Page last updated: 2024-09-28

Sadism

A condition in which there is a derivation of pleasure from inflicting pain, discomfort or humiliation on another person or persons. The sexual significance of sadistic wishes or behavior may be conscious or unconscious.

Synonyms(2)

Synonym
Sexual Sadism
Sadism

Research Excerpts

Research

Studies (80)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	52 (65.00)	23.3326
1990's	6 (7.50)	12.5806
2000's	13 (16.25)	18.1394
2010's	8 (10.00)	28.8240
2020's	1 (1.25)	9.53

Drug	Relationship Strength	Studies
3,4-methylenedioxyamphetamine	low	12
methadone	low	1
medroxyprogesterone acetate	low	2
isoprene	low	1
cyproterone acetate	low	4
medroxyprogesterone	low	4
s,n,n'-tripropylthiocarbamate	low	1
4-methoxyamphetamine	low	7
fomesafen	low	1
melamine phosphate	low	4
oxytocin	low	1
leuprolide	low	1
cyproterone	low	5
naltrexone	low	1
id	low	2
sodium ethylxanthate	low	10
ego	low	30

Protein Targets (204)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
5-hydroxytryptamine receptor 2C	0	2	2	4
5-hydroxytryptamine receptor 2A	0	2	2	4
5-hydroxytryptamine receptor 1A	0	1	2	3
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium-dependent dopamine transporter	0	0	1	1
5-hydroxytryptamine receptor 1B	0	2	2	4
5-hydroxytryptamine receptor 1D	0	1	2	3
5-hydroxytryptamine receptor 1F	0	1	2	3
5-hydroxytryptamine receptor 2B	0	2	2	4
5-hydroxytryptamine receptor 6	0	0	2	2
Sodium-dependent serotonin transporter	0	2	2	4
Sodium-dependent serotonin transporter	0	2	1	3
5-hydroxytryptamine receptor 7	0	0	2	2
5-hydroxytryptamine receptor 5A	0	0	2	2
5-hydroxytryptamine receptor 5B	0	0	2	2
5-hydroxytryptamine receptor 3A	0	0	2	2
Sodium-dependent dopamine transporter	0	2	0	2
5-hydroxytryptamine receptor 4	0	0	2	2
5-hydroxytryptamine receptor 3B	0	0	2	2
TDP1 protein	4	0	0	4
AR protein	7	0	0	7
glucocorticoid receptor [Homo sapiens]	6	0	0	6
estrogen nuclear receptor alpha	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
Chain A, Beta-lactamase	3	0	0	3
Chain A, Cruzipain	2	0	0	2
thioredoxin reductase	1	0	0	1
pregnane X receptor	2	0	0	2
RAR-related orphan receptor gamma	5	0	0	5
SMAD family member 2	3	0	0	3
ATAD5 protein, partial	2	0	0	2
USP1 protein, partial	1	0	0	1
SMAD family member 3	3	0	0	3
GLI family zinc finger 3	4	0	0	4
Smad3	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
thyroid stimulating hormone receptor	2	0	0	2
estrogen receptor 2 (ER beta)	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	4	0	0	4
progesterone receptor	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
retinoic acid nuclear receptor alpha variant 1	5	0	0	5
retinoid X nuclear receptor alpha	4	0	0	4
estrogen-related nuclear receptor alpha	6	0	0	6
farnesoid X nuclear receptor	3	0	0	3
pregnane X nuclear receptor	5	0	0	5
G	3	0	0	3
67.9K protein	1	0	0	1
peroxisome proliferator-activated receptor delta	3	0	0	3
peroxisome proliferator activated receptor gamma	5	0	0	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
aryl hydrocarbon receptor	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
activating transcription factor 6	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
D(1A) dopamine receptor	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
thyroid hormone receptor beta isoform 2	4	0	0	4
heat shock protein beta-1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
geminin	2	0	0	2
peripheral myelin protein 22	1	0	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
lamin isoform A-delta10	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Interferon beta	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Glucocorticoid receptor	0	6	1	7
Cellular tumor antigen p53	2	0	0	2
Progesterone receptor	0	3	1	4
Glycine receptor subunit alpha-1	0	6	0	6
Androgen receptor	0	4	2	6
Androgen receptor	0	6	0	6
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Glycine receptor subunit alpha-3	0	6	0	6
Adenosine receptor A1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Adenosine receptor A2b	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Adenosine receptor A2a	0	1	0	1
Mu-type opioid receptor	0	6	2	10
Nuclear receptor ROR-gamma	2	0	0	2
Spike glycoprotein	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
GABA theta subunit	2	0	0	2
Inositol hexakisphosphate kinase 1	3	0	0	3
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
cytochrome P450 2C9, partial	3	0	0	3
ORF73	0	0	1	1
Luciferase	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
Histone H2A.x	2	0	0	2
interleukin 8	2	0	0	2
cellular tumor antigen p53 isoform a	1	0	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Gonadotropin-releasing hormone receptor	0	1	0	1
Gonadotropin-releasing hormone receptor	0	2	0	2
GALC protein	1	0	0	1
Microtubule-associated protein tau	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
PINK1	2	0	0	2
Parkin	2	0	0	2
chromobox protein homolog 1	1	0	0	1
Cytochrome P450 2C19	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
nonstructural protein 1	1	0	0	1
IDH1	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
ATP-binding cassette sub-family C member 3	0	1	0	1
Multidrug resistance-associated protein 4	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Bile salt export pump	0	2	0	2
Estrogen receptor	0	1	1	2
Sex hormone-binding globulin	0	0	1	1
Mineralocorticoid receptor	0	1	0	1
Androgen receptor	0	0	1	1
Glutamate receptor 2	1	0	0	1
Histamine H2 receptor	0	2	0	2
Alpha-synuclein	1	0	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Estrogen receptor beta	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
D(4) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	3	2	7
Kappa-type opioid receptor	0	3	1	7
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Aldehyde oxidase 1	0	1	0	1
survival motor neuron protein isoform d	1	0	0	1
5-hydroxytryptamine receptor 3E	0	1	0	1
cytochrome P450 2D6	1	0	0	1
Solute carrier family 22 member 1	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Cytochrome P450 2D6	0	1	0	2
Histidine decarboxylase	0	0	1	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Delta-type opioid receptor	0	2	1	4
Delta-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	2	1	3
Mu-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	2	0	3
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	2	1	4
5-hydroxytryptamine receptor 3A	0	1	0	1
Mu-type opioid receptor	0	2	1	4
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase	0	1	0	1
Sodium/iodide cotransporter	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1a receptor	0	2	1	3
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]