Diverticula, Esophageal

Saccular protrusion beyond the wall of the ESOPHAGUS.

Synonyms(4)

Synonym
Esophageal Diverticulum
Diverticulum, Esophageal
Esophageal Diverticula
Diverticula, Esophageal

Research Excerpts

Overview

Excerpt	Reference
"The causation of oesophageal diverticula is controversial; however, the popular current belief is that most occur because of oesophageal dysmotility."	( Ismail, F; Khan, N; Van de Werke, IE, 2012)
"esophageal diverticula are classified as 2 types: true diverticula and pseudodiverticula."	( Bagheri, R; Ghamari, MJ; Haghi, SZ; Maddah, G; Mashhadi, MR; Sheibani, S; Tavassoli, A, 2014)
"Esophageal diverticulum is a rare condition that requires treatment only when symptoms are present."	( Fan, R; Guan, T; Li, Y; Xu, H; Yang, F; Zhou, J, 2023)

Treatment

Excerpt	Reference
"all patients suffering from symptomatic esophageal diverticulum, who underwent surgical treatment in Ghaem Hospital from 2000 to 2012 and were followed up for at least for one year, were included in the study."	( Bagheri, R; Ghamari, MJ; Haghi, SZ; Maddah, G; Mashhadi, MR; Sheibani, S; Tavassoli, A, 2014)

Research

Studies (91)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	33 (36.26)	23.3326
1990's	18 (19.78)	12.5806
2000's	23 (25.27)	18.1394
2010's	11 (12.09)	28.8240
2020's	6 (6.59)	9.53

Drug	Relationship Strength	Studies
choline	low	1
hydrochloric acid	low	1
sulfuric acid	low	1
acetaminophen	low	1
alendronate	low	1
fluorouracil	low	1
oxybutynin	low	1
phenobarbital	low	1
thyroxine	low	1
prednisone	low	1
sucrose	low	1
methylene blue	low	1
sodium hydroxide	low	2
thorium dioxide	low	1
enbucrilate	low	2
rhenium	low	1
technetium	low	2
titanium	low	1
barium sulfate	low	48
iodine	low	1
emepronium	low	1
itraconazole	low	1
fluorodeoxyglucose f18	low	2
potassium titanylphosphate	low	1
technetium tc 99m pentetate	low	1
fluorocholine	low	1
pulmicort	low	1
phenylephrine hydrochloride	low	2
morphine	low	1
fluticasone	low	1
barium	low	6
sulfur	low	1
amoxicillin-potassium clavulanate combination	low	1
indocyanine green	low	1
pituitrin	low	1
technetium tc 99m sestamibi	low	1
sodium pertechnetate tc 99m	low	1
technetium tc 99m gluceptate	low	1
technetium tc 99m sulfur colloid	low	3

