Page last updated: 2024-12-08

phenoxodiol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

phenoxodiol: a synthetic derivative of DAIDZEIN [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID219100
CHEMBL ID1957038
SCHEMBL ID149612
MeSH IDM0445801

Synonyms (55)

Synonym
unii-995ft1w541
995ft1w541 ,
idronoxil [usan:inn]
81267-65-4
D04498
idronoxil (usan/inn)
dehydroequol
nv 06
2h-1-benzopyran-7-ol, 3-(4-hydroxyphenyl)-
phenoxodiol
3-(4-hydroxyphenyl)-2h-1-benzopyran-7-ol
idronoxil
haginin e
ccris 8949
3-(4-hydroxyphenyl)-2h-chromen-7-ol
7-hydroxy-3-hydroxyphenyl-1h-benzopyran
haganin e
nv-06
isoflav-3-ene4',7-diol
ZZUBHVMHNVYXRR-UHFFFAOYSA-N
3-(4-hydroxy-phenyl)-2h-chromen-7-ol
isoflav-3-ene-4',7-diol
4',7-dihydroxyisoflav-3-ene
AKOS015918005
S9634
bdbm50419932
CHEMBL1957038
FT-0602222
NCGC00346822-01
nox-66 component idronoxil
idronoxil [usan]
dehydroequol [mi]
idronoxil component of nox66 suppository
idronoxil [inn]
(+/-)-cis-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-3,4-dihydro-2h-cromen-7-ol
idronoxil [who-dd]
nox66 suppository component idronoxil
DB04915
smr004701684
MLS006010720
SCHEMBL149612
DTXSID50231029
7,4'-dihydroxyisoflav-3-ene
phenoxodiol, >=98% (hplc)
Q27095562
HY-13721
idronoxil;dehydroequol;haginin e
CS-0007751
NCGC00346822-02
MS-23403
phenoxodiol (haginin e)
A853212
XD161580
...7,4?-dihydroxyisoflav-3-ene
XD161694

Research Excerpts

Overview

Phenoxodiol (PXD) is a synthetic analogue of the plant isoflavone genistein with improved anticancer efficacy. It is 5-20 times more potent than genisten and has broad in vitro activity against a number of human cancer cell lines.

