6-azaindole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

6-Azaindole is a heterocyclic compound that is structurally similar to indole, with a nitrogen atom replacing the carbon atom at position 6. It is an important synthetic building block for various bioactive compounds, including pharmaceuticals and agrochemicals. 6-Azaindole has shown promising activity in different therapeutic areas, including anti-cancer, anti-inflammatory, and anti-microbial. Its synthesis is typically achieved through the condensation of o-aminobenzaldehyde with a suitable carbonyl compound. Research on 6-azaindole is driven by its potential applications in drug discovery and material science. Its unique chemical properties and biological activities make it a valuable target for further investigation.'

Cross-References

ID Source	ID
PubMed CID	9219
CHEMBL ID	5208607
SCHEMBL ID	12470
SCHEMBL ID	22959960
MeSH ID	M0490829

Synonyms (38)

Synonym
AC-1651
1,6-diazaindene
brn 0109685
harmyrine
1h-pyrrolo(2,3-c)pyridine
inchi=1/c7h6n2/c1-3-8-5-7-6(1)2-4-9-7/h1-5,9
6-azaindole ,
271-29-4
A-9495
1h-pyrrolo[2,3-c]pyridine
AKOS000782863
A5292
pyrrolo[2,3-c]pyridine
5-23-06-00305 (beilstein handbook reference)
271-28-3
AKOS006240281
6h-pyrrolo[2,3-c]pyridine
BP-20630
FT-0601477
PS-4926
6-azaindol
AM20051017
PB21773
SCHEMBL12470
mfcd01686899
SY005848
DTXSID20181562
1h-pyrrolo[2,3-c]pyridine, aldrichcpr
CS-W002819
BBL103029
STL556838
1h-inden-2-amine, 5,6-diethyl-2,3-dihydro-, hydrochloride (1:1)
BCP26482
EN300-56937
SCHEMBL22959960
P2530
Z871773918
CHEMBL5208607

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay ID	Title	Year	Journal	Article
AID1891831	Lipid-water distribution ratio of the compound	2022	Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9	Development of Azaindole-Based Frameworks as Potential Antiviral Agents and Their Future Perspectives.
AID1891830	Basic dissociation constant, pKa of the compound	2022	Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9	Development of Azaindole-Based Frameworks as Potential Antiviral Agents and Their Future Perspectives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (36.36)	29.6817
2010's	4 (36.36)	24.3611
2020's	3 (27.27)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	22.78 (24.57)
Research Supply Index	2.48 (2.92)
Research Growth Index	4.68 (4.65)
Search Engine Demand Index	21.17 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (22.78)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (9.09%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (90.91%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
indole [no description available]	3.51	1	indole; polycyclic heteroarene	Escherichia coli metabolite
pyrazole 1H-pyrazole : The 1H-tautomer of pyrazole.	2.04	1	pyrazole
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	3.01	4	pyrrole; secondary amine
5-azaindole [no description available]	3.87	3
7-azaindole [no description available]	3.51	1	pyrrolopyridine
4-azaindole [no description available]	3.62	2
oxazoles Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.	7.25	1	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
meridianin g meridianin G: from the tunicate Aplidium meridianum; structure in first source	2.15	1
bms-488043 BMS-488043: anti-HIV agent	3.51	1
bms-585248 [no description available]	3.51	1
bms-663068 fostemsavir: an HIV-1 attachment inhibitor; structure in first source	7.1	1
marinoquinoline a marinoquinoline A: pyrroloquinoline from Ohtaekwangia kribbensis (Bacteroidetes); showed weak antibacterial and antifungal activities and moderate cytotoxicity against four growing mammalian cell lines; structure in first source. marinoquinoline A : A pyrroloquinoline that is 3H-pyrrolo[2,3-c]quinoline substituted by a methyl group at position 4. It is a natural product found in Ohtaekwangia kribbensis and Rapidithrix thailandica.	7.25	1	pyrroloquinoline	bacterial metabolite

Condition	Relationship Strength	Studies
Grippe [description not available]	3.33	1
Influenza, Human An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.	3.33	1
Autoimmune Diabetes [description not available]	2.25	1
Diabetes Mellitus, Type 1 A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.	2.25	1
HIV Coinfection [description not available]	2.13	1
HIV Infections Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).	2.13	1

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