Page last updated: 2024-10-24

eye blink reflex

Definition

Target type: biologicalprocess

The reflex process in which a mechanical stimulus applied to the eye elicits a response of the eyelid closing. [GOC:dph, PMID:2913208]

The eye blink reflex is a complex, involuntary response triggered by stimuli that threaten the eye. It serves as a protective mechanism to shield the delicate ocular structures from potential harm. This reflex is mediated by a neural pathway involving sensory, motor, and interneurons. Here is a detailed breakdown of the process:

1. **Stimulus Detection:** The initial step involves the detection of a threatening stimulus. This could be something as simple as a puff of air, a bright light, or a foreign object approaching the eye. Sensory receptors, such as the corneal receptors, located on the surface of the eye, detect these stimuli and send signals along the sensory nerve (the ophthalmic branch of the trigeminal nerve).

2. **Signal Transmission to the Brain:** The sensory nerve transmits the signal to the trigeminal ganglion, a cluster of nerve cell bodies. From there, the signal is relayed to the brainstem, specifically to the pons.

3. **Synaptic Transmission:** Within the pons, the signal synapses with interneurons. These interneurons are responsible for integrating and processing the incoming signal.

4. **Motor Neuron Activation:** The interneurons then transmit the signal to the motor neurons located in the facial nerve nucleus within the brainstem. This activation of the motor neurons triggers the contraction of the orbicularis oculi muscle, the muscle responsible for closing the eyelid.

5. **Eyelid Closure:** The contraction of the orbicularis oculi muscle leads to the rapid closure of the eyelid, shielding the eye from the threatening stimulus.

6. **Reflex Completion:** The blink reflex is typically very fast, occurring within a fraction of a second. The entire process, from stimulus detection to eyelid closure, is highly coordinated and automatic, ensuring rapid protection of the eye.

This reflex can be modified by higher brain centers, allowing for conscious control of blinking. For example, we can voluntarily blink to remove dust particles from the eye. However, the basic reflex arc remains intact, providing a crucial protective mechanism for the eye.'
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Proteins (1)

ProteinDefinitionTaxonomy
Voltage-dependent calcium channel gamma-2 subunitA voltage-dependent calcium channel gamma-2 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y698]Homo sapiens (human)

Compounds (3)

CompoundDefinitionClassesRoles
tacrinetacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.

Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
acridines;
aromatic amine
EC 3.1.1.7 (acetylcholinesterase) inhibitor
nimodipinenimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.

Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
2-methoxyethyl ester;
C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
isopropyl ester
antihypertensive agent;
calcium channel blocker;
cardiovascular drug;
vasodilator agent
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