fluorocholine and Pinealoma

The efficacy of hybrid 18F-Fluroethyl-Choline (FEC) positron emission tomography (PET)/magnetic resonance imaging (MRI) was investigated as an imaging modality for diagnosis and assessment of treatment response and remission status in four patients with proven or suspected intracranial non-germinomatous germ cell tumours (NGGCT). In two patients faint or absent choline avidity correlated with negative histology, whereas in other two patients, persistent choline avidity in the residual mass was suggestive of presence of viable tumour, subsequently confirmed histologically. We conclude that FEC-PET/MRI may be an effective imaging tool in detecting viable residual tumour in patients with intracranial NGGCT post treatment.

Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain Neoplasms; Cerebral Ventricle Neoplasms; Choline; Combined Modality Therapy; Cranial Irradiation; Craniotomy; Female; Fluorine Radioisotopes; Humans; Magnetic Resonance Imaging; Male; Multimodal Imaging; Neoplasms, Germ Cell and Embryonal; Neuroimaging; Pineal Gland; Pinealoma; Positron-Emission Tomography; Radiopharmaceuticals; Young Adult