ExcerptReferenceRelevance
"Phenoxodiol is an isoflavene with potent anti-tumor activity. "( Synthesis of isoflavene-thiosemicarbazone hybrids and evaluation of their anti-tumor activity.
Black, DS; Brandl, MB; Kumar, N; Vittorio, O; Yee, EMH, 2017
)
1.9
"Phenoxodiol is an isoflavone analogue that possesses potent anticancer properties. "( Preparation, characterization and in vitro biological evaluation of (1:2) phenoxodiol-β-cyclodextrin complex.
Bhadbhade, MM; Black, DS; Brandl, MB; Hook, JM; Kuchel, RP; Kumar, N; Tilley, RD; Vittorio, O; Yee, EM, 2017
)
2.13
"Phenoxodiol is an isoflavone analog with antitumor activity against a variety of cancers."( Phenoxodiol enhances the antitumor activity of gemcitabine in gallbladder cancer through suppressing Akt/mTOR pathway.
Feng, J; Huang, X; Huang, Z; Li, Y, 2014
)
2.57
"Phenoxodiol is an experimental anticancer drug under development as a chemosensitizer intended to reverse multidrug resistance mechanisms in ovarian and prostate cancer cells to most standard cytotoxics. "( Phenoxodiol treatment alters the subsequent response of ENOX2 (tNOX) and growth of hela cells to paclitaxel and cisplatin.
Kelly, G; McClain, N; Morré, DJ; Morré, DM; Wu, LY, 2009
)
3.24
"Phenoxodiol is a novel isoflav-3-ene, currently undergoing clinical trials, that has a broad in vitro activity against a number of human cancer cell lines. "( Enhancement of the activity of phenoxodiol by cisplatin in prostate cancer cells.
de Souza, PL; Galettis, PT; McPherson, RA, 2009
)
2.08
"Phenoxodiol (PXD) is a synthetic analogue of the plant isoflavone genistein with improved anticancer efficacy. "( Phenoxodiol, an anticancer isoflavene, induces immunomodulatory effects in vitro and in vivo.
Bamias, A; Constantinou, AI; Dimopoulos, MA; Georgaki, S; Husband, A; Ioannou, K; Nicolaou, KA; Skopeliti, M; Tsiatas, M; Tsitsilonis, OE, 2009
)
3.24
"Phenoxodiol is a derivative of the isoflavone genisten that is 5-20 times more potent than genisten."( Flavonoids, phenoxodiol, and a novel agent, triphendiol, for the treatment of pancreaticobiliary cancers.
Brown, DM; Husband, AJ; Lansigan, F; Saif, MW; Tytler, E, 2009
)
1.45
"Phenoxodiol is a synthetic derivative of the naturally occurring plant isoflavone genistein. "( Phenoxodiol: pharmacology and clinical experience in cancer monotherapy and in combination with chemotherapeutic drugs.
Alvero, AB; Brown, D; Mor, G; Rutherford, TJ; Silasi, DA, 2009
)
3.24
"Phenoxodiol is a novel isoflavone currently being studied in clinical trials for the treatment of cancer. "( Pharmacokinetics of phenoxodiol, a novel isoflavone, following intravenous administration to patients with advanced cancer.
de Souza, PL; Howes, JB; Howes, LG; Huang, LJ; West, L, 2011
)
2.14
"Phenoxodiol is a novel biomodulator capable of reversing chemoresistance in vitro and in vivo."( Phase II evaluation of phenoxodiol in combination with cisplatin or paclitaxel in women with platinum/taxane-refractory/resistant epithelial ovarian, fallopian tube, or primary peritoneal cancers.
Azodi, M; Baker, L; Husband, A; Kelly, MG; Mor, G; O'Malley, DM; Rutherford, TJ; Schwartz, PE, 2011
)
1.4
"Phenoxodiol is an isoflavone derivative that has been shown to elicit cytotoxic effects against a broad range of human cancers. "( Cytotoxic effects of the novel isoflavone, phenoxodiol, on prostate cancer cell lines.
Arfuso, F; Brown, D; Dharmarajan, A; Hisheh, S; Mahoney, S; Millward, M; Rogers, P, 2012
)
2.08
"Phenoxodiol is a synthetic derivative of the plant isoflavone daidzein and is currently undergoing clinical testing as a cancer therapeutic drug."( Phenoxodiol (2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl)), a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complex.
Constantinou, AI; Husband, A,
)
2.3
"Phenoxodiol is a multi-pathway initiator of apoptosis with broad anti-tumor activity and high specificity for tumor cells. "( Phase I trial of phenoxodiol delivered by continuous intravenous infusion in patients with solid cancer.
Bukowski, RM; Choueiri, TK; Ganapathi, R; Hutson, TE; Kelly, GE; Mekhail, T, 2006
)
2.12
"Phenoxodiol is a chemically modified analogue of the plant hormone isoflavone with antitumour activities. "( Involvement of BH3-only proapoptotic proteins in mitochondrial-dependent Phenoxodiol-induced apoptosis of human melanoma cells.
Borrow, JM; Hersey, P; Watts, RN; Yu, F; Zhang, XD, 2006
)
2.01
"Phenoxodiol is a new chemotherapeutic agent that has anti-proliferative and apoptotic effects on a range of cancer cells."( Phenoxodiol protects against Cisplatin induced neurite toxicity in a PC-12 cell model.
Brown, D; Klein, R; Turnley, AM, 2007
)
2.5

Effects

ExcerptReferenceRelevance
"Phenoxodiol has a short plasma half-life, particularly in the free form, leading to a rapid attainment of steady state levels during continuous intravenous infusion."( Pharmacokinetics of phenoxodiol, a novel isoflavone, following intravenous administration to patients with advanced cancer.
de Souza, PL; Howes, JB; Howes, LG; Huang, LJ; West, L, 2011
)
2.14
"Phenoxodiol has a short plasma half-life, particularly in the free form, leading to a rapid attainment of steady state levels during continuous intravenous infusion."( Pharmacokinetics of phenoxodiol, a novel isoflavone, following intravenous administration to patients with advanced cancer.
de Souza, PL; Howes, JB; Howes, LG; Huang, LJ; West, L, 2011
)
2.14

Actions

ExcerptReferenceRelevance
"Phenoxodiol did not inhibit topo I catalytic activity nor did it stabilize the topo I-mediated cleavable complex."( Phenoxodiol (2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl)), a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complex.
Constantinou, AI; Husband, A,
)
2.3

Treatment

Phenoxodiol treatment promoted a marked inhibition of proliferation and loss of colony formation in LNCaP cells. Treatment increased the number of annexin-V-positive cells as well as the expression of cleaved poly ADP ribose polymerase.

