cymantrene profile

Cymantrene, also known as bis(η5-cyclopentadienyl)manganese tricarbonyl, is an organometallic compound with the formula (η5-C5H5)2Mn(CO)3. It is a yellow, air-stable solid. Cymantrene is a versatile starting material for the synthesis of other organometallic compounds and has found applications in various fields, including catalysis, materials science, and medicine. Its unique structure and properties have attracted significant interest from researchers. For instance, the presence of the manganese atom with its carbonyl ligands allows for facile reactions with a variety of reagents. Its sandwich structure and the electron-withdrawing nature of the carbonyl groups influence its reactivity and stability. Cymantrene has been investigated as a catalyst for a variety of reactions, including the synthesis of organic compounds, the oxidation of organic molecules, and the polymerization of alkenes. Its ability to coordinate to various substrates makes it suitable for use in materials science, particularly in the development of novel polymers, sensors, and electronic devices. Cymantrene has also shown potential in medicinal chemistry, with studies exploring its activity against cancer cells and its use in the development of anti-inflammatory drugs. The study of cymantrene provides valuable insights into the chemistry of transition metals and their interaction with organic molecules. It serves as a model system for understanding the fundamental principles of organometallic chemistry, which has far-reaching implications for various chemical processes and technologies.'

ID Source	ID
PubMed CID	61551
MeSH ID	M0130342

Synonym
tricarbonyl(eta-cyclopentadienyl)manganese
cyklopentadientrikarbonylmanganium [czech]
hsdb 7191
manganese, cyclopentadienyltricarbonyl
manganese cyclopentadienyl tricarbonyl
manganese, tricarbonyl(eta5-2,4-cyclopentadien-1-yl)-
cymantrene
einecs 235-142-4
zcr03b0nfi ,
unii-zcr03b0nfi
tricarbonyl(.eta.-cyclopentadienyl)manganese
manganese cyclopentadienyl tricarbonyl [hsdb]
CENDTHIEZAWVHS-UHFFFAOYSA-N
Q1878572
DTXSID501014736

Excerpt	Reference	Relevance
"Cymantrene CpMn(CO)(3) is a robust organometallic group, which is stable in air and water and easy to functionalize."	( Protease-activatable organometal-Peptide bioconjugates with enhanced cytotoxicity on cancer cells. Gust, R; Hu, W; Neundorf, I; Onambele, LA; Ott, I; Prokop, A; Schatzschneider, U; Splith, K, 2010)	1.08

Excerpt	Reference	Relevance
" These results suggest that CMT does not require metabolic activation to produce toxic effects, and that prior exposure to CMT produces tolerance."	( The acute toxicity of cyclopentadienyl manganese tricarbonyl in the rat. Hanzlik, RP; Hogberg, K; Penney, DA; Traiger, GJ, 1985)	0.27

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (14.29)	18.7374
1990's	5 (23.81)	18.2507
2000's	7 (33.33)	29.6817
2010's	4 (19.05)	24.3611
2020's	2 (9.52)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	21 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
nitroxyl nitroxyl: hydroxamic acid oxidized to nitroxyl free radical. nitroxyl : A nitrogen oxoacid consisting of an oxygen atom double-bonded to an NH group.	2.41	1	nitrogen oxoacid
phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.	2.67	3	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	2.04	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
skatole [no description available]	1.99	1	methylindole	human metabolite; mammalian metabolite
3-xylene m-xylene : A xylene carrying methyl groups at positions 1 and 3.	1.98	1	xylene
manganese Manganese: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035). manganese(4+) : A manganese cation that is monoatomic and has a formal charge of +4.	8.69	10	elemental manganese; manganese group element atom	Escherichia coli metabolite; micronutrient
2-imidazoline 2-imidazoline: RN given refers to parent cpd; structure. imidazoline : An imidazoline compound having the double bond at the 2-position.	7.41	1	imidazolines
biotin vitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.	1.97	1	biotins; vitamin B7	coenzyme; cofactor; Escherichia coli metabolite; fundamental metabolite; human metabolite; mouse metabolite; nutraceutical; prosthetic group; Saccharomyces cerevisiae metabolite
enkephalin, leucine Enkephalin, Leucine: One of the endogenous pentapeptides with morphine-like activity. It differs from MET-ENKEPHALIN in the LEUCINE at position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.. Leu-enkephalin : A pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-leucine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide produced in vertebrate species, including rodents, primates and humans that results from decomposition of proenkephalin or dynorphin and exhibits antinociceptive properties.	2.04	1	pentapeptide; peptide zwitterion	analgesic; delta-opioid receptor agonist; human metabolite; mu-opioid receptor agonist; neurotransmitter; rat metabolite
phenylalanine methyl ester phenylalanine methyl ester: RN given refers to (L)-isomer. methyl L-phenylalaninate : An alpha-amino acid ester that is the methyl ester of L-phenylalanine.	2.04	1	alpha-amino acid ester; L-phenylalanine derivative

Condition	Relationship Strength	Studies
Manganese Poisoning Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include CONFUSION; HALLUCINATIONS; and an extrapyramidal syndrome (PARKINSON DISEASE, SECONDARY) that includes rigidity; DYSTONIA; retropulsion; and TREMOR. (Adams, Principles of Neurology, 6th ed, p1213)	2.38	2
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	1.98	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.96	1
Edema, Pulmonary [description not available]	1.96	1
Absence Seizure [description not available]	1.96	1
Pulmonary Edema Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.	1.96	1
Seizures Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.	1.96	1

cymantrene

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Toxicity

Research

Studies (21)

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Research Demand Index: 22.33

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