Page last updated: 2024-09-28

Diverticula, Esophageal

Saccular protrusion beyond the wall of the ESOPHAGUS.

Synonyms(4)

Synonym
Esophageal Diverticulum
Diverticulum, Esophageal
Esophageal Diverticula
Diverticula, Esophageal

Research Excerpts

Overview

ExcerptReference
"The causation of oesophageal diverticula is controversial; however, the popular current belief is that most occur because of oesophageal dysmotility."( Ismail, F; Khan, N; Van de Werke, IE, 2012)
"esophageal diverticula are classified as 2 types: true diverticula and pseudodiverticula."( Bagheri, R; Ghamari, MJ; Haghi, SZ; Maddah, G; Mashhadi, MR; Sheibani, S; Tavassoli, A, 2014)
"Esophageal diverticulum is a rare condition that requires treatment only when symptoms are present."( Fan, R; Guan, T; Li, Y; Xu, H; Yang, F; Zhou, J, 2023)

Treatment

ExcerptReference
"all patients suffering from symptomatic esophageal diverticulum, who underwent surgical treatment in Ghaem Hospital from 2000 to 2012 and were followed up for at least for one year, were included in the study."( Bagheri, R; Ghamari, MJ; Haghi, SZ; Maddah, G; Mashhadi, MR; Sheibani, S; Tavassoli, A, 2014)

Research

Studies (91)

TimeframeStudies, This Condition (%)All Conditions %
pre-199033 (36.26)23.3326
1990's18 (19.78)12.5806
2000's23 (25.27)18.1394
2010's11 (12.09)28.8240
2020's6 (6.59)9.53
DrugIndicatedRelationship StrengthStudiesTrials
choline0low10
hydrochloric acid0low10
sulfuric acid0low10
acetaminophen0low10
alendronate0low10
fluorouracil0low10
oxybutynin0low10
phenobarbital0low10
thyroxine0low10
prednisone0low10
sucrose0low10
methylene blue0low10
sodium hydroxide0low20
thorium dioxide0low10
enbucrilate0low20
rhenium0low10
technetium0low20
titanium0low10
barium sulfate0low480
iodine0low10
emepronium0low10
itraconazole0low10
fluorodeoxyglucose f180low20
potassium titanylphosphate0low10
technetium tc 99m pentetate0low10
fluorocholine0low10
pulmicort0low10
phenylephrine hydrochloride0low20
morphine0low10
fluticasone0low10
barium0low60
sulfur0low10
amoxicillin-potassium clavulanate combination0low10
indocyanine green0low10
pituitrin0low10
technetium tc 99m sestamibi0low10
sodium pertechnetate tc 99m0low10
technetium tc 99m gluceptate0low10
technetium tc 99m sulfur colloid0low30

