Page last updated: 2024-12-11

ns 7

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID9800750
CHEMBL ID2401778
SCHEMBL ID562985
MeSH IDM0276683

Synonyms (18)

Synonym
CHEMBL2401778
SCHEMBL562985
pyrimidine, 4-(4-fluorophenyl)-2-methyl-6-((5-(1-piperidinyl)pentyl)oxy)-, hydrochloride (1:1)
ns 7 hydrochloride
enecadin hydrochloride
D9H26GER62 ,
ns-7 hydrochloride
178429-67-9
pyrimidine, 4-(4-fluorophenyl)-2-methyl-6-((5-(1-piperidinyl)pentyl)oxy)-, monohydrochloride
enecadin hydrochloride [who-dd]
ns 7
unii-d9h26ger62
4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy) pyrimidine hydrochloride
ns-7
VLYZLIWXMLUPLD-UHFFFAOYSA-N
4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine hydrochloride
Q27276279
4-(4-fluorophenyl)-2-methyl-6-(5-piperidin-1-ylpentoxy)pyrimidine;hydrochloride

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
") significantly reduced the infarct volume and improved the neuronal dysfunction including the hind leg paralysis, walking disability and motor incoordination, and the deficit of passive avoidance task, although the neuroprotective efficacy was not different among these dosing regimens."( Cerebroprotective action of a Na+/Ca2+ channel blocker NS-7. II. Effect on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of permanent middle cerebral artery occlusion in rats.
Aoki, Y; Itoh, Y; Seto, T; Tamura, M; Ukai, Y, 2001
)
0.31
")) escalating dosing regimen (0."( Decreasing the infusion rate reduces the proarrhythmic risk of NS-7: confirming the relevance of short-term variability of repolarisation in predicting drug-induced torsades de pointes.
Beekman, JD; Detre, E; Petersen, KU; Thomsen, MB; Vos, MA, 2005
)
0.33
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID758085Inhibition of human ERG channel expressed in HEK293 cells at 1 uM by voltage patch clamp technique2013Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14
Synthesis and biological evaluation of pyrrolidine derivatives as novel and potent sodium channel blockers for the treatment of ischemic stroke.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (28)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's8 (28.57)18.2507
2000's18 (64.29)29.6817
2010's1 (3.57)24.3611
2020's1 (3.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 43.09

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index43.09 (24.57)
Research Supply Index3.40 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index119.07 (26.88)
Search Engine Supply Index3.82 (0.95)

This Compound (43.09)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other29 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]