ns-7 has been researched along with Stroke* in 1 studies
1 other study(ies) available for ns-7 and Stroke
| Article | Year |
|---|---|
Synthesis and biological evaluation of pyrrolidine derivatives as novel and potent sodium channel blockers for the treatment of ischemic stroke.
A novel series of pyrrolidine derivatives as Na(+) channel blockers was synthesized and evaluated for their inhibitory effects on neuronal Na(+) channels. Structure-activity relationship (SAR) studies of a pyrrolidine analogue 2 led to the discovery of 5e as a potent Na(+) channel blocker with a low inhibitory action against human ether-a-go-go-related gene (hERG) channels. Compound 5e showed remarkably neuroprotective activity in a rat transient middle cerebral artery occlusion (MCAO) model, suggesting that 5e would act as a neuroprotectant for ischemic stroke. Topics: Animals; Disease Models, Animal; Ether-A-Go-Go Potassium Channels; Humans; Infarction, Middle Cerebral Artery; Neurons; Neuroprotective Agents; Pyrrolidines; Rats; Sodium Channel Blockers; Stroke; Structure-Activity Relationship | 2013 |