phenoxodiol: a synthetic derivative of DAIDZEIN [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 219100 |
CHEMBL ID | 1957038 |
SCHEMBL ID | 149612 |
MeSH ID | M0445801 |
Synonym |
---|
unii-995ft1w541 |
995ft1w541 , |
idronoxil [usan:inn] |
81267-65-4 |
D04498 |
idronoxil (usan/inn) |
dehydroequol |
nv 06 |
2h-1-benzopyran-7-ol, 3-(4-hydroxyphenyl)- |
phenoxodiol |
3-(4-hydroxyphenyl)-2h-1-benzopyran-7-ol |
idronoxil |
haginin e |
ccris 8949 |
3-(4-hydroxyphenyl)-2h-chromen-7-ol |
7-hydroxy-3-hydroxyphenyl-1h-benzopyran |
haganin e |
nv-06 |
isoflav-3-ene4',7-diol |
ZZUBHVMHNVYXRR-UHFFFAOYSA-N |
3-(4-hydroxy-phenyl)-2h-chromen-7-ol |
isoflav-3-ene-4',7-diol |
4',7-dihydroxyisoflav-3-ene |
AKOS015918005 |
S9634 |
bdbm50419932 |
CHEMBL1957038 |
FT-0602222 |
NCGC00346822-01 |
nox-66 component idronoxil |
idronoxil [usan] |
dehydroequol [mi] |
idronoxil component of nox66 suppository |
idronoxil [inn] |
(+/-)-cis-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-3,4-dihydro-2h-cromen-7-ol |
idronoxil [who-dd] |
nox66 suppository component idronoxil |
DB04915 |
smr004701684 |
MLS006010720 |
SCHEMBL149612 |
DTXSID50231029 |
7,4'-dihydroxyisoflav-3-ene |
phenoxodiol, >=98% (hplc) |
Q27095562 |
HY-13721 |
idronoxil;dehydroequol;haginin e |
CS-0007751 |
NCGC00346822-02 |
MS-23403 |
phenoxodiol (haginin e) |
A853212 |
XD161580 |
...7,4?-dihydroxyisoflav-3-ene |
XD161694 |
Phenoxodiol (PXD) is a synthetic analogue of the plant isoflavone genistein with improved anticancer efficacy. It is 5-20 times more potent than genisten and has broad in vitro activity against a number of human cancer cell lines.
Excerpt | Reference | Relevance |
---|---|---|
"Phenoxodiol has a short plasma half-life, particularly in the free form, leading to a rapid attainment of steady state levels during continuous intravenous infusion." | ( Pharmacokinetics of phenoxodiol, a novel isoflavone, following intravenous administration to patients with advanced cancer. de Souza, PL; Howes, JB; Howes, LG; Huang, LJ; West, L, 2011) | 2.14 |
"Phenoxodiol has a short plasma half-life, particularly in the free form, leading to a rapid attainment of steady state levels during continuous intravenous infusion." | ( Pharmacokinetics of phenoxodiol, a novel isoflavone, following intravenous administration to patients with advanced cancer. de Souza, PL; Howes, JB; Howes, LG; Huang, LJ; West, L, 2011) | 2.14 |
Excerpt | Reference | Relevance |
---|---|---|
"Phenoxodiol did not inhibit topo I catalytic activity nor did it stabilize the topo I-mediated cleavable complex." | ( Phenoxodiol (2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl)), a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complex. Constantinou, AI; Husband, A, ) | 2.3 |
Phenoxodiol treatment promoted a marked inhibition of proliferation and loss of colony formation in LNCaP cells. Treatment increased the number of annexin-V-positive cells as well as the expression of cleaved poly ADP ribose polymerase.