ExcerptReferenceRelevance
"Phenoxodiol treatment promoted a marked inhibition of proliferation and loss of colony formation in LNCaP cells in a dose- and time-dependent manner. "( Phenoxodiol inhibits growth of metastatic prostate cancer cells.
Aguero, MF; Brown, DM; Espinoza, LA; Smulson, ME; Venero, M, 2010
)
3.25
"Treatment with phenoxodiol increased the number of annexin-V-positive cells as well as the expression of cleaved poly ADP ribose polymerase, demonstrating that phenoxodiol induced apoptosis in renal cancer cells."( Evaluation of Therapeutic Potential of Phenoxodiol, a Novel Isoflavone Analog, in Renal Cancer Cells.
Asano, T; Isono, M; Okubo, K; Sato, A, 2018
)
1.09
"Pre-treating Phenoxodiol sensitive cells with Phenoxodiol prior to Carboplatin resulted in XIAP degradation, associated with Carboplatin sensitization and apoptosis, whereas exposing Phenoxodiol resistant cells to Phenoxodiol resulted in less XIAP degradation and minimal Carboplatin sensitization."( The X-linked inhibitor of apoptosis protein (XIAP) is up-regulated in metastatic melanoma, and XIAP cleavage by Phenoxodiol is associated with Carboplatin sensitization.
Alvero, AB; Ariyan, S; Camp, RL; Kluger, HM; McCarthy, MM; Mor, G; Rimm, DL; Sznol, M, 2007
)
0.9

Pharmacokinetics

ExcerptReferenceRelevance
" Plasma sampling was undertaken to characterize the pharmacokinetic (PK) profile of the compound."( Phase I and pharmacokinetic study of weekly NV06 (Phenoxodiol), a novel isoflav-3-ene, in patients with advanced cancer.
de Souza, PL; Howes, LG; Kelly, G; Liauw, W; Links, M; Pirabhahar, S, 2006
)
0.59
" The plasma half-life (T1/2), clearance (Cl), and volume of distribution (VD) were 304 (+/-91) min, 82 (+/-19) ml/min and 32,663 (+/-7,199) ml, respectively, for total NV06."( Phase I and pharmacokinetic study of weekly NV06 (Phenoxodiol), a novel isoflav-3-ene, in patients with advanced cancer.
de Souza, PL; Howes, LG; Kelly, G; Liauw, W; Links, M; Pirabhahar, S, 2006
)
0.59

Compound-Compound Interactions

ExcerptReferenceRelevance
" In this study, we determined the safety and efficacy of intravenous phenoxodiol in combination with cisplatin or paclitaxel in women with platinum/taxane-refractory/resistant ovarian cancers."( Phase II evaluation of phenoxodiol in combination with cisplatin or paclitaxel in women with platinum/taxane-refractory/resistant epithelial ovarian, fallopian tube, or primary peritoneal cancers.
Azodi, M; Baker, L; Husband, A; Kelly, MG; Mor, G; O'Malley, DM; Rutherford, TJ; Schwartz, PE, 2011
)
0.91

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
" Whilst clinically tested in the past, idronoxil's journey was discontinued as a result of its low bioavailability in humans when administered either intravenously or orally, though strategies to overcome this issue are currently being explored."( Idronoxil as an Anticancer Agent: Activity and Mechanisms.
Delebecque, F; Fairlie, WD; Laczka, O; Porter, K; Wilkinson, J, 2020
)
0.56

Dosage Studied

This phase I, single-center trial was conducted to test a continuous intravenous dosing regimen of phenoxodiol in patients with late-stage, solid tumors. Pharmacokinetics suggested a linear relationship between dosage and mean steady-state plasma concentrations.

