Compounds > cyclazosin
Page last updated: 2024-09-03

cyclazosin and prazosin

cyclazosin has been researched along with prazosin in 12 studies

Compound Research Comparison

Studies
(cyclazosin)		Trials
(cyclazosin)		Recent Studies (post-2010)
(cyclazosin)		Studies
(prazosin)		Trials
(prazosin)		Recent Studies (post-2010) (prazosin)
22047,914713682

Protein Interaction Comparison

ProteinTaxonomycyclazosin (IC50)prazosin (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)5.87
Interstitial collagenaseHomo sapiens (human)4.036
Alpha-2A adrenergic receptorHomo sapiens (human)2.638
Matrix metalloproteinase-9Homo sapiens (human)6.963
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.0008
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)0.0078
Alpha-2B adrenergic receptorHomo sapiens (human)0.29
Alpha-2C adrenergic receptorHomo sapiens (human)0.647
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.0008
Alpha-1D adrenergic receptorHomo sapiens (human)0.0007
Bromodomain-containing protein 2Homo sapiens (human)0.0009
Alpha-1A adrenergic receptorHomo sapiens (human)0.0006
Alpha-1B adrenergic receptorHomo sapiens (human)0.0006
5-hydroxytryptamine receptor 2BHomo sapiens (human)4.118
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.0008
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)9.9
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.5849
Multidrug and toxin extrusion protein 1Homo sapiens (human)1.6

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (41.67)18.2507
2000's5 (41.67)29.6817
2010's1 (8.33)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Crucianelli, M; Giardinà, D; Leonardi, A; Melchiorre, C; Poggesi, E; Romanelli, R1
Ballard, S; Blagg, J; Fox, D; Kenny, B1
Budriesi, R; Chiarini, A; Leonardi, A; Melchiorre, C; Minarini, A1
Pedretti, A; Testa, B; Villa, L; Vistoli, G1
Giardinà, D; Gulini, U; Massi, M; Melchiorre, C; Piloni, MG; Pompei, P; Rafaiani, G1
Crucianelli, M; Giardinà, D; Melchiorre, C; Taddei, C; Testa, R1
Angeli, P; Giardinà, D; Gulini, U; Leonardi, A; Marucci, G; Melchiorre, C; Poggesi, E; Polimanti, O; Sagratini, G1
Angeli, P; Buccioni, M; Giardinà, D; Gulini, U; Leonardi, A; Marucci, G; Melchiorre, C; Poggesi, E; Sagratini, G1
Bexis, S; Docherty, JR1
Imanishi, A; Latifpour, J; Ueda, S; Yamamoto, Y; Yono, M; Yoshida, M1
Abdelkarim, H; Albee, LJ; Gao, X; Gaponenko, V; Majetschak, M; Volkman, BF1
Alsufyani, HA; Docherty, JR; McCormick, PA1

Reviews

1 review(s) available for cyclazosin and prazosin

ArticleYear
Pharmacological options in the treatment of benign prostatic hyperplasia.
    Journal of medicinal chemistry, 1997, Apr-25, Volume: 40, Issue:9

    Topics: 5-alpha Reductase Inhibitors; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Controlled Clinical Trials as Topic; Endothelins; Enzyme Inhibitors; Humans; Male; Prostate; Prostatic Hyperplasia; Receptors, Adrenergic, alpha; Structure-Activity Relationship

1997

Other Studies

11 other study(ies) available for cyclazosin and prazosin

ArticleYear
Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist.
    Journal of medicinal chemistry, 1996, Nov-08, Volume: 39, Issue:23

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Cattle; Cerebral Cortex; CHO Cells; COS Cells; Cricetinae; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Quinazolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Stereoisomerism

1996
Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist.
    Bioorganic & medicinal chemistry letters, 1998, Jun-02, Volume: 8, Issue:11

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Drug Design; Humans; In Vitro Techniques; Male; Quinazolines; Quinoxalines; Rats; Receptors, Adrenergic, alpha-1; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Spleen; Structure-Activity Relationship; Vas Deferens

1998
Range and sensitivity as descriptors of molecular property spaces in dynamic QSAR analyses.
    Journal of medicinal chemistry, 2005, Jul-28, Volume: 48, Issue:15

    Topics: Chemical Phenomena; Chemistry, Physical; Ligands; Models, Molecular; Molecular Conformation; Monte Carlo Method; Quantitative Structure-Activity Relationship; Receptors, Adrenergic, alpha-1; Solvents

2005
Structure-activity relationships in prazosin-related compounds. 2. Role of the piperazine ring on alpha-blocking activity.
    Journal of medicinal chemistry, 1993, Mar-19, Volume: 36, Issue:6

    Topics: Adrenergic alpha-Antagonists; Animals; Hemodynamics; Male; Piperazines; Prazosin; Quinazolines; Quinoxalines; Rats; Rats, Inbred SHR; Stereoisomerism; Structure-Activity Relationship

1993
Receptor binding profile of cyclazosin, a new alpha 1B-adrenoceptor antagonist.
    European journal of pharmacology, 1995, Dec-04, Volume: 287, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Brain; Male; Prazosin; Quinazolines; Quinoxalines; Rats; Receptors, Adrenergic, alpha-1

1995
Searching for cyclazosin analogues as alpha(1B)-adrenoceptor antagonists.
    Farmaco (Societa chimica italiana : 1989), 2003, Volume: 58, Issue:7

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Binding Sites; CHO Cells; Clone Cells; Cricetinae; Guinea Pigs; Humans; Male; Prazosin; Quinazolines; Quinoxalines; Rats; Receptors, Adrenergic, alpha-1; Spleen; Vas Deferens

2003
Synthesis and alpha(1)-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin.
    Bioorganic & medicinal chemistry, 2007, Mar-15, Volume: 15, Issue:6

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Aorta; Binding, Competitive; Furans; Male; Molecular Structure; Prazosin; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Spleen; Stereoisomerism; Structure-Activity Relationship; Vas Deferens

2007
Role of alpha1-adrenoceptor subtypes in the effects of methylenedioxy methamphetamine (MDMA) on body temperature in the mouse.
    British journal of pharmacology, 2008, Volume: 153, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Body Temperature; Fever; Male; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Prazosin; Quinazolines; Quinoxalines; Receptors, Adrenergic, alpha-1; Thymine

2008
Differential effects of prazosin and naftopidil on pelvic blood flow and nitric oxide synthase levels in spontaneously hypertensive rats.
    Journal of receptor and signal transduction research, 2008, Volume: 28, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Hypertension; Male; Naphthalenes; Nitric Oxide Synthase; Pelvis; Penis; Piperazines; Prazosin; Prostate; Quinazolines; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha; Regional Blood Flow; Urinary Bladder

2008
Partial agonist activity of α1-adrenergic receptor antagonists for chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3.
    PloS one, 2018, Volume: 13, Issue:9

    Topics: Adrenergic alpha-1 Receptor Antagonists; beta-Arrestins; Binding Sites; Cells, Cultured; Chemokine CXCL12; Chemotaxis; Drug Evaluation, Preclinical; Drug Repositioning; HEK293 Cells; Humans; MAP Kinase Signaling System; Myocytes, Smooth Muscle; Nuclear Magnetic Resonance, Biomolecular; Prazosin; Quinazolines; Quinoxalines; Receptors, CXCR; Receptors, CXCR4

2018
Both α
    Pharmacological reports : PR, 2021, Volume: 73, Issue:1

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Animals; Dose-Response Relationship, Drug; Male; Muscle Contraction; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Spleen; Thymine; Yohimbine

2021