Excerpt | Reference | Relevance |
---|---|---|
"Phenoxodiol treatment promoted a marked inhibition of proliferation and loss of colony formation in LNCaP cells in a dose- and time-dependent manner. " | ( Phenoxodiol inhibits growth of metastatic prostate cancer cells. Aguero, MF; Brown, DM; Espinoza, LA; Smulson, ME; Venero, M, 2010) | 3.25 |
"Treatment with phenoxodiol increased the number of annexin-V-positive cells as well as the expression of cleaved poly ADP ribose polymerase, demonstrating that phenoxodiol induced apoptosis in renal cancer cells." | ( Evaluation of Therapeutic Potential of Phenoxodiol, a Novel Isoflavone Analog, in Renal Cancer Cells. Asano, T; Isono, M; Okubo, K; Sato, A, 2018) | 1.09 |
"Pre-treating Phenoxodiol sensitive cells with Phenoxodiol prior to Carboplatin resulted in XIAP degradation, associated with Carboplatin sensitization and apoptosis, whereas exposing Phenoxodiol resistant cells to Phenoxodiol resulted in less XIAP degradation and minimal Carboplatin sensitization." | ( The X-linked inhibitor of apoptosis protein (XIAP) is up-regulated in metastatic melanoma, and XIAP cleavage by Phenoxodiol is associated with Carboplatin sensitization. Alvero, AB; Ariyan, S; Camp, RL; Kluger, HM; McCarthy, MM; Mor, G; Rimm, DL; Sznol, M, 2007) | 0.9 |
Excerpt | Reference | Relevance |
---|---|---|
" Plasma sampling was undertaken to characterize the pharmacokinetic (PK) profile of the compound." | ( Phase I and pharmacokinetic study of weekly NV06 (Phenoxodiol), a novel isoflav-3-ene, in patients with advanced cancer. de Souza, PL; Howes, LG; Kelly, G; Liauw, W; Links, M; Pirabhahar, S, 2006) | 0.59 |
" The plasma half-life (T1/2), clearance (Cl), and volume of distribution (VD) were 304 (+/-91) min, 82 (+/-19) ml/min and 32,663 (+/-7,199) ml, respectively, for total NV06." | ( Phase I and pharmacokinetic study of weekly NV06 (Phenoxodiol), a novel isoflav-3-ene, in patients with advanced cancer. de Souza, PL; Howes, LG; Kelly, G; Liauw, W; Links, M; Pirabhahar, S, 2006) | 0.59 |
Excerpt | Reference | Relevance |
---|---|---|
" In this study, we determined the safety and efficacy of intravenous phenoxodiol in combination with cisplatin or paclitaxel in women with platinum/taxane-refractory/resistant ovarian cancers." | ( Phase II evaluation of phenoxodiol in combination with cisplatin or paclitaxel in women with platinum/taxane-refractory/resistant epithelial ovarian, fallopian tube, or primary peritoneal cancers. Azodi, M; Baker, L; Husband, A; Kelly, MG; Mor, G; O'Malley, DM; Rutherford, TJ; Schwartz, PE, 2011) | 0.91 |
Excerpt | Reference | Relevance |
---|---|---|
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
" Whilst clinically tested in the past, idronoxil's journey was discontinued as a result of its low bioavailability in humans when administered either intravenously or orally, though strategies to overcome this issue are currently being explored." | ( Idronoxil as an Anticancer Agent: Activity and Mechanisms. Delebecque, F; Fairlie, WD; Laczka, O; Porter, K; Wilkinson, J, 2020) | 0.56 |
This phase I, single-center trial was conducted to test a continuous intravenous dosing regimen of phenoxodiol in patients with late-stage, solid tumors. Pharmacokinetics suggested a linear relationship between dosage and mean steady-state plasma concentrations.
Excerpt | Relevance | Reference |
---|---|---|
" This phase I, single-center trial was conducted to test a continuous intravenous dosing regimen of phenoxodiol in patients with late-stage, solid tumors to determine toxicity, pharmacokinetics, and preliminary efficacy." | ( Phase I trial of phenoxodiol delivered by continuous intravenous infusion in patients with solid cancer. Bukowski, RM; Choueiri, TK; Ganapathi, R; Hutson, TE; Kelly, GE; Mekhail, T, 2006) | 0.89 |
" Pharmacokinetics suggested a linear relationship between dosage and mean steady-state plasma concentrations of phenoxodiol." | ( Phase I trial of phenoxodiol delivered by continuous intravenous infusion in patients with solid cancer. Bukowski, RM; Choueiri, TK; Ganapathi, R; Hutson, TE; Kelly, GE; Mekhail, T, 2006) | 0.88 |
"Responses were evaluated from dose-response curves of the metabolites and metabolic inhibitors in which growth of HeLa cells, apoptosis based on DAPI fluorescence and cytosolic NADH levels were correlated with sphingomyelinase and spingosine kinase activities and levels of ceramide and sphingosine1-phosphate." | ( Metabolite modulation of HeLa cell response to ENOX2 inhibitors EGCG and phenoxodiol. De Luca, T; Morré, DJ; Morré, DM; Watanabe, T; Wu, LY, 2011) | 0.6 |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Fumarate hydratase | Homo sapiens (human) | Potency | 10.4904 | 0.0030 | 8.7949 | 48.0869 | AID1347053 |
PPM1D protein | Homo sapiens (human) | Potency | 11.7086 | 0.0052 | 9.4661 | 32.9993 | AID1347411 |
EWS/FLI fusion protein | Homo sapiens (human) | Potency | 4.7188 | 0.0013 | 10.1577 | 42.8575 | AID1259252; AID1259253; AID1259255; AID1259256 |
polyprotein | Zika virus | Potency | 10.4904 | 0.0030 | 8.7949 | 48.0869 | AID1347053 |
Interferon beta | Homo sapiens (human) | Potency | 11.7086 | 0.0033 | 9.1582 | 39.8107 | AID1347411 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Estrogen receptor | Rattus norvegicus (Norway rat) | IC50 (µMol) | 0.6607 | 0.0007 | 4.1521 | 14.1600 | AID650636 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Process | via Protein(s) | Taxonomy |
---|---|---|
cytokine activity | Interferon beta | Homo sapiens (human) |
cytokine receptor binding | Interferon beta | Homo sapiens (human) |
type I interferon receptor binding | Interferon beta | Homo sapiens (human) |
protein binding | Interferon beta | Homo sapiens (human) |
chloramphenicol O-acetyltransferase activity | Interferon beta | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Process | via Protein(s) | Taxonomy |
---|---|---|
extracellular space | Interferon beta | Homo sapiens (human) |
extracellular region | Interferon beta | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID737840 | Antiproliferative activity against human SHEP cells by measuring metabolic activity of cells after 72 hrs by spectrophotometric analysis | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7 | Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents. |