Protein Targets (374)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	7	0	0	7
ATAD5 protein, partial	3	0	0	3
GLS protein	3	0	0	3
Microtubule-associated protein tau	3	0	0	3
Smad3	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
thyroid stimulating hormone receptor	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
progesterone receptor	5	0	0	5
EWS/FLI fusion protein	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
retinoid X nuclear receptor alpha	5	0	0	5
estrogen-related nuclear receptor alpha	8	0	0	8
estrogen nuclear receptor alpha	9	0	0	9
peroxisome proliferator activated receptor gamma	6	0	0	6
aryl hydrocarbon receptor	4	0	0	4
chromobox protein homolog 1	4	0	0	4
thyroid hormone receptor beta isoform 2	7	0	0	7
peripheral myelin protein 22	4	0	0	4
cytochrome P450 3A4 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Bile salt export pump	0	6	0	6
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	4	0	4
Carbonic anhydrase 2	0	5	1	6
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Cytochrome P450 3A4	0	2	1	3
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
UDP-glucuronosyltransferase 1-6	0	0	0	1
Glutamate receptor 2	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	2
Carbonic anhydrase 4	0	4	0	4
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 6	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Carbonic anhydrase 5A, mitochondrial	0	3	0	3
Prostaglandin G/H synthase 2	0	0	0	1
Carbonic anhydrase 7	0	3	0	3
Nuclear receptor ROR-gamma	2	0	0	2
Cytochrome P450 2J2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Carbonic anhydrase 9	0	4	1	5
GABA theta subunit	2	0	0	2
Canalicular multispecific organic anion transporter 1	0	4	0	4
Carbonic anhydrase 15	0	2	0	2
Carbonic anhydrase 13	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	3	0	3
toxin B	0	0	0	1
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Acetylcholinesterase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	8	0	0	8
muscarinic acetylcholine receptor M1	1	0	0	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	1	0	2
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
ATP-dependent phosphofructokinase	4	0	0	4
thioredoxin reductase	4	0	0	4
Hsf1 protein	0	0	1	1
geminin	6	0	0	6
survival motor neuron protein isoform d	4	0	0	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Luciferase	2	0	0	2
interleukin 8	1	0	0	1
endonuclease IV	1	0	0	1
acetylcholinesterase	2	0	0	2
glp-1 receptor, partial	4	0	0	4
Skn7p	0	0	0	1
pregnane X receptor	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
TDP1 protein	6	0	0	6
GLI family zinc finger 3	6	0	0	6
Thrombopoietin	2	0	0	2
AR protein	7	0	0	7
estrogen receptor 2 (ER beta)	5	0	0	5
nonstructural protein 1	1	0	0	1
glucocorticoid receptor [Homo sapiens]	5	0	0	5
farnesoid X nuclear receptor	3	0	0	3
pregnane X nuclear receptor	7	0	0	7
67.9K protein	1	0	0	1
peroxisome proliferator-activated receptor delta	4	0	0	4
arylsulfatase A	1	0	0	1
IDH1	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	2	0	0	2
peripheral myelin protein 22 isoform 1	1	0	0	1
hemoglobin subunit beta	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
huntingtin isoform 2	2	0	0	2
flap endonuclease 1	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	7	0	0	7
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Vpr	3	0	0	3
muscleblind-like protein 1 isoform 1	2	0	0	2
lamin isoform A-delta10	3	0	0	3
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	1	0	1
Cellular tumor antigen p53	7	0	0	7
Amyloid-beta precursor protein	1	2	0	3
Thymidylate synthase	0	1	0	1
Aromatase	0	1	0	1
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	3	0	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	2	0	2
Fumarate hydratase	3	0	0	3
GALC protein	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
G	5	0	0	5
polyprotein	3	0	0	3
activating transcription factor 6	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
heat shock protein beta-1	2	0	0	2
Interferon beta	5	0	0	5
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Spike glycoprotein	4	0	0	4
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Inositol hexakisphosphate kinase 1	5	0	0	5
cytochrome P450 2C9, partial	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain E, Fibrin beta chain	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
lens epithelium-derived growth factor p75	0	1	0	1
phosphopantetheinyl transferase	1	0	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
SMAD family member 2	2	0	0	2
PPM1D protein	1	0	0	1
SMAD family member 3	2	0	0	2
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
thioredoxin glutathione reductase	2	0	0	2
caspase 7, apoptosis-related cysteine protease	1	0	0	1
hypothetical protein, conserved	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
cytochrome P450 2D6	3	0	0	3
luciferase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
caspase-3	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
serine-protein kinase ATM isoform a	1	0	0	1
Bloom syndrome protein isoform 1	2	0	0	2
neutrophil cytosol factor 1	0	1	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
caspase-9 isoform alpha precursor	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
DNA polymerase beta	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	1	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Albumin	0	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	1	3
Cruzipain	0	1	0	1
Alpha-synuclein	1	0	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Inositol monophosphatase 1	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	1	0	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	0	1	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Translocator protein	0	0	1	1
Histidine decarboxylase	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	2	0	2
Delta-type opioid receptor	0	1	0	2
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	3	1	7
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
D(1A) dopamine receptor	1	0	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	1	4
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	3
Muscarinic acetylcholine receptor M3	0	2	0	2
Cytochrome P450 2C19	0	1	0	1
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Muscarinic acetylcholine receptor	0	0	1	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
vitamin D3 receptor isoform VDRA	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
Glucocorticoid receptor	0	4	2	6
Glycine receptor subunit alpha-1	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Chain A, Beta-lactamase	1	0	0	1
NFKB1 protein, partial	1	0	0	1
glucocerebrosidase	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Estrogen receptor	0	1	0	1
Interleukin-5	0	1	0	1
Interleukin-5	0	1	0	1
Progesterone receptor	0	1	0	1
Glucocorticoid receptor	0	1	0	1
Mineralocorticoid receptor	0	1	1	2
Matrix metalloproteinase-9	0	1	0	1
Androgen receptor	0	2	0	2
Interleukin-5 receptor subunit alpha	0	1	0	1
Estrogen receptor beta	0	1	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
USP1 protein, partial	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Diverticula, Esophageal

Synonyms(4)

Research Excerpts

Overview

Treatment

Research

Studies (91)

Drugs Studied (46)

Protein Targets (374)