Protein Targets (374)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma7007
ATAD5 protein, partial3003
GLS protein3003
Microtubule-associated protein tau3003
Smad32002
aldehyde dehydrogenase 1 family, member A13003
thyroid stimulating hormone receptor2002
nuclear receptor subfamily 1, group I, member 36006
progesterone receptor5005
EWS/FLI fusion protein4004
retinoic acid nuclear receptor alpha variant 16006
retinoid X nuclear receptor alpha5005
estrogen-related nuclear receptor alpha8008
estrogen nuclear receptor alpha9009
peroxisome proliferator activated receptor gamma6006
aryl hydrocarbon receptor4004
chromobox protein homolog 14004
thyroid hormone receptor beta isoform 27007
peripheral myelin protein 224004
cytochrome P450 3A4 isoform 12002
Gamma-aminobutyric acid receptor subunit pi2002
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Solute carrier family 22 member 60101
Carbonic anhydrase 120101
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0101
Voltage-dependent calcium channel gamma-2 subunit5005
Bile salt export pump0606
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 10404
Carbonic anhydrase 20516
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20001
Prostaglandin G/H synthase 10101
Carbonic anhydrase 30101
Cytochrome P450 3A40213
Cytochrome P450 2D60101
Cytochrome P450 2C9 0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-12002
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
UDP-glucuronosyltransferase 1-60001
Glutamate receptor 25005
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0102
Carbonic anhydrase 40404
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60303
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Carbonic anhydrase 5A, mitochondrial0303
Prostaglandin G/H synthase 20001
Carbonic anhydrase 70303
Nuclear receptor ROR-gamma2002
Cytochrome P450 2J20101
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
Carbonic anhydrase 90415
GABA theta subunit2002
Canalicular multispecific organic anion transporter 10404
Carbonic anhydrase 150202
Carbonic anhydrase 130303
Gamma-aminobutyric acid receptor subunit epsilon2002
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0303
toxin B0001
Chain A, farnesyl pyrophosphate synthase0101
Geranylgeranyl pyrophosphate synthase0101
Farnesyl pyrophosphate synthase0202
Acetylcholinesterase0202
Hypoxanthine-guanine phosphoribosyltransferase0101
Farnesyl pyrophosphate synthase 0101
Farnesyl pyrophosphate synthase 0101
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
euchromatic histone-lysine N-methyltransferase 28008
muscarinic acetylcholine receptor M11001
Solute carrier family 22 member 10102
Solute carrier family 22 member 20001
Solute carrier family 22 member 1 0102
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit alpha-41102
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-21102
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Neuronal acetylcholine receptor subunit alpha-50101
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0001
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70101
Solute carrier family 22 member 10102
High affinity choline transporter 10101
Neuronal acetylcholine receptor subunit alpha-100101
Solute carrier family 22 member 20102
ATP-dependent phosphofructokinase4004
thioredoxin reductase4004
Hsf1 protein0011
geminin6006
survival motor neuron protein isoform d4004
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Uracil Phosphoribosyltransferase0101
Luciferase2002
interleukin 81001
endonuclease IV1001
acetylcholinesterase2002
glp-1 receptor, partial4004
Skn7p0001
pregnane X receptor2002
hypoxia-inducible factor 1 alpha subunit3003
TDP1 protein6006
GLI family zinc finger 36006
Thrombopoietin2002
AR protein7007
estrogen receptor 2 (ER beta)5005
nonstructural protein 11001
glucocorticoid receptor [Homo sapiens]5005
farnesoid X nuclear receptor3003
pregnane X nuclear receptor7007
67.9K protein1001
peroxisome proliferator-activated receptor delta4004
arylsulfatase A1001
IDH13003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
v-jun sarcoma virus 17 oncogene homolog (avian)5005
Histone H2A.x2002
peripheral myelin protein 22 isoform 11001
hemoglobin subunit beta1001
nuclear factor erythroid 2-related factor 2 isoform 23003
huntingtin isoform 22002
flap endonuclease 13003
serine/threonine-protein kinase mTOR isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 17007
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
Vpr3003
muscleblind-like protein 1 isoform 12002
lamin isoform A-delta103003
Solute carrier family 22 member 80001
Epidermal growth factor receptor0101
Cellular tumor antigen p537007
Amyloid-beta precursor protein1203
Thymidylate synthase0101
Aromatase0101
ATPase family AAA domain-containing protein 53003
Ataxin-23003
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Carbonic anhydrase 0202
Carbonic anhydrase0202
Carbonic anhydrase0303
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase0202
Fumarate hydratase3003
GALC protein2002
cytochrome P450 family 3 subfamily A polypeptide 45005
G5005
polyprotein3003
activating transcription factor 63003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
heat shock protein beta-12002