AID1474778 | Growth inhibition of human SK-N-BE(2) cells after 72 hrs by Alamar blue assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | Synthesis of isoflavene-thiosemicarbazone hybrids and evaluation of their anti-tumor activity. |
AID650641 | Vasorelaxant activity in Sprague-Dawley rat thoracic aorta assessed as inhibition of phenylephirne-induced contraction | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7 | 2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition. |
AID1474777 | Selectivity ratio of IC50 for human MRC5 cells to GI50 for human MDA-MB-231 cells | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | Synthesis of isoflavene-thiosemicarbazone hybrids and evaluation of their anti-tumor activity. |
AID650636 | Displacement of [3H]estradiol from rat uterine cytosolic estrogen receptor | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7 | 2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition. |
AID1162585 | Antiproliferative activity against human SHEP cells after 72 hrs by Alamar blue/spectrophotometric analysis | 2014 | Bioorganic & medicinal chemistry, Oct-01, Volume: 22, Issue:19 | Synthesis, anti-cancer and anti-inflammatory activity of novel 2-substituted isoflavenes. |
AID1474782 | Selectivity ratio of IC50 for human MRC5 cells to GI50 for human U87 cells | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | Synthesis of isoflavene-thiosemicarbazone hybrids and evaluation of their anti-tumor activity. |
AID1474781 | Cytotoxicity against human MRC5 cells after 72 hrs by Alamar blue assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | Synthesis of isoflavene-thiosemicarbazone hybrids and evaluation of their anti-tumor activity. |
AID737833 | Antiangiogenic activity in human HMEC1 cells at 5 uM after 8 hrs by matrigel assay | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7 | Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents. |
AID737841 | Antiproliferative activity against human MDA-MB-231 cells by measuring metabolic activity of cells after 72 hrs by spectrophotometric analysis | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7 | Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents. |
AID1474776 | Selectivity ratio of IC50 for human MRC5 cells to GI50 for human SK-N-BE(2) cells | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | Synthesis of isoflavene-thiosemicarbazone hybrids and evaluation of their anti-tumor activity. |
AID1162586 | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by Alamar blue/spectrophotometric analysis | 2014 | Bioorganic & medicinal chemistry, Oct-01, Volume: 22, Issue:19 | Synthesis, anti-cancer and anti-inflammatory activity of novel 2-substituted isoflavenes. |
AID737834 | Antiangiogenic activity in human HMEC1 cells at 1 uM after 8 hrs by matrigel assay | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7 | Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents. |
AID1474780 | Growth inhibition of human U87 cells after 72 hrs by Alamar blue assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | Synthesis of isoflavene-thiosemicarbazone hybrids and evaluation of their anti-tumor activity. |
AID737836 | Selectivity ratio of GI50 for human MRC5 cells to GI50 for human MDA-MB-231 cells | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7 | Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents. |
AID1474779 | Growth inhibition of human MDA-MB-231 cells after 72 hrs by Alamar blue assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11 | Synthesis of isoflavene-thiosemicarbazone hybrids and evaluation of their anti-tumor activity. |
AID737837 | Selectivity ratio of GI50 for human MRC5 cells to GI50 for human SHEP cells | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7 | Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents. |
AID737842 | Antiproliferative activity against human HMEC1 cells by measuring metabolic activity of cells after 72 hrs by spectrophotometric analysis | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7 | Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents. |
AID737835 | Antiangiogenic activity in human HMEC1 cells at 10 uM after 8 hrs by matrigel assay | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7 | Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents. |
AID650640 | Vasorelaxant activity in Sprague-Dawley rat thoracic aorta assessed as inhibition of phenylephirne-induced contraction in presence of 0.1 uM estrogen receptor antagonist ICI 182780 | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7 | 2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition. |
AID737839 | Antiproliferative activity against human MRC5 cells by measuring metabolic activity of cells after 72 hrs by spectrophotometric analysis | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7 | Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents. |
AID650639 | Vasorelaxant activity in Sprague-Dawley rat thoracic aorta assessed as inhibition of U46619-induced vascular tension at 100 uM pretreated for 30 mins | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7 | 2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition. |
AID650637 | Vasorelaxant activity in Sprague-Dawley rat thoracic aorta assessed as inhibition of U46619-induced GTP RhoA level at 100 uM pretreated for 30 mins measured after 45 mins by spectrometric analysis | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7 | 2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition. |
AID737838 | Selectivity ratio of GI50 for human MRC5 cells to GI50 for human HMEC1 cells | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7 | Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents. |
AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 34 (53.13) | 29.6817 |
2010's | 21 (32.81) | 24.3611 |
2020's | 9 (14.06) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (21.80) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 6 (8.96%) | 5.53% |
Reviews | 9 (13.43%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 52 (77.61%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |