis and alpha(1)-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin. |
| AID294004 | Selectivity ratio of pKi for human adrenergic alpha-1a receptor to pKi for human adrenergic alpha-1b receptor | 2007 | Bioorganic & medicinal chemistry, Mar-15, Volume: 15, Issue:6
| Synthesis and alpha(1)-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin. |
| AID35168 | Compound was tested for binding affinity against native Alpha-1B adrenergic receptor from rat liver using radioligand ([3H]prazosin) binding assay | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist. |
| AID1497041 | Antagonist activity at alpha1A adrenergic receptor in Wistar rat prostatic rat vas deferens assessed as inhibition of noradrenaline-induced contraction preincubated for 30 mins followed by noradrenaline addition measured after 45 mins in presence of cocai | | | |
| AID63806 | Compound was tested for binding affinity against native Dopamine receptor D2 from rat striatum using radioligand [3H]-spiperone) | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist. |
| AID35151 | Antagonistic affinity against Alpha-1B adrenergic receptor was determined in isolated spleen tissue from rat | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11
| Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist. |
| AID1497048 | Displacement of [3H]prazosin from human alpha1B adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method | | | |
| AID294001 | Displacement of [3H]prazosin from human adrenergic alpha-1a receptor expressed in CHO cells | 2007 | Bioorganic & medicinal chemistry, Mar-15, Volume: 15, Issue:6
| Synthesis and alpha(1)-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin. |
| AID36753 | Binding affinity was tested on human Alpha-1A adrenergic receptor | 1997 | Journal of medicinal chemistry, Apr-25, Volume: 40, Issue:9
| Pharmacological options in the treatment of benign prostatic hyperplasia. |
| AID294005 | Selectivity ratio of pKi for human adrenergic alpha-1d receptor to pKi for human adrenergic alpha-1b receptor | 2007 | Bioorganic & medicinal chemistry, Mar-15, Volume: 15, Issue:6
| Synthesis and alpha(1)-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin. |
| AID1497060 | Selectivity ratio of compound effect for human alpha1B adrenergic receptor to compound effect for human alpha1A adrenergic receptor | | | |
| AID239801 | Binding affinity for alpha 1d adrenoceptor | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Range and sensitivity as descriptors of molecular property spaces in dynamic QSAR analyses. |
| AID37187 | Compound was tested for binding affinity against cloned Alpha-1B adrenergic receptor from hamster smooth muscle using radioligand ([3H]prazosin) binding assay | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist. |
| AID293995 | Antagonist activity against adrenergic alpha-1A receptor in rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contraction | 2007 | Bioorganic & medicinal chemistry, Mar-15, Volume: 15, Issue:6
| Synthesis and alpha(1)-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin. |
| AID422824 | Displacement of [3H]prazosin from human alpha1A adrenoceptor expressed in CHO cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity. |
| AID1497052 | Selectivity ratio of compound effect for displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes to compound effect for displacement of [3H]prazosin from human alpha1A adrenergic receptor expressed in CHO cell m | | | |
| AID422826 | Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity. |
| AID1497047 | Displacement of [3H]prazosin from human alpha1A adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method | | | |
| AID35507 | Binding affinity against native Alpha-2 adrenergic receptor from rat cerebral cortex using radioligand ([3H]rauwolscine) binding assay | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist. |
| AID4407 | Binding affinity against native 5-HT1A-receptors from rat hippocampus using radioligand ([3H]8-hydroxy-2-(di-n-propylamino)-tetraline) binding assay | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist. |
| AID293997 | Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response | 2007 | Bioorganic & medicinal chemistry, Mar-15, Volume: 15, Issue:6
| Synthesis and alpha(1)-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin. |
| AID1497046 | Selectivity ratio of compound effect for antagonism of alpha1D adrenergic receptor in Wistar rat thoracic aorta to compound effect for antagonism of alpha1A adrenergic receptor in Wistar rat prostatic rat vas deferens | | | |
| AID293996 | Antagonist activity against adrenergic Alpha-1B receptor in rat spleen assessed as inhibition of phenylephrine-induced response | 2007 | Bioorganic & medicinal chemistry, Mar-15, Volume: 15, Issue:6
| Synthesis and alpha(1)-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin. |
| AID1497043 | Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride | | | |
| AID1497045 | Selectivity ratio of compound effect for antagonism of alpha1B adrenergic receptor in Wistar rat spleen to compound effect for antagonism of alpha1D adrenergic receptor in Wistar rat thoracic aorta | | | |
| AID1497049 | Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method | | | |
| AID422828 | Antagonist activity at rat Alpha-1B adrenoceptor assessed as inhibition if phenylephrine-induced contraction of spleen | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity. |
| AID239799 | Binding affinity for alpha 1a adrenoceptor | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Range and sensitivity as descriptors of molecular property spaces in dynamic QSAR analyses. |
| AID36909 | Antagonistic affinity against Alpha-1A adrenergic receptor was determined in isolated prostatic vas deferens tissue from rat | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11
| Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist. |
| AID35741 | Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain. | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist. |
| AID239800 | Binding affinity for alpha 1b adrenoceptor | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Range and sensitivity as descriptors of molecular property spaces in dynamic QSAR analyses. |
| AID35608 | Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11
| Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist. |
| AID1497050 | Selectivity ratio of compound effect for displacement of [3H]prazosin from human alpha1B adrenergic receptor expressed in CHO cell membranes to compound effect for displacement of [3H]prazosin from human alpha1A adrenergic receptor expressed in CHO cell m | | | |
| AID37043 | Binding affinity against native Alpha-1A adrenergic receptor from rat hippocampus pretreated with chloroethylclonidine using radioligand ([3H]prazosin) binding assay | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist. |
| AID1497061 | Selectivity ratio of compound effect for human alpha1B adrenergic receptor to compound effect for human alpha1D adrenergic receptor | | | |
| AID1345908 | Human alpha1A-adrenoceptor (Adrenoceptors) | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist. |
| AID1345971 | Human alpha1D-adrenoceptor (Adrenoceptors) | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist. |
| AID1345920 | Rat alpha1D-adrenoceptor (Adrenoceptors) | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist. |
| AID1346000 | Human alpha1B-adrenoceptor (Adrenoceptors) | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |