Compounds > nsc 38280
Page last updated: 2024-12-06

nsc 38280

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID65558
CHEMBL ID1448793
MeSH IDM0045730

Synonyms (39)

Synonym
wander
nsc-60339
nsc 60339
nsc60339
mls000737368 ,
hr 2198
1, 2-chloro-n,n'-bis[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]-
70-09-7
1,4-benzenedicarboxamide, {2-chloro-n,n'-bis[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]-}
2-chloro-n~1~,n~4~-bis(4-(4,5-dihydro-1h-imidazol-2-yl)phenyl)terephthalamide
terephthalanilide, 2-chloro-4', 4''-di-2-imidazolin-2-yl-
2-chloro-n1,n4-bis[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]terephthalamide
smr000528281
2-chloro-1-n,4-n-bis[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]benzene-1,4-dicarboxamide
NCGC00246844-01
1,4-benzenedicarboxamide, 2-chloro-n,n'-bis(4-(4,5-dihydro-1h-imidazol-2-yl)phenyl)-
unii-wdg983w63e
2-chloro-4',4''-di-2-imidazolin-2-yl-terephthalanilide
terephthalanilide, 2-chloro-4',4''-di-2-imidazolin-2-yl-
wdg983w63e ,
CHEMBL1448793
cid_65558
2-chloro-n1,n4-bis[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]benzene-1,4-dicarboxamide
2-chloro-n,n''-bis[4-(2-imidazolin-2-yl)phenyl]terephthalamide
2-chloranyl-n1,n4-bis[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]benzene-1,4-dicarboxamide
2-chloro-n,n''''''''-bis[4-(2-imidazolin-2-yl)phenyl]terephthalamide
2-chloro-n,n''''-bis[4-(2-imidazolin-2-yl)phenyl]terephthalamide
bdbm43864
glycopeptide, 3b
4',4''-bis(2-imidazolin-2-yl)-2-chloroterephthalanilide
1,4-benzenedicarboxamide, 2-chloro-n1,n4-bis(4-(4,5-dihydro-1h-imidazol-2-yl)phenyl)-
E75289
2-chloro-n~1~,n~4~-bis[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]benzene-1,4-dicarboxamide
DTXSID50990240
HY-119172
BS-46384
CS-0069366
2-chloro-n1,n4-bis(4-(4,5-dihydro-1h-imidazol-2-yl)phenyl)terephthalamide
AKOS040742314
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (26)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency56.23410.631035.7641100.0000AID504339
WRNHomo sapiens (human)Potency100.00000.168331.2583100.0000AID651768
TDP1 proteinHomo sapiens (human)Potency6.24060.000811.382244.6684AID686978; AID686979
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency2.81840.011212.4002100.0000AID1030
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency0.79430.28189.721235.4813AID2326
glucocerebrosidaseHomo sapiens (human)Potency25.11890.01268.156944.6684AID2101
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency25.11890.035520.977089.1251AID504332
chromobox protein homolog 1Homo sapiens (human)Potency70.79460.006026.168889.1251AID540317
importin subunit beta-1 isoform 1Homo sapiens (human)Potency100.00005.804836.130665.1308AID540263
DNA polymerase betaHomo sapiens (human)Potency0.89130.022421.010289.1251AID485314
flap endonuclease 1Homo sapiens (human)Potency50.11870.133725.412989.1251AID588795
eyes absent homolog 2 isoform aHomo sapiens (human)Potency100.00001.199814.641950.1187AID488837
snurportin-1Homo sapiens (human)Potency100.00005.804836.130665.1308AID540263
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency39.81070.010323.856763.0957AID2662
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency10.00000.050127.073689.1251AID588590
DNA polymerase kappa isoform 1Homo sapiens (human)Potency56.23410.031622.3146100.0000AID588579
VprHuman immunodeficiency virus 1Potency3.16231.584919.626463.0957AID651644
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency30.13130.060110.745337.9330AID485367
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
SUMO-1Homo sapiens (human)IC50 (µMol)35.60500.64707.494715.9000AID624382; AID624383
RAD51Homo sapiens (human)IC50 (µMol)22.57001.399017.721432.1000AID1436; AID1437
ubiquitin-conjugating enzyme E2 NHomo sapiens (human)IC50 (µMol)2.51250.873010.721978.4000AID493155; AID493182
bcl-2-related protein A1Mus musculus (house mouse)IC50 (µMol)9.71000.41907.756335.1000AID504689
rac GTPase-activating protein 1 isoform aHomo sapiens (human)IC50 (µMol)35.80007.390057.8904301.2400AID624330
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1Saccharomyces cerevisiae S288CKi4.00000.04101.36774.0000AID1799481
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
DNA repair and recombination protein RAD54-like isoform 1Homo sapiens (human)AC5013.78000.814019.311978.9500AID651657
HSP40, subfamily A [Plasmodium falciparum 3D7]Plasmodium falciparum 3D7AbsAC1000_uM4.17400.12904.116911.3160AID540271
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (30)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID658164Stabilization of human G-quadruplex F21T assessed as change in melting temperature at 5 uM by FRET assay2012Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries.
AID1445785Antimicrobial activity against Escherichia coli BW25113 after 24 hrs by two-fold broth microdilution assay2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.
AID1445789Inhibition of AcrA efflux pump in Escherichia coli BW25113 assessed as compound concentration required for potentiation of novobiocin-induced antibacterial activity by 4 fold by checkerboard assay2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.
AID1445801Binding affinity to Escherichia coli AG100 His-tagged AcrA at 50 uM by SPR assay2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.
