| Protein | Potency Measurements | Inhibition Measurements | Activation Measurements | Drugs |
|---|
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | 1 | 0 | 0 | 1 |
| thioredoxin reductase | 4 | 0 | 0 | 4 |
| GALC protein | 2 | 0 | 0 | 2 |
| EWS/FLI fusion protein | 2 | 0 | 0 | 2 |
| cytochrome P450 2D6 | 1 | 0 | 0 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | 4 | 0 | 0 | 4 |
| Bloom syndrome protein isoform 1 | 3 | 0 | 0 | 3 |
| cytochrome P450 2D6 isoform 1 | 2 | 0 | 0 | 2 |
| peripheral myelin protein 22 isoform 1 | 2 | 0 | 0 | 2 |
| D(1A) dopamine receptor | 2 | 0 | 0 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | 1 | 0 | 0 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | 1 | 0 | 0 | 1 |
| mitogen-activated protein kinase 1 | 1 | 0 | 0 | 1 |
| geminin | 3 | 0 | 0 | 3 |
| muscarinic acetylcholine receptor M1 | 2 | 0 | 0 | 2 |
| Bile salt export pump | 0 | 3 | 0 | 3 |
| Sodium channel protein type 1 subunit alpha | 0 | 1 | 0 | 1 |
| Sodium channel protein type 2 subunit alpha | 0 | 1 | 0 | 1 |
| Sodium channel protein type 3 subunit alpha | 0 | 1 | 0 | 1 |
| Dihydrofolate reductase | 0 | 2 | 0 | 2 |
| Potassium voltage-gated channel subfamily E member 1 | 0 | 1 | 0 | 1 |
| Sodium channel protein type 4 subunit alpha | 0 | 1 | 0 | 2 |
| Potassium voltage-gated channel subfamily KQT member 1 | 0 | 1 | 0 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | 0 | 2 | 0 | 2 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | 0 | 2 | 0 | 2 |
| Sodium channel protein type 5 subunit alpha | 0 | 2 | 0 | 2 |
| Sodium channel protein type 9 subunit alpha | 0 | 1 | 0 | 1 |
| Sodium channel protein type 2 subunit alpha | 0 | 1 | 0 | 1 |
| Sodium channel protein type 3 subunit alpha | 0 | 1 | 0 | 1 |
| Sigma non-opioid intracellular receptor 1 | 0 | 1 | 0 | 1 |
| Sodium channel protein type 10 subunit alpha | 0 | 1 | 0 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | 1 | 0 | 0 | 1 |
| Chain A, HADH2 protein | 1 | 0 | 0 | 1 |
| Chain B, HADH2 protein | 1 | 0 | 0 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | 2 | 0 | 0 | 2 |
| interleukin 8 | 1 | 0 | 0 | 1 |
| ClpP | 1 | 0 | 0 | 1 |
| phosphopantetheinyl transferase | 1 | 0 | 0 | 1 |
| RAR-related orphan receptor gamma | 2 | 0 | 0 | 2 |
| ATAD5 protein, partial | 1 | 0 | 0 | 1 |
| GLI family zinc finger 3 | 2 | 0 | 0 | 2 |
| AR protein | 2 | 0 | 0 | 2 |
| caspase 7, apoptosis-related cysteine protease | 1 | 0 | 0 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | 1 | 0 | 0 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | 1 | 0 | 0 | 1 |
| regulator of G-protein signaling 4 | 1 | 0 | 0 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | 1 | 0 | 0 | 1 |
| pregnane X nuclear receptor | 1 | 0 | 0 | 1 |
| estrogen nuclear receptor alpha | 2 | 0 | 0 | 2 |
| caspase-3 | 1 | 0 | 0 | 1 |
| aryl hydrocarbon receptor | 1 | 0 | 0 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | 1 | 0 | 0 | 1 |
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | 1 | 0 | 0 | 1 |
| chromobox protein homolog 1 | 2 | 0 | 0 | 2 |
| ras-related protein Rab-9A | 1 | 0 | 0 | 1 |
| cytochrome P450 3A4 isoform 1 | 1 | 0 | 0 | 1 |
| M-phase phosphoprotein 8 | 1 | 0 | 0 | 1 |
| lamin isoform A-delta10 | 2 | 0 | 0 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | 1 | 1 | 1 | 3 |
| ATP-binding cassette sub-family C member 3 | 0 | 2 | 0 | 2 |
| Multidrug resistance-associated protein 4 | 0 | 2 | 0 | 2 |
| Cellular tumor antigen p53 | 2 | 0 | 0 | 2 |
| Cytochrome P450 1A1 | 0 | 1 | 0 | 1 |
| Cytochrome P450 1A2 | 0 | 1 | 0 | 1 |
| Myeloperoxidase | 0 | 1 | 0 | 1 |
| Cytochrome P450 1A2 | 0 | 2 | 0 | 2 |
| Cholinesterase | 0 | 1 | 0 | 1 |
| Cytochrome P450 2C11 | 0 | 1 | 0 | 1 |
| Cytochrome P450 2D6 | 0 | 2 | 0 | 2 |
| Aromatase | 0 | 1 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | 1 | 1 | 1 | 3 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | 0 | 2 | 0 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | 1 | 1 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | 1 | 1 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | 1 | 1 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | 1 | 1 | 1 | 3 |
| Acetylcholinesterase | 0 | 1 | 0 | 1 |
| Metabotropic glutamate receptor 1 | 0 | 1 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | 1 | 1 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | 1 | 1 | 1 | 3 |
| Acetylcholinesterase | 0 | 1 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | 1 | 1 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | 1 | 1 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | 1 | 1 | 1 | 3 |
| Mu-type opioid receptor | 0 | 1 | 0 | 1 |
| Nociceptin receptor | 0 | 1 | 0 | 1 |
| Alpha-1A adrenergic receptor | 0 | 2 | 1 | 3 |
| Melatonin receptor type 1A | 0 | 2 | 1 | 3 |
| Melatonin receptor type 1C | 0 | 0 | 1 | 1 |
| Melatonin receptor type 1A | 0 | 1 | 1 | 2 |
| Melatonin receptor type 1B | 0 | 2 | 1 | 3 |
| Melatonin receptor type 1C | 0 | 1 | 1 | 2 |
| Melatonin receptor type 1B | 0 | 1 | 1 | 2 |
| Nuclear receptor ROR-gamma | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | 1 | 1 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | 1 | 1 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | 1 | 1 | 1 | 3 |
| Nuclear factor erythroid 2-related factor 2 | 0 | 0 | 0 | 1 |
| Cytochrome P450 1B1 | 0 | 1 | 0 | 1 |
| Palmitoleoyl-protein carboxylesterase NOTUM | 0 | 1 | 0 | 1 |
| GABA theta subunit | 1 | 1 | 1 | 3 |
| Canalicular multispecific organic anion transporter 1 | 0 | 2 | 0 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | 1 | 1 | 1 | 3 |
| Carboxylic ester hydrolase | 0 | 1 | 0 | 1 |
| Histamine H3 receptor | 0 | 1 | 0 | 1 |
| ATP-dependent phosphofructokinase | 1 | 0 | 0 | 1 |
| glp-1 receptor, partial | 1 | 0 | 0 | 1 |
| TDP1 protein | 2 | 0 | 0 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 1 | 0 | 0 | 1 |
| glucocorticoid receptor [Homo sapiens] | 1 | 0 | 0 | 1 |
| estrogen-related nuclear receptor alpha | 1 | 0 | 0 | 1 |
| peroxisome proliferator activated receptor gamma | 1 | 0 | 0 | 1 |
| IDH1 | 1 | 0 | 0 | 1 |
| thyroid stimulating hormone receptor | 1 | 0 | 0 | 1 |
| beta-2 adrenergic receptor | 1 | 0 | 0 | 1 |
| lysosomal alpha-glucosidase preproprotein | 1 | 0 | 0 | 1 |
| mu-type opioid receptor isoform MOR-1 | 0 | 0 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | 1 | 0 | 0 | 1 |
| Vpr | 1 | 0 | 0 | 1 |
| peripheral myelin protein 22 | 1 | 0 | 0 | 1 |
| 5-hydroxytryptamine receptor 2A | 0 | 0 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | 1 | 0 | 0 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | 1 | 0 | 0 | 1 |
