Assay ID | Title | Year | Journal | Article |
AID247910 | In vitro inhibitory activity against human leukemia K562IU cell line | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Antitumor activity of C-methyl-beta-D-ribofuranosyladenine nucleoside ribonucleotide reductase inhibitors. |
AID1168487 | Growth inhibition of human MCF7 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID595460 | Antiproliferative activity against human K562 cells after 72 hrs by MTS assay | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5
| Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents. |
AID244279 | Percent displacement of [3H]CGS-21680 binding to adenosine A2A receptors of bovine striatal membranes at 0.00005 M | 2005 | Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5
| Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. |
AID33330 | Inhibitory activity against Adenosine A3 receptor by inhibition of [3H](R)-PIA binding to rat testis membranes | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
| 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies. |
AID248027 | In vitro inhibitory activity against human colon carcinoma HT-29 cell line | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Antitumor activity of C-methyl-beta-D-ribofuranosyladenine nucleoside ribonucleotide reductase inhibitors. |
AID1168479 | Cytotoxicity against human HL60 cells at 20 to 100 uM after 24 to 48 hrs in presence of 2 mM VPA by trypan blue dye exclusion method | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID340156 | Antitumor activity against human MCF7 cells after 48 hrs by MTS assay | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives. |
AID1168485 | Growth inhibition of human HUT78 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID248110 | In vitro inhibitory activity against human myelogenous leukemia K562 cell line | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Antitumor activity of C-methyl-beta-D-ribofuranosyladenine nucleoside ribonucleotide reductase inhibitors. |
AID1168463 | Induction of cell cycle arrest in human HL60 cells assessed as accumulation at S phase at 20 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 54%) | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID595461 | Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5
| Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents. |
AID1168478 | Induction of apoptosis in human HL60 cells after 24 to 48 hrs by acridine orange and ethidium bromide staining based fluorescence microscopy | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID233378 | Inhibitory selectivity at Adenosine A3 receptor compared to Adenosine 1 receptor. | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
| 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies. |
AID244278 | Percent displacement of [125I]AB-MECA binding to adenosine A3 receptors of bovine cortical membranes at 0.00005 M | 2005 | Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5
| Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. |
AID33022 | Ability to displace [3H]-CGS- 21680 from Adenosine A2A receptor of rat brain striatum at 10e-5 M | 2002 | Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6
| Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues. |
AID1168467 | Induction of cell cycle arrest in human HL60 cells assessed as accumulation at G2M phase at 20 uM in presence of 2 mM VPA after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 12%) | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID340153 | Antitumor activity against human K562 cells after 48 hrs by MTS assay | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives. |
AID32002 | Inhibitory activity at Adenosine A1 receptor by inhibition of [3H]CHA binding to bovine brain cortical membranes. | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
| 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies. |
AID233377 | Inhibitory selectivity at Adenosine 2A receptor compared to Adenosine 1 receptor. | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
| 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies. |
AID1168480 | Cytotoxicity against human HL60 cells at 20 to 100 uM after 24 to 48 hrs in presence of 1 mM VPA by trypan blue dye exclusion method | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID1168482 | Induction of apoptosis in human HL60 cells at 20 uM in presence of 1 mM VPA after 24 to 48 hrs by acridine orange and ethidium bromide staining based fluorescence microscopy | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID1168464 | Induction of cell cycle arrest in human HL60 cells assessed as accumulation at G2M phase at 20 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 12%) | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID31854 | Inhibition of [3H]CHA (N6-cyclohexyl adenosine) to rat brain membrane Adenosine A1 receptor | 2002 | Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6
| Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues. |
AID33205 | Binding affinity determined by displacement of specific binding of [125I]N-(4-amino-3-iodophenethyl)-adenosine in membranes of CHO cells stably transfected with the rat Adenosine A3 receptor | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors. |
AID595459 | Antiproliferative activity against human HeLa cells after 72 hrs by MTS assay | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5
| Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents. |
AID86858 | Inhibition HCV NS5B-mediated RNA synthesis | 2004 | Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9
| Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase. |
AID1168484 | Growth inhibition of human K562 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID340154 | Antitumor activity against human CaCo2 cells after 48 hrs by MTS assay | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives. |
AID244280 | Percent displacement of [3H]DPCPX binding to adenosine A1 receptors of bovine cortical membranes at 0.00005 M | 2005 | Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5
| Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. |
AID1168477 | Cytotoxicity against human HL60 cells after 24 to 48 hrs by trypan blue dye exclusion method | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID1168483 | Growth inhibition of human HL60 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID33765 | Binding affinity determined on Adenosine A2A receptor in rat striatal membranes by measuring displacement of specific [3H]-CGS- 21680 as radioligand. | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors. |
AID31885 | Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand. | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors. |
AID595463 | Antiproliferative activity against human Caco2 cells after 72 hrs by MTS assay | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5
| Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents. |
AID33922 | Inhibitory activity against Adenosine A2A receptor by inhibition of [3H]-CGS- 21680 binding to bovine striatal membranes | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10
| 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies. |
AID1168462 | Induction of cell cycle arrest in human HL60 cells assessed as accumulation at G1 phase at 20 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 32%) | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID1168489 | Growth inhibition of human Caco2 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID1168481 | Induction of apoptosis in human HL60 cells at 20 uM in presence of 2 mM VPA after 24 to 48 hrs by acridine orange and ethidium bromide staining based fluorescence microscopy | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID248043 | In vitro inhibitory activity against human breast carcinoma MCF-7 cell line | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Antitumor activity of C-methyl-beta-D-ribofuranosyladenine nucleoside ribonucleotide reductase inhibitors. |
AID1168466 | Induction of cell cycle arrest in human HL60 cells assessed as accumulation at S phase at 20 uM in presence of 2 mM VPA after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 54%) | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID595462 | Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5
| Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents. |
AID86857 | Inhibition HCV RNA replication | 2004 | Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9
| Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase. |
AID1168443 | Half life in RPMI-1640 medium containing 10% fetal calf serum assessed as compound disappearance by HPLC-DAD-ESI-MS method | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID1168486 | Growth inhibition of human HT-29 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID1168488 | Growth inhibition of human HeLa cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
AID33019 | Selectivity for Adenosine A2A over Adenosine A1 receptor | 2002 | Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6
| Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues. |
AID33490 | Selectivity for Adenosine A3 over Adenosine A1 receptor | 2002 | Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6
| Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues. |
AID340155 | Antitumor activity against human HT29 cells after 48 hrs by MTS assay | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives. |
AID1168465 | Induction of cell cycle arrest in human HL60 cells assessed as accumulation at G1 phase at 20 uM in presence of 2 mM VPA after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 32%) | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |