Page last updated: 2024-09-28

Sadism

A condition in which there is a derivation of pleasure from inflicting pain, discomfort or humiliation on another person or persons. The sexual significance of sadistic wishes or behavior may be conscious or unconscious.

Synonyms(2)

Synonym
Sexual Sadism
Sadism

Research Excerpts

Research

Studies (80)

TimeframeStudies, This Condition (%)All Conditions %
pre-199052 (65.00)23.3326
1990's6 (7.50)12.5806
2000's13 (16.25)18.1394
2010's8 (10.00)28.8240
2020's1 (1.25)9.53
DrugIndicatedRelationship StrengthStudiesTrials
3,4-methylenedioxyamphetamine0low120
methadone0low10
medroxyprogesterone acetate0low20
isoprene0low10
cyproterone acetate0low40
medroxyprogesterone0low40
s,n,n'-tripropylthiocarbamate0low10
4-methoxyamphetamine0low70
fomesafen0low10
melamine phosphate0low40
oxytocin0low10
leuprolide0low10
cyproterone0low50
naltrexone0low10
id0low20
sodium ethylxanthate0low100
ego0low300

Protein Targets (204)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
5-hydroxytryptamine receptor 2C0224
5-hydroxytryptamine receptor 2A0224
5-hydroxytryptamine receptor 1A0123
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0011
5-hydroxytryptamine receptor 1B0224
5-hydroxytryptamine receptor 1D0123
5-hydroxytryptamine receptor 1F0123
5-hydroxytryptamine receptor 2B0224
5-hydroxytryptamine receptor 60022
Sodium-dependent serotonin transporter0224
Sodium-dependent serotonin transporter0213
5-hydroxytryptamine receptor 7 0022
5-hydroxytryptamine receptor 5A0022
5-hydroxytryptamine receptor 5B0022
5-hydroxytryptamine receptor 3A0022
Sodium-dependent dopamine transporter 0202
5-hydroxytryptamine receptor 4 0022
5-hydroxytryptamine receptor 3B0022
TDP1 protein4004
AR protein7007
glucocorticoid receptor [Homo sapiens]6006
estrogen nuclear receptor alpha8008
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
nuclear receptor subfamily 1, group I, member 23003
Chain A, Beta-lactamase3003
Chain A, Cruzipain2002
thioredoxin reductase1001
pregnane X receptor2002
RAR-related orphan receptor gamma5005
SMAD family member 23003
ATAD5 protein, partial2002
USP1 protein, partial1001
SMAD family member 33003
GLI family zinc finger 34004
Smad31001
aldehyde dehydrogenase 1 family, member A13003
thyroid stimulating hormone receptor2002
estrogen receptor 2 (ER beta)2002
nuclear receptor subfamily 1, group I, member 34004
progesterone receptor5005
cytochrome P450 family 3 subfamily A polypeptide 42002
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha4004
estrogen-related nuclear receptor alpha6006
farnesoid X nuclear receptor3003
pregnane X nuclear receptor5005
G3003
67.9K protein1001
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
aryl hydrocarbon receptor2002
thyroid stimulating hormone receptor2002
activating transcription factor 61001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
D(1A) dopamine receptor1001
vitamin D3 receptor isoform VDRA1001
nuclear factor erythroid 2-related factor 2 isoform 22002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
thyroid hormone receptor beta isoform 24004
heat shock protein beta-12002
nuclear factor erythroid 2-related factor 2 isoform 16006
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
nuclear receptor ROR-gamma isoform 11001
geminin2002
peripheral myelin protein 221001
cytochrome P450 3A4 isoform 12002
lamin isoform A-delta103003
Gamma-aminobutyric acid receptor subunit pi2002
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Glucocorticoid receptor0617
Cellular tumor antigen p532002
Progesterone receptor0314
Glycine receptor subunit alpha-10606
Androgen receptor0426
Androgen receptor0606
Gamma-aminobutyric acid receptor subunit beta-12002
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Glycine receptor subunit alpha-30606
Adenosine receptor A10202
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Adenosine receptor A2b0101
Gamma-aminobutyric acid receptor subunit alpha-62002
Adenosine receptor A2a0101
Mu-type opioid receptor06210
Nuclear receptor ROR-gamma2002
Spike glycoprotein3003
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
GABA theta subunit2002
Inositol hexakisphosphate kinase 13003
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Gamma-aminobutyric acid receptor subunit epsilon2002
cytochrome P450 2C9, partial3003
ORF730011
Luciferase2002
hypoxia-inducible factor 1 alpha subunit2002
Histone H2A.x2002
interleukin 82002
cellular tumor antigen p53 isoform a1001
Integrin beta-31001
Integrin alpha-IIb1001
Gonadotropin-releasing hormone receptor0101
Gonadotropin-releasing hormone receptor0202
GALC protein1001
Microtubule-associated protein tau1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
PINK12002
Parkin2002
chromobox protein homolog 11001
Cytochrome P450 2C190101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
nonstructural protein 11001
IDH11001
euchromatic histone-lysine N-methyltransferase 21001
transcriptional regulator ERG isoform 31001
DNA polymerase iota isoform a (long)1001
neuropeptide S receptor isoform A1001
ATP-binding cassette sub-family C member 30101
Multidrug resistance-associated protein 40101
Voltage-dependent calcium channel gamma-2 subunit1001
Bile salt export pump0202
Estrogen receptor0112
Sex hormone-binding globulin0011
Mineralocorticoid receptor 0101
Androgen receptor0011
Glutamate receptor 21001
Histamine H2 receptor0202
Alpha-synuclein1001
Aldo-keto reductase family 1 member C30101
Aldo-keto reductase family 1 member C2 0101
Guanine nucleotide-binding protein G1001
Aldo-keto reductase family 1 member C10101
Estrogen receptor beta0112
Canalicular multispecific organic anion transporter 10101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
ATP-dependent translocase ABCB10101
D(2) dopamine receptor0101
Cytochrome P450 2B60101
D(4) dopamine receptor0101
D(3) dopamine receptor0101
Delta-type opioid receptor0327
Kappa-type opioid receptor0317
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Potassium voltage-gated channel subfamily H member 20202
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Mas-related G-protein coupled receptor member X20011
Aldehyde oxidase 1 0101
survival motor neuron protein isoform d1001
5-hydroxytryptamine receptor 3E0101
cytochrome P450 2D61001
Solute carrier family 22 member 1 0101
5-hydroxytryptamine receptor 3B0101
Cytochrome P450 2D60102
Histidine decarboxylase0011
UDP-glucuronosyltransferase 1A1 0001
Delta-type opioid receptor0214
Delta-type opioid receptor0213
Kappa-type opioid receptor0213
Mu-type opioid receptor0213
Kappa-type opioid receptor0213
Kappa-type opioid receptor0203
Nociceptin receptor0101
Mu-type opioid receptor0214
5-hydroxytryptamine receptor 3A0101
Mu-type opioid receptor0214
5-hydroxytryptamine receptor 3D0101
5-hydroxytryptamine receptor 3C0101
UDP-glucuronosyltransferase 1A80001
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 40101
Carbonic anhydrase0101
Sodium/iodide cotransporter0101
Carbonic anhydrase 150101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Vasopressin V2 receptor0112
Oxytocin receptor0224
Vasopressin V1a receptor0101
Vasopressin V1a receptor0213
Vasopressin V1b receptor0112
Vasopressin V1b receptor0101
Oxytocin receptor0101
Oxytocin receptor0011
Vasopressin V2 receptor 0101
thyroid hormone receptor beta isoform a1001
Caspase-71001
caspase-31001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]