Interferon beta5005
HLA class I histocompatibility antigen, B alpha chain 5005
Spike glycoprotein4004
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
Inositol hexakisphosphate kinase 15005
cytochrome P450 2C9, partial5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain E, Fibrin beta chain0101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, 2-oxoglutarate Oxygenase2002
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain1001
T cell receptor, partial1001
luteinizing hormone receptor1001
integrase, partial0101
chaperonin-containing TCP-1 beta subunit homolog1001
lens epithelium-derived growth factor p750101
phosphopantetheinyl transferase1001
Caspase 6, apoptosis-related cysteine peptidase0001
SMAD family member 22002
PPM1D protein1001
SMAD family member 32002
TSHR protein1001
Apoptotic peptidase activating factor 10101
thioredoxin glutathione reductase2002
caspase 7, apoptosis-related cysteine protease1001
hypothetical protein, conserved1001
isocitrate dehydrogenase 1, partial1001
cytochrome P450 2D63003
luciferase1001
bromodomain adjacent to zinc finger domain 2B1001
caspase-31001
thyroid stimulating hormone receptor2002
serine-protein kinase ATM isoform a1001
Bloom syndrome protein isoform 12002
neutrophil cytosol factor 10101
thyroid hormone receptor beta isoform a2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
caspase-9 isoform alpha precursor0101
histone deacetylase 9 isoform 31001
pyruvate kinase PKM isoform a1001
DNA polymerase beta1001
mitogen-activated protein kinase 11001
caspase-3 isoform a preproprotein0101
protein AF-9 isoform a0001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)1001
replicative DNA helicase0001
recombinase A0011
POsterior Segregation0011
DNA repair protein RAD52 homolog isoform a0001
neuropeptide S receptor isoform A1001
Glutathione reductase0101
Glutathione reductase, mitochondrial0102
Glycoprotein hormones alpha chain1001
Albumin0001
Dihydrolipoyl dehydrogenase, mitochondrial0102
Microtubule-associated protein tau0112
Alpha-1B adrenergic receptor0101
Amine oxidase [flavin-containing] A0101
Alpha-1D adrenergic receptor0101
Sodium-dependent noradrenaline transporter 0213
Cruzipain0101
Alpha-synuclein1001
Alpha-1A adrenergic receptor0101
Guanine nucleotide-binding protein G1001
Inositol monophosphatase 11001
TAR DNA-binding protein 431001
Thioredoxin reductase 1, cytoplasmic0102
Dihydrolipoyl dehydrogenase 0102
Zinc finger protein mex-50011
phosphoglycerate kinase1001
Opioid receptor, delta 1b 0101
Acetylcholinesterase0101
Opioid receptor homologue0101
ATP-dependent translocase ABCB10101
Acyl-CoA desaturase 10101
ATP-dependent translocase ABCB10101
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Alpha-2A adrenergic receptor0011
Muscarinic acetylcholine receptor M20202
Translocator protein0011
Histidine decarboxylase0011
ATP-dependent translocase ABCB10101
Proteinase-activated receptor 10112
Sodium-dependent serotonin transporter0202
Delta-type opioid receptor0102
Delta-type opioid receptor0214
Kappa-type opioid receptor0214
Mu-type opioid receptor0317
Kappa-type opioid receptor0214
Mu-type opioid receptor0214
UDP-glucuronosyltransferase 1A30001
Delta-type opioid receptor0214
Kappa-type opioid receptor0202
Kappa-type opioid receptor0214
Mu-type opioid receptor0215
Nociceptin receptor0101
5-hydroxytryptamine receptor 70101
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Potassium voltage-gated channel subfamily H member 20202
Beta-2 adrenergic receptor0101
Mas-related G-protein coupled receptor member X20011
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10303
D(1A) dopamine receptor1001
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20214
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M10203
Muscarinic acetylcholine receptor M30202
Cytochrome P450 2C190101
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 2B0202
Sodium-dependent dopamine transporter 0202
MBT domain-containing protein 10101
Lethal(3)malignant brain tumor-like protein 40101
Muscarinic acetylcholine receptor0011
Lethal(3)malignant brain tumor-like protein 30101
Lethal(3)malignant brain tumor-like protein 10101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
vitamin D3 receptor isoform VDRA1001
nuclear receptor ROR-gamma isoform 12002
Glucocorticoid receptor0426
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Chain A, Beta-lactamase1001
NFKB1 protein, partial1001
glucocerebrosidase1001
nuclear receptor subfamily 1, group I, member 21001
Estrogen receptor0101
Interleukin-50101
Interleukin-50101
Progesterone receptor0101
Glucocorticoid receptor0101
Mineralocorticoid receptor 0112
Matrix metalloproteinase-90101
Androgen receptor0202
Interleukin-5 receptor subunit alpha0101
Estrogen receptor beta0101
Chain A, MALTOPORIN0011
Chain B, MALTOPORIN0011
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
USP1 protein, partial1001
apical membrane antigen 1, AMA11001
serine/threonine-protein kinase PLK11001
DNA polymerase kappa isoform 11001
Solute carrier organic anion transporter family member 1A40001
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50001
Rap guanine nucleotide exchange factor 31001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]