ExcerptRelevanceReference
" This phase I, single-center trial was conducted to test a continuous intravenous dosing regimen of phenoxodiol in patients with late-stage, solid tumors to determine toxicity, pharmacokinetics, and preliminary efficacy."( Phase I trial of phenoxodiol delivered by continuous intravenous infusion in patients with solid cancer.
Bukowski, RM; Choueiri, TK; Ganapathi, R; Hutson, TE; Kelly, GE; Mekhail, T, 2006
)
0.89
" Pharmacokinetics suggested a linear relationship between dosage and mean steady-state plasma concentrations of phenoxodiol."( Phase I trial of phenoxodiol delivered by continuous intravenous infusion in patients with solid cancer.
Bukowski, RM; Choueiri, TK; Ganapathi, R; Hutson, TE; Kelly, GE; Mekhail, T, 2006
)
0.88
"Responses were evaluated from dose-response curves of the metabolites and metabolic inhibitors in which growth of HeLa cells, apoptosis based on DAPI fluorescence and cytosolic NADH levels were correlated with sphingomyelinase and spingosine kinase activities and levels of ceramide and sphingosine1-phosphate."( Metabolite modulation of HeLa cell response to ENOX2 inhibitors EGCG and phenoxodiol.
De Luca, T; Morré, DJ; Morré, DM; Watanabe, T; Wu, LY, 2011
)
0.6
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (6)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Fumarate hydrataseHomo sapiens (human)Potency10.49040.00308.794948.0869AID1347053
PPM1D proteinHomo sapiens (human)Potency11.70860.00529.466132.9993AID1347411
EWS/FLI fusion proteinHomo sapiens (human)Potency4.71880.001310.157742.8575AID1259252; AID1259253; AID1259255; AID1259256
polyproteinZika virusPotency10.49040.00308.794948.0869AID1347053
Interferon betaHomo sapiens (human)Potency11.70860.00339.158239.8107AID1347411
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Estrogen receptorRattus norvegicus (Norway rat)IC50 (µMol)0.66070.00074.152114.1600AID650636
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (30)

Processvia Protein(s)Taxonomy
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell activation involved in immune responseInterferon betaHomo sapiens (human)
cell surface receptor signaling pathwayInterferon betaHomo sapiens (human)
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to virusInterferon betaHomo sapiens (human)
positive regulation of autophagyInterferon betaHomo sapiens (human)
cytokine-mediated signaling pathwayInterferon betaHomo sapiens (human)
natural killer cell activationInterferon betaHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylation of STAT proteinInterferon betaHomo sapiens (human)
cellular response to interferon-betaInterferon betaHomo sapiens (human)
B cell proliferationInterferon betaHomo sapiens (human)
negative regulation of viral genome replicationInterferon betaHomo sapiens (human)
innate immune responseInterferon betaHomo sapiens (human)
positive regulation of innate immune responseInterferon betaHomo sapiens (human)
regulation of MHC class I biosynthetic processInterferon betaHomo sapiens (human)
negative regulation of T cell differentiationInterferon betaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIInterferon betaHomo sapiens (human)
defense response to virusInterferon betaHomo sapiens (human)
type I interferon-mediated signaling pathwayInterferon betaHomo sapiens (human)
neuron cellular homeostasisInterferon betaHomo sapiens (human)
cellular response to exogenous dsRNAInterferon betaHomo sapiens (human)
cellular response to virusInterferon betaHomo sapiens (human)
negative regulation of Lewy body formationInterferon betaHomo sapiens (human)
negative regulation of T-helper 2 cell cytokine productionInterferon betaHomo sapiens (human)
positive regulation of apoptotic signaling pathwayInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell differentiationInterferon betaHomo sapiens (human)
natural killer cell activation involved in immune responseInterferon betaHomo sapiens (human)
adaptive immune responseInterferon betaHomo sapiens (human)
T cell activation involved in immune responseInterferon betaHomo sapiens (human)
humoral immune responseInterferon betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
cytokine activityInterferon betaHomo sapiens (human)
cytokine receptor bindingInterferon betaHomo sapiens (human)
type I interferon receptor bindingInterferon betaHomo sapiens (human)
protein bindingInterferon betaHomo sapiens (human)
chloramphenicol O-acetyltransferase activityInterferon betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (2)

Processvia Protein(s)Taxonomy
extracellular spaceInterferon betaHomo sapiens (human)
extracellular regionInterferon betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (54)

