4-azaindole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

4-Azaindole is a heterocyclic compound containing a fused pyrrole and pyridine ring system. It has been investigated for its potential pharmacological properties, including its ability to act as a serotonin receptor agonist and an inhibitor of the enzyme monoamine oxidase. 4-Azaindole is also a key building block in the synthesis of various natural products and pharmaceutical compounds. Due to its unique structural features and biological activities, 4-azaindole has attracted significant attention from synthetic organic chemists and medicinal chemists. Research on 4-azaindole focuses on exploring its diverse applications in drug discovery and development, materials science, and organic synthesis.'

Cross-References

ID Source	ID
PubMed CID	9226
CHEMBL ID	5184883
SCHEMBL ID	12565
SCHEMBL ID	17850816
SCHEMBL ID	16662494
MeSH ID	M0513486

Synonyms (38)

Synonym
AC-088 ,
1,4-diazaindene
1h-pyrrolo(3,2-b)pyridine
BB 0260112
4-azaindole ,
272-49-1
A-9485
brn 0109683
1h-pyrrolo[3,2-b]pyridine
AKOS005256883
pyrrolopyridine
5-23-06-00303 (beilstein handbook reference)
FT-0601479
PS-4925
AM20051025
4jp ,
PB18523
SCHEMBL12565
mfcd00971977
SY019307
pyrrolo[3,2-b]pyridine
XWIYUCRMWCHYJR-UHFFFAOYSA-N
W-204756
4-azaindole;4-azaindole
P2041
SCHEMBL17850816
DTXSID00181666
1h-pyrrolo[3,2-b]pyridine, aldrichcpr
Z1925930568
SCHEMBL16662494
CS-D1166
CHEMBL5184883
BBL103666
STL557476
BCP26719
Q27454752
EN300-94605
HY-20362

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay ID	Title	Year	Journal	Article
AID1891830	Basic dissociation constant, pKa of the compound	2022	Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9	Development of Azaindole-Based Frameworks as Potential Antiviral Agents and Their Future Perspectives.
AID1891831	Lipid-water distribution ratio of the compound	2022	Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9	Development of Azaindole-Based Frameworks as Potential Antiviral Agents and Their Future Perspectives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (22.22)	29.6817
2010's	13 (72.22)	24.3611
2020's	1 (5.56)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.81

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	29.81 (24.57)
Research Supply Index	2.94 (2.92)
Research Growth Index	4.83 (4.65)
Search Engine Demand Index	24.97 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (29.81)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (5.56%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (94.44%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
indole [no description available]	3.51	1	indole; polycyclic heteroarene	Escherichia coli metabolite
melatonin [no description available]	7.04	1	acetamides; tryptamines	anticonvulsant; central nervous system depressant; geroprotector; hormone; human metabolite; immunological adjuvant; mouse metabolite; radical scavenger
urea pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.	2.11	1	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
2,2'-dipyridyl 2,2'-Dipyridyl: A reagent used for the determination of iron.. 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.	2.11	1	bipyridine	chelator; ferroptosis inhibitor
benzimidazole 1H-benzimidazole : The 1H-tautomer of benzimidazole.	2.5	2	benzimidazole; polycyclic heteroarene
tryptophan Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.	7.45	2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan	antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
quinoline [no description available]	2.11	1	azaarene; mancude organic heterobicyclic parent; ortho-fused heteroarene; quinolines
6-azaindole [no description available]	3.62	2
5-azaindole [no description available]	3.89	3
indazoles Indazoles: A group of heterocyclic aromatic organic compounds consisting of the fusion of BENZENE and PYRAZOLES.	2.11	1	indazole
7-azaindole [no description available]	3.51	1	pyrrolopyridine
sodium hydroxide Sodium Hydroxide: A highly caustic substance that is used to neutralize acids and make sodium salts. (From Merck Index, 11th ed)	2.07	1	alkali metal hydroxide
ruthenium Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.	2.11	1	iron group element atom; platinum group metal atom
bms-488043 BMS-488043: anti-HIV agent	3.51	1
bms 806 BMS 806: prevents entry of HIV into cells by binding HIV envelope protein gp120; no further info available 4/2002	2.08	1
7-azatryptophan 7-azatryptophan: RN given refers to cpd without isomeric designation; structure	2.05	1
bms-585248 [no description available]	3.51	1

Condition	Relationship Strength	Studies
Grippe [description not available]	3.33	1
Influenza, Human An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.	3.33	1
ER-Negative PR-Negative HER2-Negative Breast Cancer [description not available]	2.15	1
Triple Negative Breast Neoplasms Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.	2.15	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.1	1
Infections, Staphylococcal [description not available]	2.11	1
Bacterial Infections, Gram-Positive [description not available]	2.11	1
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	2.11	1
Gram-Positive Bacterial Infections Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.	2.11	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.02	1

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