positive regulation of tau-protein kinase activity

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate or extent of tau-protein kinase activity. [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780]

Positive regulation of tau-protein kinase activity is a complex biological process that involves a series of molecular events leading to the activation of tau-protein kinases. These kinases play a crucial role in regulating the phosphorylation of tau protein, a microtubule-associated protein that plays a vital role in neuronal function. Dysregulation of tau phosphorylation is implicated in several neurodegenerative diseases, including Alzheimer's disease.

**Key steps involved in positive regulation of tau-protein kinase activity:**

1. **Binding of Kinase Activator:** Certain molecules, known as kinase activators, bind to the kinase and induce conformational changes, leading to activation. These activators can include small molecules, proteins, or even post-translational modifications like phosphorylation.

2. **Releasing of Inhibitory Domains:** Some kinases have inhibitory domains that prevent their activity. Kinase activators can bind to these domains and release them, allowing the kinase to become active.

3. **Post-Translational Modifications:** Post-translational modifications, such as phosphorylation or acetylation, can also regulate kinase activity. These modifications can alter the conformation or binding affinity of the kinase, leading to increased activity.

4. **Scaffold Proteins:** Scaffold proteins can bring together kinase and its substrate, facilitating the phosphorylation process. This brings the kinase and its substrate into close proximity, increasing the probability of phosphorylation.

5. **Signaling Pathways:** Kinase activity is often regulated by upstream signaling pathways. These pathways can activate kinases through a cascade of phosphorylation events.

6. **Changes in Cellular Environment:** Changes in the cellular environment, such as stress or nutrient availability, can also affect kinase activity. These changes can trigger signaling pathways that ultimately lead to kinase activation.

**Overall, the positive regulation of tau-protein kinase activity is a multi-faceted process involving a diverse range of molecular mechanisms. This regulation is critical for maintaining neuronal function and preventing neurodegenerative diseases. Further research is needed to fully understand the complexities of this process and to develop therapeutic interventions for diseases related to tau-protein kinase dysregulation.**'
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Proteins (1)

Compounds (60)