AID658163Stabilization of DNA duplex hairpin structure assessed as change in melting temperature at 1 uM by FRET assay2012Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries.
AID1445787Antimicrobial activity against Escherichia coli harboring AcrAB-TolC deletion mutant after 24 hrs by two-fold broth microdilution assay2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.
AID1445795Ratio of MIC for wild type Escherichia coli harboring 2.4 nM pores in the outer membrane to MIC for AcrAB-TolC knocked out Escherichia coli GD102 harboring 2.4 nM pores in the outer membrane2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.
AID1445788Antimicrobial activity against AcrAB-TolC knocked out Escherichia coli GD102 harboring 2.4 nM pores in the outer membrane after 24 hrs by two-fold broth microdilution assay2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.
AID1445794Ratio of MIC for wild type Escherichia coli BW25113 to MIC for Escherichia coli harboring 2.4 nM pores in the outer membrane2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.
AID1445786Antimicrobial activity against Escherichia coli harboring pores in outer membrane after 24 hrs by two-fold broth microdilution assay2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.
AID1445791Inhibition of AcrA in Escherichia coli assessed as increase in HT dye uptake at 25 uM measured up to 600 secs by fluorescence method2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.
AID1445790Binding affinity to Escherichia coli AG100 His-tagged AcrA at 25 uM by SPR assay2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.
AID1445796Ratio of MIC for wild type Escherichia coli harboring 2.4 nM pores in the outer membrane to MIC for wild type Escherichia coli harboring 2.4 nM pores in the outer membrane in presence of erythromycin2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.
AID1445798Ratio of MIC for wild type Escherichia coli harboring 2.4 nM pores in the outer membrane to MIC for wild type Escherichia coli harboring 2.4 nM pores in the outer membrane in presence of novobiocin2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.
AID658162Stabilization of human G-quadruplex F21T assessed as change in melting temperature at 1 uM by FRET assay2012Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries.
AID1445792Disruption of transmembrane potential in Escherichia coli live cells harboring pores in outer membrane at 10 uM by DiSC3(5) probe-based fluorescence assay2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.
AID1445797Inhibition of AcrA in Escherichia coli assessed as HT dye uptake at 25 uM measured up to 600 secs by fluorescence method relative to control2017Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14
Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.
AID1799481Competition Assay from Article 10.1016/S1074-5521(02)00281-8: \\Neoglycopeptides as inhibitors of oligosaccharyl transferase: insight into negotiating product inhibition.\\2002Chemistry & biology, Dec, Volume: 9, Issue:12
Neoglycopeptides as inhibitors of oligosaccharyl transferase: insight into negotiating product inhibition.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's5 (62.50)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
tolonium chloride
Tolonium Chloride: A phenothiazine that has been used as a hemostatic, a biological stain, and a dye for wool and silk. Tolonium chloride has also been used as a diagnostic aid for oral and gastric neoplasms and in the identification of the parathyroid gland in thyroid surgery.. tolonium chloride : An organic chloride salt having 3-amino-7-(dimethylamino)-2-methylphenothiazin-5-ium (tolonium) as the counterion. It is a blue nuclear counterstain that can be used to demonstrate Nissl substance and is also useful for staining mast cell granules, both in metachromatic and orthochromatic techniques.		2.0710
dequalinium chloride
dequalinium chloride : An organic chloride salt that is the dichloride salt of dequalinium.		2.0710organic chloride saltantifungal agent;
antineoplastic agent;
antiseptic drug;
mitochondrial NADH:ubiquinone reductase inhibitor
Berberine chloride (TN)
[no description available]		2.0710organic molecular entity
acodazole
[no description available]		2.0710
taspine
taspine: RN given refers to parent cpd; structure		2.0710
nsc 314622
NSC 314622: structure in first source		2.0710
dactinomycin
Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)		2.0110actinomycinmutagen
valinomycin
Valinomycin: A cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately to form a 36-membered ring. (From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies.. valinomycin : A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in several Streptomyces strains.		2.1510cyclodepsipeptide;
macrocycle		antimicrobial agent;
antiviral agent;
bacterial metabolite;
potassium ionophore
braco-19
BRACO-19: structure in first source		2.0710acridines;
N-alkylpyrrolidine
nk 5
NK 5: antioxidant containing divalent cations of iron, manganese, & cobalt		2.0710organic iodide salt;
quinolines		fluorochrome
lomofungin
lomofungin: antibiotic obtained from Streptomyces species; reported effective against bacteria as well as fungi & yeasts; probably inhibits nucleic acid & protein synthesis; minor descriptor (76-85); on-line & Index Medicus search PHENAZINES (76-85)		2.0110
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.0510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0510