Assay IDTitleYearJournalArticle
AID737840Antiproliferative activity against human SHEP cells by measuring metabolic activity of cells after 72 hrs by spectrophotometric analysis2013Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents.
AID1474778Growth inhibition of human SK-N-BE(2) cells after 72 hrs by Alamar blue assay2017Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
Synthesis of isoflavene-thiosemicarbazone hybrids and evaluation of their anti-tumor activity.
AID650641Vasorelaxant activity in Sprague-Dawley rat thoracic aorta assessed as inhibition of phenylephirne-induced contraction2012Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition.
AID1474777Selectivity ratio of IC50 for human MRC5 cells to GI50 for human MDA-MB-231 cells2017Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
Synthesis of isoflavene-thiosemicarbazone hybrids and evaluation of their anti-tumor activity.
AID650636Displacement of [3H]estradiol from rat uterine cytosolic estrogen receptor2012Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition.
AID1162585Antiproliferative activity against human SHEP cells after 72 hrs by Alamar blue/spectrophotometric analysis2014Bioorganic & medicinal chemistry, Oct-01, Volume: 22, Issue:19
Synthesis, anti-cancer and anti-inflammatory activity of novel 2-substituted isoflavenes.
AID1474782Selectivity ratio of IC50 for human MRC5 cells to GI50 for human U87 cells2017Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
Synthesis of isoflavene-thiosemicarbazone hybrids and evaluation of their anti-tumor activity.
AID1474781Cytotoxicity against human MRC5 cells after 72 hrs by Alamar blue assay2017Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
Synthesis of isoflavene-thiosemicarbazone hybrids and evaluation of their anti-tumor activity.
AID737833Antiangiogenic activity in human HMEC1 cells at 5 uM after 8 hrs by matrigel assay2013Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents.
AID737841Antiproliferative activity against human MDA-MB-231 cells by measuring metabolic activity of cells after 72 hrs by spectrophotometric analysis2013Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents.
AID1474776Selectivity ratio of IC50 for human MRC5 cells to GI50 for human SK-N-BE(2) cells2017Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
Synthesis of isoflavene-thiosemicarbazone hybrids and evaluation of their anti-tumor activity.
AID1162586Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by Alamar blue/spectrophotometric analysis2014Bioorganic & medicinal chemistry, Oct-01, Volume: 22, Issue:19
Synthesis, anti-cancer and anti-inflammatory activity of novel 2-substituted isoflavenes.
AID737834Antiangiogenic activity in human HMEC1 cells at 1 uM after 8 hrs by matrigel assay2013Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents.
AID1474780Growth inhibition of human U87 cells after 72 hrs by Alamar blue assay2017Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
Synthesis of isoflavene-thiosemicarbazone hybrids and evaluation of their anti-tumor activity.
AID737836Selectivity ratio of GI50 for human MRC5 cells to GI50 for human MDA-MB-231 cells2013Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents.
AID1474779Growth inhibition of human MDA-MB-231 cells after 72 hrs by Alamar blue assay2017Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
Synthesis of isoflavene-thiosemicarbazone hybrids and evaluation of their anti-tumor activity.
AID737837Selectivity ratio of GI50 for human MRC5 cells to GI50 for human SHEP cells2013Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents.
AID737842Antiproliferative activity against human HMEC1 cells by measuring metabolic activity of cells after 72 hrs by spectrophotometric analysis2013Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents.
AID737835Antiangiogenic activity in human HMEC1 cells at 10 uM after 8 hrs by matrigel assay2013Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents.
AID650640Vasorelaxant activity in Sprague-Dawley rat thoracic aorta assessed as inhibition of phenylephirne-induced contraction in presence of 0.1 uM estrogen receptor antagonist ICI 1827802012Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition.
AID737839Antiproliferative activity against human MRC5 cells by measuring metabolic activity of cells after 72 hrs by spectrophotometric analysis2013Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents.
AID650639Vasorelaxant activity in Sprague-Dawley rat thoracic aorta assessed as inhibition of U46619-induced vascular tension at 100 uM pretreated for 30 mins2012Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition.
AID650637Vasorelaxant activity in Sprague-Dawley rat thoracic aorta assessed as inhibition of U46619-induced GTP RhoA level at 100 uM pretreated for 30 mins measured after 45 mins by spectrometric analysis2012Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition.
AID737838Selectivity ratio of GI50 for human MRC5 cells to GI50 for human HMEC1 cells2013Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents.
AID1347106qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID1347102qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347090qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347091qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347107qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347097qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347092qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347099qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347100qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347108qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347103qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347089qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347101qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347096qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347095qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347105qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347098qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347094qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347093qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347104qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347411qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (64)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's34 (53.13)29.6817
2010's21 (32.81)24.3611
2020's9 (14.06)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.80 (24.57)
Research Supply Index4.30 (2.92)
Research Growth Index4.46 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.80)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials6 (8.96%)5.53%
Reviews9 (13.43%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other52 (77.61%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]