| Spike glycoprotein | 1 | 0 | 0 | 1 |
| Beta-1 adrenergic receptor | 0 | 1 | 1 | 3 |
| arylsulfatase A | 1 | 0 | 0 | 1 |
| Solute carrier family 22 member 1 | 0 | 1 | 0 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | 0 | 1 | 0 | 1 |
| Bile salt export pump | 0 | 1 | 0 | 1 |
| 5-hydroxytryptamine receptor 4 | 0 | 2 | 0 | 2 |
| Albumin | 0 | 0 | 1 | 1 |
| Beta-2 adrenergic receptor | 0 | 2 | 1 | 3 |
| Muscarinic acetylcholine receptor M2 | 0 | 1 | 1 | 2 |
| ATP-dependent translocase ABCB1 | 0 | 2 | 0 | 2 |
| Beta-1 adrenergic receptor | 0 | 2 | 1 | 3 |
| Cytochrome P450 3A4 | 0 | 1 | 0 | 1 |
| 5-hydroxytryptamine receptor 1A | 0 | 1 | 0 | 1 |
| Alpha-2A adrenergic receptor | 0 | 1 | 2 | 4 |
| Adenosine receptor A3 | 0 | 1 | 1 | 2 |
| Beta-2 adrenergic receptor | 0 | 2 | 0 | 3 |
| Cytochrome P450 2C8 | 0 | 1 | 0 | 1 |
| Muscarinic acetylcholine receptor M1 | 0 | 1 | 1 | 2 |
| Cytochrome P450 2C9 | 0 | 1 | 0 | 1 |
| Beta-3 adrenergic receptor | 0 | 2 | 1 | 3 |
| D(2) dopamine receptor | 0 | 1 | 1 | 2 |
| Alpha-1B adrenergic receptor | 0 | 1 | 1 | 2 |
| Alpha-2B adrenergic receptor | 0 | 0 | 1 | 2 |
| Beta-1 adrenergic receptor | 0 | 2 | 1 | 4 |
| Alpha-2C adrenergic receptor | 0 | 1 | 2 | 4 |
| D(3) dopamine receptor | 0 | 1 | 0 | 1 |
| 5-hydroxytryptamine receptor 1A | 0 | 2 | 1 | 4 |
| Alpha-2B adrenergic receptor | 0 | 0 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | 0 | 1 | 1 | 2 |
| D(1A) dopamine receptor | 0 | 1 | 1 | 2 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | 0 | 1 | 0 | 1 |
| Alpha-2C adrenergic receptor | 0 | 0 | 1 | 1 |
| Alpha-2A adrenergic receptor | 0 | 0 | 1 | 1 |
| Alpha-1D adrenergic receptor | 0 | 1 | 1 | 2 |
| Alpha-1D adrenergic receptor | 0 | 0 | 1 | 2 |
| Endothelin-1 receptor | 0 | 1 | 1 | 2 |
| Beta-3 adrenergic receptor | 0 | 2 | 0 | 2 |
| 5-hydroxytryptamine receptor 1B | 0 | 2 | 1 | 3 |
| 5-hydroxytryptamine receptor 2A | 0 | 2 | 1 | 3 |
| 5-hydroxytryptamine receptor 2C | 0 | 2 | 1 | 3 |
| 5-hydroxytryptamine receptor 1B | 0 | 2 | 0 | 2 |
| Adenosine receptor A2a | 0 | 1 | 1 | 2 |
| Neuromedin-K receptor | 0 | 0 | 1 | 1 |
| Type-1 angiotensin II receptor | 0 | 1 | 1 | 2 |
| Sodium-dependent serotonin transporter | 0 | 2 | 0 | 2 |
| Cholecystokinin receptor type A | 0 | 1 | 1 | 2 |
| Cytochrome P450 2C19 | 0 | 1 | 0 | 1 |
| 5-hydroxytryptamine receptor 7 | 0 | 1 | 1 | 2 |
| Beta-1 adrenergic receptor | 0 | 1 | 0 | 1 |
| Alpha-1A adrenergic receptor | 0 | 1 | 2 | 4 |
| Alpha-1B adrenergic receptor | 0 | 0 | 1 | 2 |
| Mu-type opioid receptor | 0 | 1 | 1 | 2 |
| Vasopressin V1a receptor | 0 | 1 | 1 | 2 |
| Delta-type opioid receptor | 0 | 1 | 1 | 2 |
| Kappa-type opioid receptor | 0 | 1 | 1 | 2 |
| 5-hydroxytryptamine receptor 2B | 0 | 2 | 1 | 3 |
| 5-hydroxytryptamine receptor 6 | 0 | 2 | 1 | 3 |
| 5-hydroxytryptamine receptor 7 | 0 | 1 | 0 | 1 |
| Cytochrome P450 2J2 | 0 | 1 | 0 | 1 |
| Beta-2 adrenergic receptor | 0 | 1 | 0 | 1 |
| Sodium/bile acid cotransporter | 0 | 1 | 0 | 1 |
| Beta-2 adrenergic receptor | 0 | 1 | 1 | 3 |
| Ataxin-2 | 1 | 0 | 0 | 1 |
| Sigma non-opioid intracellular receptor 1 | 0 | 2 | 0 | 2 |
| Nuclear receptor subfamily 2 group E member 1 | 0 | 0 | 2 | 2 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |