Page last updated: 2024-12-08

pyrrolidino-benzylphenoxyethanamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID164472
CHEMBL ID14608
SCHEMBL ID7140970
MeSH IDM0220505

Synonyms (15)

Synonym
pyrrolidino-benzylphenoxyethanamine
1-[2-(4-benzyl-phenoxy)-ethyl]-pyrrolidine
bdbm50085279
CHEMBL14608 ,
27P ,
1-[2-(4-benzylphenoxy)ethyl]pyrrolidine
147664-41-3
pyrrolidine, 1-(2-(4-(phenylmethyl)phenoxy)ethyl)-
SCHEMBL7140970
pyrolidino-bpe
pyrrolidine,1-[2-[4-(phenylmethyl)phenoxy]ethyl]-
DTXSID70163772
1-(2-(4-benzylphenoxy)ethyl)pyrrolidine
pyrrolidine, 1-[2-[4-(phenylmethyl)phenoxy]ethyl]-
Q27452773
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Leukotriene A-4 hydrolaseHomo sapiens (human)IC50 (µMol)0.02600.00051.28547.6500AID99747; AID99748; AID99749
Leukotriene B4 receptor 1Homo sapiens (human)IC50 (µMol)0.02600.00080.30913.2500AID99748
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (15)

Processvia Protein(s)Taxonomy
proteolysisLeukotriene A-4 hydrolaseHomo sapiens (human)
lipid metabolic processLeukotriene A-4 hydrolaseHomo sapiens (human)
response to zinc ionLeukotriene A-4 hydrolaseHomo sapiens (human)
leukotriene biosynthetic processLeukotriene A-4 hydrolaseHomo sapiens (human)
protein metabolic processLeukotriene A-4 hydrolaseHomo sapiens (human)
peptide catabolic processLeukotriene A-4 hydrolaseHomo sapiens (human)
response to peptide hormoneLeukotriene A-4 hydrolaseHomo sapiens (human)
type I pneumocyte differentiationLeukotriene A-4 hydrolaseHomo sapiens (human)
muscle contractionLeukotriene B4 receptor 1Homo sapiens (human)
inflammatory responseLeukotriene B4 receptor 1Homo sapiens (human)
immune responseLeukotriene B4 receptor 1Homo sapiens (human)
G protein-coupled receptor signaling pathwayLeukotriene B4 receptor 1Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathwayLeukotriene B4 receptor 1Homo sapiens (human)
leukotriene signaling pathwayLeukotriene B4 receptor 1Homo sapiens (human)
neuropeptide signaling pathwayLeukotriene B4 receptor 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (13)

Processvia Protein(s)Taxonomy
RNA bindingLeukotriene A-4 hydrolaseHomo sapiens (human)
aminopeptidase activityLeukotriene A-4 hydrolaseHomo sapiens (human)
epoxide hydrolase activityLeukotriene A-4 hydrolaseHomo sapiens (human)
leukotriene-A4 hydrolase activityLeukotriene A-4 hydrolaseHomo sapiens (human)
protein bindingLeukotriene A-4 hydrolaseHomo sapiens (human)
peptidase activityLeukotriene A-4 hydrolaseHomo sapiens (human)
zinc ion bindingLeukotriene A-4 hydrolaseHomo sapiens (human)
tripeptide aminopeptidase activityLeukotriene A-4 hydrolaseHomo sapiens (human)
metalloaminopeptidase activityLeukotriene A-4 hydrolaseHomo sapiens (human)
nucleotide bindingLeukotriene B4 receptor 1Homo sapiens (human)
leukotriene receptor activityLeukotriene B4 receptor 1Homo sapiens (human)
G protein-coupled peptide receptor activityLeukotriene B4 receptor 1Homo sapiens (human)
leukotriene B4 receptor activityLeukotriene B4 receptor 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (8)

Processvia Protein(s)Taxonomy
extracellular regionLeukotriene A-4 hydrolaseHomo sapiens (human)
nucleoplasmLeukotriene A-4 hydrolaseHomo sapiens (human)
cytosolLeukotriene A-4 hydrolaseHomo sapiens (human)
extracellular exosomeLeukotriene A-4 hydrolaseHomo sapiens (human)
tertiary granule lumenLeukotriene A-4 hydrolaseHomo sapiens (human)
ficolin-1-rich granule lumenLeukotriene A-4 hydrolaseHomo sapiens (human)
cytosolLeukotriene A-4 hydrolaseHomo sapiens (human)
nucleusLeukotriene A-4 hydrolaseHomo sapiens (human)
plasma membraneLeukotriene B4 receptor 1Homo sapiens (human)
plasma membraneLeukotriene B4 receptor 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID99748In vitro inhibition of recombinant human leukotriene A4 hydrolase.2003Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase.
AID99749Inhibition of leukotriene A4 hydrolase in human recombinant assay2002Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23
Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase.
AID138599Percent inhibition was determined at a dose of 10 mg/Kg in mouse ex vivo assay2000Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4
Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase.
AID223081Inhibitory activity was determined for LTB4 production in human whole blood.2000Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4
Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase.
AID138548Ex vivo inhibition of LTB4 production in mouse whole blood at 10 mg/kg2002Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23
Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase.
AID92873Inhibition of LTB4 production from whole human blood.2003Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase.
AID99747Inhibitory activity was determined against Leukotriene A4 hydrolase2000Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4
Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase.
AID92878Inhibition of leukotriene B4 production in human whole blood2002Bioorganic & medicinal chemistry letters, Dec-02, Volume: 12, Issue:23
Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase.
AID116343Ex vivo inhibition of LTB4 production in mouse whole blood following 10 mg/kg p.o. administration.2003Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's4 (80.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.66 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.66)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]